Inhibition of mutagenic activation of orthoaminoazotoluene increases its carcinogenicity for mouse liver

Autor: V. I. Kaledin, L. P. Ovchinnikova, S. I. Ilnitskaya, T. S. Morozkova, N. A. Popova

Publikováno v: Вавиловский журнал генетики и селекции, Vol 20, Iss 5, Pp 708-715 (2016)

Various mutationally impaired genes are often found in malignant tumors of animals and humans. At the same time, a large number of carcinogens demonstrate positive activity in different in vitro tests for mutagenicity. These findings are indicative o

Externí odkaz: https://doaj.org/article/19661c9b9bef4ba4abff900206215487

Induction of tyrosine aminotransferase in mice is inhibited by activated metabolites of ortho- aminoazotoluene

Autor: V. I. Kaledin, S. I. Ilnitskaya, N. A. Popova, O. A. Koval, I. A. Pyshnaya, L. F. Gulyaeva

Publikováno v: Вавиловский журнал генетики и селекции, Vol 19, Iss 1, Pp 136-143 (2015)

Aminoazo dyes and other hepatocarcinogenic substances inhibit glucocorticoid-mediated induction of adaptive enzymes, including tyrosine aminotransferase (TAT), in mouse and rat liver. There is a specific relationship between the effect of a carcinoge

Externí odkaz: https://doaj.org/article/cb3f9b23b143469da3919982ddfd0520

The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo

Autor: Valery P. Nikolin, Nelly A. Popova, Olga A. Luzina, Nariman F. Salakhutdinov, Alexandra L. Zakharenko, V. I. Kaledin, Olga I. Lavrik

Publikováno v: Clinical & Experimental Metastasis. 38:431-440

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a repair enzyme for 3'-end DNA lesions, predominantly stalled DNA-topoisomerase 1 (Top1) cleavage complexes. Tdp1 is a promising target for anticancer therapy based on DNA damage caused by Top1 poisoning. Ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66250fb3526f3b296277a5b65b3b4938
https://doi.org/10.1007/s10585-021-10113-y

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

Autor: Jóhannes Reynisson, Raina Chand, Daniel M Ayine-Tora, Valeriy P. Nikolin, Olga D. Zakharova, Ekaterina S Ilina, Dina V. Korchagina, Olga I. Lavrik, Jinal Patel, Alexandra L. Zakharenko, N.F. Salakhutdinov, Arina A Chepanova, V. I. Kaledin, T. M. Khomenko, Konstantin P. Volcho, Ivanhoe K. H. Leung, Nelly A Popova

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 1, p 126 (2019)
International Journal of Molecular Sciences; Volume 21; Issue 1; Pages: 126
International Journal of Molecular Sciences

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new chemosensitizing agents due to its ability to remove DNA damage caused by topoisomerase 1 (To

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434d11256c0b6dbe50e09af9e1ea6980
https://www.mdpi.com/1422-0067/21/1/126

Stimulation of Diethylnitrosamine Metabolism Reduces Its General Toxic and Hepatocarcinogenic Effects

Autor: S. I. Ilnitskaya, V. I. Kapustina, V. I. Kaledin, A. Yu. Grishanova, T. S. Morozkova, L. A. Bogdanova, M. L. Perepechaeva

Publikováno v: Bulletin of Experimental Biology and Medicine. 162:98-101

The general toxic and hepatocarcinogenic effects of diethylnitrosamine after stimulation of its metabolism with 1,4-bis[2-(3,5-dichloropyridyloxy)]-benzene (TCPOBOP) were studied. The hydroxylating activity of liver microsomes of C57Bl/6Mv mice towar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e50794b9023e7f6f37f63a1eab917c
https://doi.org/10.1007/s10517-016-3555-3