Zobrazeno 1 - 10
of 349
pro vyhledávání: '"V. Kalia"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Accumulation of α-synuclein (α-Syn) has been implicated in proteasome and autophagy dysfunction in Parkinson’s disease (PD). High frequency electrical stimulation (HFS) mimicking clinical parameters used for deep brain stimulation (DBS)
Externí odkaz:
https://doaj.org/article/ee09962a47ad4a929326c95bfe763b4d
Autor:
Rebecca Earnshaw, Yu Tong Zhang, Gregory Heymann, Kazuko Fujisawa, Sarah Hui, Minesh Kapadia, Lorraine V. Kalia, Suneil K. Kalia
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106625- (2024)
C-terminus of HSP70 interacting protein (CHIP) is an E3 ubiquitin ligase and HSP70 cochaperone. Mutations in the CHIP encoding gene are the cause of two neurodegenerative conditions: spinocerebellar ataxia autosomal dominant type 48 (SCA48) and autos
Externí odkaz:
https://doaj.org/article/982a52532ce347349e5843e7fae51f8c
Autor:
Eun Jung Lee, David Hernán Aguirre-Padilla, Anton Fomenko, Grishma Pawar, Minesh Kapadia, Jimmy George, Andres M. Lozano, Clement Hamani, Lorraine V. Kalia, Suneil K. Kalia
Publikováno v:
Brain Stimulation, Vol 17, Iss 2, Pp 166-175 (2024)
Background: Deep brain stimulation (DBS) has been widely used to manage debilitating neurological symptoms in movement disorders such as Parkinson's disease (PD). Despite its well-established symptomatic benefits, our understanding of the mechanisms
Externí odkaz:
https://doaj.org/article/86e2f9f0b08a4b4987f2500b2e669775
Autor:
Satra Nim, Darren M. O’Hara, Carles Corbi-Verge, Albert Perez-Riba, Kazuko Fujisawa, Minesh Kapadia, Hien Chau, Federica Albanese, Grishma Pawar, Mitchell L. De Snoo, Sophie G. Ngana, Jisun Kim, Omar M. A. El-Agnaf, Enrico Rennella, Lewis E. Kay, Suneil K. Kalia, Lorraine V. Kalia, Philip M. Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a high-throughput, proteome-wide peptide screen to identify protein-protein interaction
Externí odkaz:
https://doaj.org/article/5d9353322078445d81d882610543e049
Autor:
Ying Meng, Lorraine V. Kalia, Suneil K. Kalia, Clement Hamani, Yuexi Huang, Kullervo Hynynen, Nir Lipsman, Benjamin Davidson
Publikováno v:
Pharmaceutics, Vol 16, Iss 6, p 719 (2024)
This review discusses the current progress in the clinical use of magnetic resonance-guided focused ultrasound (MRgFUS) and other ultrasound platforms to transiently permeabilize the blood-brain barrier (BBB) for drug delivery in neurological disorde
Externí odkaz:
https://doaj.org/article/8912977789b44ea4a1207fa3ce0029ee
Autor:
Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler, Naomi P. Visanji, Connie Marras, Nour K. Majbour, Omar M. A. El-Agnaf, Andres M. Lozano, Joseph Culotti, Satoshi Suo, William S. Ryu, Suneil K. Kalia, Lorraine V. Kalia
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-25 (2021)
Abstract Background Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Parkinson’s diseas
Externí odkaz:
https://doaj.org/article/1a816ab50aad45a9bf006d7c91b18cff
Akademický článek
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Autor:
Chris McKinnon, Mitchell L. De Snoo, Elise Gondard, Clemens Neudorfer, Hien Chau, Sophie G. Ngana, Darren M. O’Hara, Jonathan M. Brotchie, James B. Koprich, Andres M. Lozano, Lorraine V. Kalia, Suneil K. Kalia
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-16 (2020)
Abstract Parkinson’s disease is a progressive neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein in selected brain regions, including the substantia nigra pars compacta (SNpc), where marked loss of dopaminergic n
Externí odkaz:
https://doaj.org/article/7dfa04f473804946a578917f019e470a
Autor:
Yuexi Huang, Ying Meng, Christopher B. Pople, Allison Bethune, Ryan M. Jones, Agessandro Abrahao, Clement Hamani, Suneil K. Kalia, Lorraine V. Kalia, Nir Lipsman, Kullervo Hynynen
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2607 (2022)
Magnetic resonance-guided focused ultrasound (MRgFUS), in conjunction with circulating microbubbles, is an emerging technology that can transiently enhance the permeability of the blood-brain barrier (BBB) locally and non-invasively to facilitate tar
Externí odkaz:
https://doaj.org/article/c2c534cc2ecb4ce7ba8ddd5945c58e5e
Publikováno v:
Seminars in Neurology. 43:147-155
Genetics are fundamental to understanding the pathophysiology of neurological disease, including movement disorders. Genetic testing in clinical practice has changed dramatically over the last few decades. While the likelihood of establishing an etio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9d3979c86c159dc69baf99975249573
https://doi.org/10.1055/s-0043-1763507
https://doi.org/10.1055/s-0043-1763507