Zobrazeno 1 - 10
of 14
pro vyhledávání: '"V. Guru KrishnaKumar"'
Publikováno v:
International Journal of Biological Macromolecules. 138:168-180
Polyphenols have been suggested as potential therapeutic agents for the treatment of amyloidogenic diseases. In this work, we evaluate quercetin-rich onion extract for its ability to inhibit tau fibrillization. Considering the presence of polyphenols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12643b300bb095d46a8344395c5ae75d
https://doi.org/10.1016/j.ijbiomac.2019.07.081
https://doi.org/10.1016/j.ijbiomac.2019.07.081
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1862:2590-2604
Background Carbamylation is a non-enzymatic post-translational modification (PTM), which involves the covalent modification of N-terminus of protein or e-amino group of Lys. The role of carbamylation in several age-related disorders is well documente
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6335fbbb7ba2d98f42fa820bd3400dcc
https://doi.org/10.1016/j.bbagen.2018.07.030
https://doi.org/10.1016/j.bbagen.2018.07.030
Publikováno v:
Sensors and Actuators B: Chemical. 244:673-683
New synthetic strategy to synthesize α-methyl BODIPY derivatives from dipyrromethanes is reported. The method involves regioselective formylation of dipyrromethane followed by modified Wolff-Kishner reduction. The photophysical, electrochemical and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc38a7af31b9ac7289290c6466e8fcb3
https://doi.org/10.1016/j.snb.2016.12.104
https://doi.org/10.1016/j.snb.2016.12.104
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of Alzheimer’s disease (AD), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded β-sheet rich aggregates. Therefore, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fefea6fe7db2418a31a3d11e023169
http://europepmc.org/articles/PMC5758761
http://europepmc.org/articles/PMC5758761
Publikováno v:
RSC Advances. 5:104417-104425
In Solid Phase Peptide Synthesis (SPPS), contamination with deletion sequences which often co-elute with the target peptide continues to be a major challenge as these impurities can significantly affect the target peptide's properties. Here, we repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d2ec56093e98a0b25fe5f5283af03a
https://doi.org/10.1039/c5ra23441g
https://doi.org/10.1039/c5ra23441g
Autor:
Ehud Gazit, Hamutal Engel, Daniel L. Segal, Edward Pichinuk, Yelena Losev, V. Guru KrishnaKumar, Avi Raveh, Esraa Haj
Publikováno v:
Biochimica et biophysica acta. General subjects. 1862(7)
Background Alzheimer's disease (AD) is the most common neurodegenerative disorder which is characterized by the deposits of intra-cellular tau protein and extra-cellular amyloid-β (Aβ) peptides in the human brain. Understanding the mechanism of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45de6e704826a5cb9fea7e5230ebb08
https://pubmed.ncbi.nlm.nih.gov/29634991
https://pubmed.ncbi.nlm.nih.gov/29634991
Autor:
Sharad Gupta, V. Guru KrishnaKumar
Publikováno v:
Preparative biochemistrybiotechnology. 47(5)
Tau is an intrinsically disordered protein responsible for maintaining the structure and stability of axonal microtubules. However, in certain disease conditions including Alzheimer's disease, tau protein may undergo biochemical and structural change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65befd1a777a280557a8a6fc571c8776
https://pubmed.ncbi.nlm.nih.gov/28045602
https://pubmed.ncbi.nlm.nih.gov/28045602
Autor:
V. Guru KrishnaKumar, Gupta, Sharad
Tau is an intrinsically disordered protein responsible for maintaining the structure and stability of axonal microtubules. However, in certain disease conditions including Alzheimer’s disease, tau protein may undergo biochemical and structural chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1344259ae6a909adea3bbe330aa32b70
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