GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

Autor: A. Jaspart, C. Calmels, O. Cosnefroy, P. Bellecave, P. Pinson, S. Claverol, V. Guyonnet-Dupérat, B. Dartigues, M. S. Benleulmi, E. Mauro, P. A. Gretteau, V. Parissi, M. Métifiot, M. L. Andreola

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)

Abstract GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection. Herein, we identified HIV-1 inte

Externí odkaz: https://doaj.org/article/998828727f8e4d62a97fb16cfbfb7dc4

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GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

Autor: A, Jaspart, C, Calmels, O, Cosnefroy, P, Bellecave, P, Pinson, S, Claverol, V, Guyonnet-Dupérat, B, Dartigues, M S, Benleulmi, E, Mauro, P A, Gretteau, V, Parissi, M, Métifiot, M L, Andreola

Publikováno v: Scientific Reports

GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection. Herein, we identified HIV-1 integrase as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bb70f351cc2eee272e3be3eae717351
https://pubmed.ncbi.nlm.nih.gov/28536474

CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells

Autor: J. Boutin, J. Rosier, D. Cappellen, F. Prat, J. Toutain, P. Pennamen, J. Bouron, C. Rooryck, J. P. Merlio, I. Lamrissi-Garcia, G. Cullot, S. Amintas, V. Guyonnet-Duperat, C. Ged, J. M. Blouin, E. Richard, S. Dabernat, F. Moreau-Gaudry, A. Bedel

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

CRISPR-Cas9 generates double-strand breaks, which pose a threat to genome integrity. Here the authors show loss of heterozygosity in edited hematopoietic progenitor cells.

Externí odkaz: https://doaj.org/article/e2a0368b510f4b0f8a6f33bea02556ca

Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family

Autor: J L, Desseyn, V, Guyonnet-Dupérat, N, Porchet, J P, Aubert, A, Laine

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 1997, 272, pp.3168-3178. ⟨10.1074/jbc.272.6.3168⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 1997, 272, pp.3168-3178. ⟨10.1074/jbc.272.6.3168⟩

The article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.; International audience; Human mucin gene MUC5B is mapped clustered with MUC6, MUC2, and MUC5AC on chromosome 11p1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::04434d41c68f345e203a50c0c7e08a54
https://hal.univ-lille.fr/hal-02177070