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Effects of treatment with megestrol acetate, aminoglutethimide, or formestane on insulin-like growth factor (IGF) I and II, IGF-binding proteins (IGFBPs), and IGFBP-3 protease status in patients with advanced breast cancer

Autor: J. W. J. Van Der Stappen, V. J. Frost, Jeffrey M P Holly, Per Eystein Lønning, S. I. Helle

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 81:2216-2221

The effects of treatment with the aromatase inhibitors aminoglutethimide (AG) and formestane or the synthetic progestin megestrol acetate (MA) on plasma levels of insulin-like growth factor I (IGF-1), IGF-II, IGF-binding proteins (IGFBPs), and IGFBP-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78dace50a14feee8cdb543d715372e9e
https://doi.org/10.1210/jcem.81.6.8964854

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Proteolytic modification of insulin-like growth factor-binding proteins: comparison of conditioned media from human cell lines, circulating proteases and characterized enzymes

Autor: J. A. H. Wass, V. M. Macaulay, Jeffrey M P Holly, V. J. Frost

Publikováno v: Journal of Endocrinology. 138:545-554

Proteolytic modification of circulating insulin-like growth factor binding protein-3 (IGFBP-3) has been described in a number of conditions. Using Western ligand blotting and SDS-PAGE analysis of fragmentation patterns of 125I-labelled IGFBP-3 and 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebfa2a82f8d4f78c324ac9c00af3751
https://doi.org/10.1677/joe.0.1380545

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Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Autor: Stefano Cianfarani, Jeffrey M P Holly, Martin O. Savage, V. J. Frost

Publikováno v: Experientia. 49(8)

The insulin-like growth factors (IGFs) circulate bound to specific proteins (termed IGFBP-1 through IGFBP-6) that modulate IGF bioactivity in tissues. The aim of this study was to analyse the effects of glucose on IGF binding to IGFBPs in rat and hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678303eac85794716a76a6aa746461bd
https://pubmed.ncbi.nlm.nih.gov/7689487

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Cytokines modulate the sensitivity of human fibroblasts to stimulation with insulin-like growth factor-I (IGF-I) by altering endogenous IGF-binding protein production

Autor: Jeffrey M P Holly, Yateman Me, J. A. H. Wass, S. C. Cwyfan Hughes, Claffey Dc, V. J. Frost

Publikováno v: The Journal of endocrinology. 137(1)

Human dermal fibroblasts produce a number of insulin-like growth factor-binding proteins (IGFBPs) including the main circulating form, IGFBP-3. It has been suggested that the regulation of IGFBP secretion may play a major role in modulating insulin-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::535b635bab55a3b33410c0747d1da0c0
https://pubmed.ncbi.nlm.nih.gov/7684061

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