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Preservation of Somatostatin Receptors Coupled to the Inhibition of Adenylate Cyclase in the Cortex and Hippocampus in Senile Dementia of the Alzheimer Type

Autor: E. C. Hirsch, F. Javoy-Agid, A. Slama, P. Cervera, V. Heidet, J. Epelbaum

Publikováno v: Dementia and Geriatric Cognitive Disorders. 2:88-94

The distribution and the density of 125I-Tyr0-DTrp8-somatostatin (125I-SRIF) binding sites were compared by quantitative radioautography in the hippocampi and entorhinal cortices from normal humans and patients with senile dementia of the Alzheimer t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60d69a93ef59bfd0db57e4570fa524e2
https://doi.org/10.1159/000107181

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Pharmacodynamic and pharmacokinetic profile of S 17092, a new orally active prolyl endopeptidase inhibitor, in elderly healthy volunteers. A phase I study

Autor: P, Morain, J L, Robin, G, De Nanteuil, R, Jochemsen, V, Heidet, D, Guez

Publikováno v: British journal of clinical pharmacology. 50(4)

The aim of this study was to characterize the pharmacodynamics and the pharmacokinetics of S 17092, a new orally active prolyl endopeptidase inhibitor following single and repeated administration in elderly healthy volunteers.This was a double-blind,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b04847b55e08db755167d59c07f6ee6
https://pubmed.ncbi.nlm.nih.gov/11012558

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Comparative effects of aging process on phosphatidylcholine biosynthesis pathway: a key role for CTP-phosphocholine cytidylyltransferase?

Autor: V. Heidet, J. M. Lepagnol

Publikováno v: Annals of the New York Academy of Sciences. 695

The effects of aging on phosphatidylcholine (PtdCho) biosynthesis were investigated in liver and brain subcellular fractions of the rat, by studying the activity and regulation of CTP phosphocholine cytidylyltransferase (CT), the rate limiting enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85eca900b99791df752e370672d2c75
https://pubmed.ncbi.nlm.nih.gov/8239319

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Functional maturation of somatostatin neurons and somatostatin receptors during development of mouse hypothalamus in vivo and in vitro

Autor: V. Heidet, Annie Faivre-Bauman, Claude Kordon, Jacques Epelbaum, S. Rasolonjanahary, Catherine Loudes

Publikováno v: Brain research. Developmental brain research. 57(1)

Ontogenesis of somatostatin (SRIF) neurons and receptors was studied in fetal hypothalamic cell cultures kept in serum-free medium, and compared to the in vivo developmental pattern. Initial rise in neuronal content of SRIF occurred later in vitro th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8531464b1a2237b1909e641bd8bd78f
https://pubmed.ncbi.nlm.nih.gov/1982527

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Structural identification of prostaglandin A1 biotransformation products from tumor cells

Autor: Nadine Nagel, V. Heidet, Fernand Dray, A. Gouyette, B. Vuelliez-Le Normand

Publikováno v: Prostaglandins. 35:515-521

Rat B104 neuroblastoma and C6 glioma cells are able to metabolize prostaglandin A1 (PGA1). Four metabolites were isolated by high performance liquid chromatography. Their structure was elucidated by fast atom bombardment mass spectrometry and 1H nucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::481d1b25d39573a179814851c006f665
https://doi.org/10.1016/0090-6980(88)90027-5

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Tumor cell biotransformation products of prostaglandin A1 with growth inhibitory activity

Autor: Edith Gouin, V. Heidet, Nadine Nagel, F. Dray, B. Vulliez-le Normand, A. Gouyette

Publikováno v: Biochemical and biophysical research communications. 141(3)

Summary The growth inhibitory effect and the fate of prostaglandin A 1 (10 −6 M) were followed in cultures of rat B104 neuroblastoma and C6 glioma cells. More than 40% and 85% of the drug were neither recognized by a prostaglandin A 1 antiserum nor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266d37b4aca541de1b83b7b34c258390
https://pubmed.ncbi.nlm.nih.gov/3814122

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Somatostatin receptors in brain and pituitary

Autor: Alain Enjalbert, F. Peillon, V. Heidet, Jacques Epelbaum, P. Bertrand, J.F. Léonard, E. Moyse, Claude Kordon, A. Slama, Y. Agid, A. Beaudet, F. Musset, F. Agid, Catherine Videau, S. Krantic

Publikováno v: Scopus-Elsevier

Somatostatin (SRIF) actions in the brain and pituitary are mediated by specific receptors. Using radioiodinated ligands it has been possible to characterize the kinetics of specific binding sites in the brain and pituitary, and to determine their cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc9e4a0a77472250bd58936e5a6dc42
https://pubmed.ncbi.nlm.nih.gov/2566573

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