Zobrazeno 1 - 10 of 56 pro vyhledávání: '"V. K. Kuchroo"'
1
Akademický článek
Predictors of responses to immune checkpoint blockade in advanced melanoma
Autor: N. Jacquelot, M. P. Roberti, D. P. Enot, S. Rusakiewicz, N. Ternès, S. Jegou, D. M. Woods, A. L. Sodré, M. Hansen, Y. Meirow, M. Sade-Feldman, A. Burra, S. S. Kwek, C. Flament, M. Messaoudene, C. P. M. Duong, L. Chen, B. S. Kwon, A. C. Anderson, V. K. Kuchroo, B. Weide, F. Aubin, C. Borg, S. Dalle, O. Beatrix, M. Ayyoub, B. Balme, G. Tomasic, A. M. Di Giacomo, M. Maio, D. Schadendorf, I. Melero, B. Dréno, A. Khammari, R. Dummer, M. Levesque, Y. Koguchi, L. Fong, M. Lotem, M. Baniyash, H. Schmidt, I. M. Svane, G. Kroemer, A. Marabelle, S. Michiels, A. Cavalcanti, M. J. Smyth, J. S. Weber, A. M. Eggermont, L. Zitvogel
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The clinical management of metastatic melanoma requires predictors of the response to checkpoint blockade. Here, the authors use immunological assays to identify potential prognostic/predictive biomarkers in circulating blood cells and in tumor-infil
Externí odkaz: https://doaj.org/article/807762e56e0f4dbf9806c82c666da282
Zobrazit plný text záznamu
2
Expression of a hypoglycosylated form of CD86 (B7-2) on human T cells with altered binding properties to CD28 and CTLA-4
Autor: P Höllsberg, C Scholz, D E Anderson, E A Greenfield, V K Kuchroo, G J Freeman, D A Hafler
Publikováno v: The Journal of Immunology. 159:4799-4805
CD80 (B7-1) and CD86 (B7-2) on APC provide a major costimulatory signal through interactions with CD28 on T cells. Absent from resting human T cells, CD86 is up-regulated early upon T cell activation, whereas CD80 expression appears later. Whereas T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::325d3a410b408b8ad7dc8a8fc1e34dd5
https://doi.org/10.4049/jimmunol.159.10.4799
Zobrazit plný text záznamu
3
Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis
Autor: H Waldner, R A Sobel, E Howard, V K Kuchroo
Publikováno v: The Journal of Immunology. 159:3100-3103
Experimental autoimmune encephalomyelitis (EAE) is an organ-specific autoimmune disease inducible in susceptible animals by myelin Ag-specific CD4+ Th1 cells. The mechanisms by which these cells induce inflammation and demyelination in the central ne
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a372d25b8792b11f629cb9e1d135f2f
https://doi.org/10.4049/jimmunol.159.7.3100
Zobrazit plný text záznamu
4
B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors
Autor: E A Greenfield, E Howard, T Paradis, K Nguyen, F Benazzo, P McLean, P Höllsberg, G Davis, D A Hafler, A H Sharpe, G J Freeman, V K Kuchroo
Publikováno v: The Journal of Immunology. 158:2025-2034
The B7 family of costimulatory molecules provides the second signal necessary for activation of T cells. In the absence of the second signal, responding T cells become anergic. Although predominantly expressed on professional APCs, recent evidence sh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a5aeb739c656cf80df6f4e03683c031
https://doi.org/10.4049/jimmunol.158.5.2025
Zobrazit plný text záznamu
5
Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice
Autor: J A Encinas, M B Lees, R A Sobel, C Symonowicz, J M Greer, C L Shovlin, H L Weiner, C E Seidman, J G Seidman, V K Kuchroo
Publikováno v: The Journal of Immunology. 157:2186-2192
Experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, is a T cell-mediated autoimmune disease that can be induced in experimental animals by immunization with myelin Ags. Inbred strains of mice show varying degrees of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e21fe531a8798f5793c1e8c1c9362468
https://doi.org/10.4049/jimmunol.157.5.2186
Zobrazit plný text záznamu
6
Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein
Autor: J M Greer, R A Sobel, A Sette, S Southwood, M B Lees, V K Kuchroo
Publikováno v: The Journal of Immunology. 156:371-379
To understand and develop strategies to intervene in autoimmune responses to myelin proteolipid protein (PLP), encephalitogenic epitopes must be identified. To expedite the identification of potentially immunogenic and encephalitogenic epitopes of PL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f917a1978edd02de807110baf1f5a332
https://doi.org/10.4049/jimmunol.156.1.371
Zobrazit plný text záznamu
7
T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans
Autor: S Markovic-Plese, H Fukaura, J Zhang, A al-Sabbagh, S Southwood, A Sette, V K Kuchroo, D A Hafler
Publikováno v: The Journal of Immunology. 155:982-992
We investigated the immune response to proteolipid protein (PLP), the most abundant central nervous system myelin protein in humans. A total of 8207 short-term T cell lines were generated from 49 individuals, 39 patients with multiple sclerosis and 1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd4ef40c1cbf747afcad247b9b152bdc
https://doi.org/10.4049/jimmunol.155.2.982
Zobrazit plný text záznamu
8
Transfection of TCR alpha-chains into suppressor and T helper cell hybridomas. Production of suppressor factors with predicted antigen specificity
Autor: V K Kuchroo, M C Byrne, E Greenfield, M J Whitters, E A Nalefsky, A Rao, M Collins, M E Dorf
Publikováno v: The Journal of Immunology. 154:5030-5038
Conditioned medium from Ag-specific suppressor T cell hybridomas contains soluble factors (TsF) that modulate immune responses in an Ag-specific manner. We previously generated a series of TCR-alpha- and TCR-beta- expression variants from a 4-hydroxy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3df1b68a8622fce05dccd4bf0afc5d08
https://doi.org/10.4049/jimmunol.154.10.5030
Zobrazit plný text záznamu
9
T cell receptor alpha-chain defines the antigen specificity of antigen-specific suppressor factor but does not impart genetic restriction
Autor: R M O'Hara, M C Byrne, V K Kuchroo, A Nagelin, M J Whitters, S Jayaraman, S L Henderson, M E Dorf, M Collins
Publikováno v: The Journal of Immunology. 154:2075-2081
Previous studies utilizing NP (4-hydroxy, 3-nitrophenyl acetyl hapten)-specific, T suppressor hybridomas have indicated that expression of TCR-alpha, but not TCR-beta, mRNA is required for expression of Ag-specific suppressor factor bioactivity. Supp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a6b176f412a428ca56571a1dcba8257
https://doi.org/10.4049/jimmunol.154.5.2075
Zobrazit plný text záznamu
10
A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire
Autor: V K Kuchroo, J M Greer, D Kaul, G Ishioka, A Franco, A Sette, R A Sobel, M B Lees
Publikováno v: The Journal of Immunology. 153:3326-3336
Previously, six T cell clones, which are specific for an encephalitogenic determinant of myelin proteolipid protein (PLP) peptide residues 139 to 151 (HSLGKWLGHPDKF), were derived from SJL mice and shown to use diverse TCR genes. To design TCR antago
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a7948b14e0844b3f18bdd58890a733f
https://doi.org/10.4049/jimmunol.153.7.3326
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje