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Increased Ca-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

Autor: R. Zaremba, Kornelia Jaquet, V. J. Owen, Nicky M. Boontje, Zoltán Papp, J. van der Velden, P. Goldmann, Ger J.M. Stienen, P. B.J. Burton, J. W. de Jong

Publikováno v: Cardiovascular Research. 57:37-47

Objective: The alterations in contractile proteins underlying enhanced Ca2+-sensitivity of the contractile apparatus in end-stage failing human myocardium are still not resolved. In the present study an attempt was made to reveal to what extent prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e43db18ccb117f3d15932b1a81cc5a3b
https://doi.org/10.1016/s0008-6363(02)00606-5

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Activation of Apoptotic and Inflammatory Pathways in Dysfunctional Donor Hearts1

Autor: Najma Latif, Nicholas R. Banner, Asghar Khaghani, V. J. Owen, Ariela Pomerance, Paul S. J. Burton, Angela O’Halloran, Magdi H. Yacoub, Emma J. Birks

Publikováno v: Transplantation. 70:1498-1506

Background. Myocardial dysfunction is common after brain death, but the mechanisms remain unclear. Apoptosis is tightly regulated by enzymes termed the caspases. We have investigated the caspases involved in the terminal part of the apoptotic pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8460cec8f1686d533b405d14f7ebf793
https://doi.org/10.1097/00007890-200011270-00018

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Tumor Necrosis Factor-α Is Expressed in Donor Heart and Predicts Right Ventricular Failure After Human Heart Transplantation

Autor: Paul B. J. Burton, Julia M. Polak, Emma J. Birks, Magdi H. Yacoub, Nicholas R. Banner, Anne E. Bishop, V. J. Owen, Asghar Khaghani

Publikováno v: Circulation. 102:326-331

Background —Myocardial failure is an important problem after heart transplantation. Right ventricular (RV) failure is most common, although its mechanisms remain poorly understood. Inflammatory cytokines play an important role in heart failure. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05183a41751f78799b1ab08130810460
https://doi.org/10.1161/01.cir.102.3.326

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Relationship between depolarization-induced force responses and Ca2+ content in skeletal muscle fibres of rat and toad

Autor: M W Fryer, V J Owen, D G Stephenson, Graham D. Lamb

Publikováno v: The Journal of Physiology. 498:571-586

1. The relationship between the total Ca2+ content of a muscle fibre and the magnitude of the force response to depolarization was examined in mechanically skinned fibres from the iliofibularis muscle of the toad and the extensor digitorum longus mus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61ef349d72d300bc71b605b1739056a
https://doi.org/10.1113/jphysiol.1997.sp021884

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Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteins

Autor: J, van der Velden, Z, Papp, R, Zaremba, N M, Boontje, J W, de Jong, V J, Owen, P B J, Burton, P, Goldmann, K, Jaquet, G J M, Stienen

Publikováno v: Cardiovascular research. 57(1)

The alterations in contractile proteins underlying enhanced Ca(2+)-sensitivity of the contractile apparatus in end-stage failing human myocardium are still not resolved. In the present study an attempt was made to reveal to what extent protein altera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::779074626a3d59302e7c664f9b87b681
https://pubmed.ncbi.nlm.nih.gov/12504808

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Calcium sensitivity of force in human ventricular cardiomyocytes from donor and failing hearts

Autor: P. B.J. Burton, F. C. Visser, V. J. Owen, J. W. de Jong, Zoltán Papp, Ger J.M. Stienen, J. van der Velden, L. J. Klein, Nicky M. Boontje

Publikováno v: Europe PubMed Central
Basic Research in Cardiology, Supplement, 97(1), 118-126. D. Steinkopff-Verlag
Van Der Velden, J, Boontje, N M, Papp, Z, Klein, L J, Visser, F C, De Jong, J W, Owen, V J, Burton, P B J & Stienen, G J M 2002, ' Calcium sensitivity of force in human ventricular cardiomyocytes from donor and failing hearts ', Basic Research in Cardiology, Supplement, vol. 97, no. 1, pp. 118-126 .

In failing human myocardium changes occur, in particular, in isoform composition and phosphorylation level of the troponin T (TnT) and troponin I (TnI) subunits of the actin filament and the myosin light chains (MLC-1 and -2), but it is unclear to wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775d2b1855220c7d81891624ee5cfd8a
https://pubmed.ncbi.nlm.nih.gov/12479245

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Quantitative Myocardial Cytokine Expression and Activation of the Apoptotic Pathway in Patients Who Require Left Ventricular Assist Devices

Autor: Nicholas R. Banner, Paul J.R. Barton, Anthony J. Mullen, Leanne E. Felkin, John Pepper, V. J. Owen, Christopher Bowles, Najma Latif, Julia M. Polak, Magdi H. Yacoub, Asghar Khaghani, Emma J. Birks

Publikováno v: Europe PubMed Central

Background Molecular mechanisms underlying the deterioration of patients undergoing LV assist device (LVAD) implantation remain poorly understood. We studied the cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-1β and IL-6 and the termi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10e6799d2bd82517c0efbdee00966a0
https://doi.org/10.1161/circ.104.suppl_1.i-233

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Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure

Autor: Paul B. J. Burton, Magdi H. Yacoub, Paul J.R. Barton, Emma J. Birks, Antony J. Mullen, V. J. Owen

Publikováno v: European heart journal. 22(12)

Regulators of G-protein Signalling (RGS) proteins have been shown to limit in vitro signalling of G proteins. In common with end-stage heart failure, we have recently shown that upregulation of the inhibitory G-protein, Gialpha, occurs in acutely fai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a7719511afb7a827bd23c9c247df45
https://pubmed.ncbi.nlm.nih.gov/11428836

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Elevated tumor necrosis factor-alpha and interleukin-6 in myocardium and serum of malfunctioning donor hearts

Autor: Emma J. Birks, Paul B. J. Burton, V. J. Owen, Magdi H. Yacoub, Nicholas R. Banner, Paul J.R. Barton, Diane Hunt, Antony J. Mullen

Publikováno v: Europe PubMed Central

Background —Myocardial dysfunction is a common and important problem in donor hearts. The mechanisms responsible remain unclear. We have studied the cytokines tumor necrosis factor (TNF)-α and interleukin-6 (IL-6) in the myocardium and serum from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cc75d1fc6d8fb4ddda572bd70bb746
https://pubmed.ncbi.nlm.nih.gov/11082413

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