Zobrazeno 1 - 10
of 46
pro vyhledávání: '"V. J. Stella"'
Publikováno v:
Methods in molecular medicine. 23
The clinical development of orally active peptide drugs has been limited by their unfavorable physicochemical characteristics (e.g., charge, hydrogen bonding potential, size), which prevent them from permeating biological barriers such as the intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0a0e01ed31930e8a7f0fa84fc7368b7
https://pubmed.ncbi.nlm.nih.gov/21380890
https://pubmed.ncbi.nlm.nih.gov/21380890
Publikováno v:
Pharmaceutical research. 18(8)
The purpose of this study was to determine the osmolality of sulfobutylether (SBE) and hydroxypropyl (HP) derivatives of cyclodextrins (CDs) via vapor pressure osmometry (VPO) and freezing point depression (FPD). (SBE) and HP-CDs are efficient excipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2658a9344191e1d5a246a3801447820f
https://pubmed.ncbi.nlm.nih.gov/11587496
https://pubmed.ncbi.nlm.nih.gov/11587496
Publikováno v:
Pharmaceutical research. 18(5)
To understand the role of charge in substrate/cyclodextrin complexation by comparing the binding of neutral and charged substrates to a neutral cyclodextrin, such as hydroxypropyl beta-CD (HP-beta-CD) with 3.5 degrees of substitution, and an anionica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f0234d7c21f630251170147d96e9942
https://pubmed.ncbi.nlm.nih.gov/11465424
https://pubmed.ncbi.nlm.nih.gov/11465424
Publikováno v:
Pharmaceutical research. 17(8)
To understand the role of degree of substitution on binding of molecules to beta-Cyclodextrins (beta-CDs) with varying degrees of sulfobutyl ether (SBE) substitution.Using UV spectroscopy, complexation constants of molecules to SBE-beta-CDs were esti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9e8f6ae5e8e51e1035a47894f6da0b3
https://pubmed.ncbi.nlm.nih.gov/11028938
https://pubmed.ncbi.nlm.nih.gov/11028938
Publikováno v:
Journal of pharmaceutical sciences. 89(6)
The peptide boronic acid derivative 2-Pyz-(CO)-Phe-Leu-B(OH)(2) is a potent inhibitor of 20S proteasome and a proposed anticancer agent. During preformulation studies, the compound presented erratic stability behavior. Efforts were made to isolate an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4428f16bab09d44f28a36313b8da166
https://pubmed.ncbi.nlm.nih.gov/10824134
https://pubmed.ncbi.nlm.nih.gov/10824134
Publikováno v:
Journal of pharmaceutical sciences. 89(6)
The instability of vancomycin, a glycopeptide antibiotic, limits its shelf-life because the deamidation of its asparagine residue results in the formation of a zwitterion with limited aqueous solubility. Analysis of the pH-rate profile for vancomycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4140d2c6f1375920e3e23f6b7b45d7c
https://pubmed.ncbi.nlm.nih.gov/10824132
https://pubmed.ncbi.nlm.nih.gov/10824132
Publikováno v:
Journal of pharmaceutical sciences. 89(2)
The complexation of spironolactone (SP) with cyclodextrins (CDs) and the effect of pH on the CD catalyzed deacetylation of SP was studied in the presence of beta-cyclodextrin (beta-CD), hydroxypropyl-beta-cyclodextrin (HP-beta-CD), sulfobutylether-be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2088bde9431c46a3dc38e1cfed1941fd
https://pubmed.ncbi.nlm.nih.gov/10688753
https://pubmed.ncbi.nlm.nih.gov/10688753
Publikováno v:
Journal of pharmaceutical sciences. 89(2)
The purpose of this study was to evaluate and compare the potential use of two parenterally safe beta-cyclodextrins derivatives, (SBE)7m-beta-CD and HP-beta-CD, as solubilizers and stabilizers for melphalan and carmustine, two very unstable antineopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c64dd6a8166a40366434d58f574aaab7
https://pubmed.ncbi.nlm.nih.gov/10688757
https://pubmed.ncbi.nlm.nih.gov/10688757
Autor:
K, Okimoto, A, Ohike, R, Ibuki, O, Aoki, N, Ohnishi, T, Irie, K, Uekama, R A, Rajewski, V J, Stella
Publikováno v:
Pharmaceutical research. 16(4)
The purpose of this study was to develop a controlled-porosity osmotic pump tablet (OPT) which exhibits pH-independent release profiles for a basic drug using a sulfobutyl ether-beta-cyclodextrin, (SBE)7m-beta-CD, which acts as both a solubilizer and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c513665050ae2807ecca23b9e3195ff3
https://pubmed.ncbi.nlm.nih.gov/10227711
https://pubmed.ncbi.nlm.nih.gov/10227711
Publikováno v:
Pharmaceutical research. 15(10)
The purpose of this study was to develop a controlled-porosity osmotic pump tablet (OPT) for poorly water soluble drugs using a sulfobutyl ether-beta-cyclodextrin, (SBE)7m-beta-CD or Captisol, which acted as both a solubilizer and as an osmotic agent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ce3c742482254250a88e3003283d5ca
https://pubmed.ncbi.nlm.nih.gov/9794499
https://pubmed.ncbi.nlm.nih.gov/9794499