Zobrazeno 1 - 10
of 75
pro vyhledávání: '"V. G. Wilson"'
Publikováno v:
Current Vascular Pharmacology. 18:43-49
Objective: To study the distribution of nitric oxide synthase (NOS) isoforms and protein levels in human haemorrhoids and rectal tissue. Methods: Protein expression of NOS1, NOS2 and NOS3 was compared between haemorrhoids (n=14) and normal rectal sub
Publikováno v:
British Journal of Pharmacology. 174:569-579
Objectives: Haemorrhoids is a common anorectal condition that affects millions worldwide. We studied the potential role of ET-1 and its (ETA and ETB) receptors in haemorrhoid tissue. Methods: ET-1, ETA and ETB receptor localisation was studied in hae
Publikováno v:
Pharmacological Research. 63:490-495
Haemorrhoids is associated with high blood flow of the anorectal region. The question of whether pharmacological manipulation of vascular supply can relieve the symptoms of haemorrhoids has been raised. In order to undertake this type of clinical inv
Autor:
David A. Hughes, Moira A. Taylor, Sandra Tribolo, Paul W. Needs, Paul A. Kroon, V. G. Wilson, Sunita Suri, Salmin Alshalmani
Publikováno v:
British Journal of Pharmacology. 162:1485-1497
BACKGROUND AND PURPOSE Quercetin is anti-inflammatory in macrophages by inhibiting lipopolysaccharide (LPS)-mediated increases in cytokine and nitric oxide production but there is little information regarding the corresponding effect on the vasculatu
Autor:
V. G. Wilson, H. J. Gruss, Dashwood, J Simpson, Austin G. Acheson, S. J. Rayment, T. Eames, John H Scholefield, Y. Henry
Publikováno v:
British Journal of Pharmacology. 160:1727-1740
BACKGROUND AND PURPOSE We have investigated the distribution of α-adrenoceptors in sheep internal anal sphincter (IAS), as a model for the human tissue, and evaluated various imidazoline derivatives for potential treatment of faecal incontinence. EX
Autor:
Sandra Tribolo, Sunita Suri, Moira A. Taylor, V. G. Wilson, Paul A. Kroon, XH Liu, David A. Hughes, Paul W. Needs, S. J. Rayment
Publikováno v:
British Journal of Pharmacology. 159:566-575
Background and purpose: Quercetin is a major flavonoid that contributes to the reduced risk of cardiovascular disease associated with dietary ingestion of fruits and vegetables. We have pharmacologically characterized the effect of quercetin, and its
Autor:
Sunita Suri, Moira A. Taylor, V. G. Wilson, Paul A. Kroon, David A. Hughes, Paul W. Needs, Anne Verity, Sandra Tribolo
Publikováno v:
Biochemical Pharmacology. 76:645-653
Exposure of neutrophils to either lipopolysaccharide (LPS) or N -formyl-methionyl-leucyl-phenylalanine (fMLP) is associated with changes in the expression of cell adhesion molecules and elevation of intracellular calcium ions. Although dietary flavon
Publikováno v:
British Journal of Anaesthesia. 100:612-621
Background The aim of this study was to investigate the effects of procalcitonin on the lipopolysaccharide (LPS)-induced changes in human leucocytes and porcine isolated coronary artery. Methods Using flow cytometry, changes in forward scatter and in
Autor:
David A. Hughes, Sandra Tribolo, Federica Lodi, Paul W. Needs, Moira A. Taylor, Sunita Suri, Carol Connor, Paul A. Kroon, V. G. Wilson
Publikováno v:
Atherosclerosis. 197:50-56
Adhesion of circulating monocytes to vascular endothelial cells, a critical step in both inflammation and atherosclerosis, is mediated by cross-linkage of adhesion molecules expressed on the surface of both cell types. Dietary flavonoids have been sh
Autor:
M. Jonas‐Obichere, M K Mundey, H. Tyler, V. G. Wilson, Austin G. Acheson, John H. Scholefield
Publikováno v:
British Journal of Surgery. 92:1263-1269
Background Chronic anal fissure is associated with considerable pain and anal hypertonia. Numerous clinical studies attest to the effectiveness of individual nitro-containing drugs and organic calcium channel blockers in this condition but there are