Výsledky vyhledávání - "V. G. Pugachev"

Kinetics of inactivation of staphylolytic enzymes: Qualitative and quantitative description

Autor: V. G. Pugachev, Georgy Emelianov, Steven M. Swift, T. A. Chubar, Natalia Klaychko, L.Y. Filatova, David M. Donovan

Publikováno v: Biochimie. 162:77-87

Lysin 2638aR and chimeric Ply187AN-KSH3b fusion protein are capable of lysing antibiotic-resistant strains of Staphylococcus aureus and are promising alternatives to antibiotics. Studies on the stability and structure of lysins 2638aR and Ply187AN-KS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e95807b6953f70ba62bd52c1ccb0ec
https://doi.org/10.1016/j.biochi.2019.04.005

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Influence of Different Types of Block Copolymers on the Secondary Structure and Stability of the Staphylolytic Lysk Enzyme

Autor: I. A. Novozhilov, N. G. Balabushevich, L.Y. Filatova, Natalia L. Klyachko, V. G. Pugachev, David M. Donovan, T. A. Chubar

Publikováno v: Moscow University Chemistry Bulletin. 73:179-184

A branched block copolymer of polyethyleneimine and polyethylene glycol (PEI–PEG) and a linear block copolymer of polylysine and polyethylene glycol (PLL–PEG) form complexes with the staphylolytic LysK enzyme. The complexation between LysK and ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15ad85ebc61a0698b89dab319ea06a42
https://doi.org/10.3103/s0027131418040028

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A Chimeric LysK-Lysostaphin Fusion Enzyme Lysing Staphylococcus aureus Cells: a Study of Both Kinetics of Inactivation and Specifics of Interaction with Anionic Polymers

Autor: David M. Donovan, L.Y. Filatova, Dmitrieva Nf, V. G. Pugachev, Nadezda G. Balabushevich, Nadiya T. Ishnazarova, Juli Foster-Frey, Natalia L. Klyachko, Stephen C. Becker

Publikováno v: Applied Biochemistry and Biotechnology. 180:544-557

A staphylolytic fusion protein (chimeric enzyme K-L) was created, harboring three unique lytic activities composed of the LysK CHAP endopeptidase, and amidase domains, and the lysostaphin glycyl-glycine endopeptidase domain. To assess the potential o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70dc8f66d1c63fb303d8d74598bd223
https://doi.org/10.1007/s12010-016-2115-7

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Lytic enzymes of staphylococcal phages: Correlation between secondary structure and stability

Autor: J. A. Foster-Frey, David M. Donovan, N. L. Klyachko, L.Y. Filatova, V. G. Pugachev, Elena V. Kudryashova

Publikováno v: Moscow University Chemistry Bulletin. 71:7-11

Lytic enzymes of bacteriophages K, phi11, and phi80α can lyse (destroy) cells of antibiotic-resistant strains of Staphylococcus aureus, which makes these enzymes promising antimicrobial agents. The stability of recombinant lysins of phages K, phi11,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f87fb862f2e07220aef932aa78d31e90
https://doi.org/10.3103/s002713141601003x

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Bacteriophage phi11 lysin: Physicochemical characterization and comparison with phage phi80α lysin

Autor: Alexander V. Kabanov, Juli Foster-Frey, Natalia L. Klyachko, Dmitrieva Nf, L.Y. Filatova, V. G. Pugachev, David M. Donovan, T. A. Chubar

Publikováno v: Enzyme and Microbial Technology. :51-58

Phage lytic enzymes are promising antimicrobial agents. Lysins of phages phi11 (LysPhi11) and phi80α (LysPhi80α) can lyse (destroy) cells of antibiotic-resistant strains of Staphylococcus aureus. Stability of enzymes is one of the parameters making

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8e00992338539d89f094de7076b33e
https://doi.org/10.1016/j.enzmictec.2015.03.005

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Peptidoglycan degrading activity of the broad-range Salmonella bacteriophage S-394 recombinant endolysin

Autor: Ksenia Yu Vlasova, Konstantin A. Miroshnikov, Mikhail M. Shneider, Natalia L. Klyachko, A.D. Priyma, S.A. Legotsky, Alexander V. Kabanov, V. G. Pugachev, Olga D. Totmenina

Publikováno v: Biochimie.

The use of bacteriophage endolysins as specific antibacterial agents is a prospective strategy to treat bacterial infections caused by antibiotic-resistant pathogens. In case of Gram-negative species this strategy has limited applications since outer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e80993596bac7efbe4e2b1c21c078d
https://pubmed.ncbi.nlm.nih.gov/25241254

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[Design of the composition of baculovirus agents]

Autor: A V, Kolosov, V G, Pugachev, G G, Anan'ko, O D, Totmenina, N L, Kliachko, P A, Levashev, T A, Kosogova

Publikováno v: Voprosy virusologii. 56(5)

The ability of 30 compounds to protect infection bacteria and baculoviruses from the damaging effect of ultraviolet (UV) irradiation was investigated. For this B. thuringiensis var. israelensis spores and gypsy moth (Lymantria dispar L.) nuclear poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abcc6dd44d285b3b607b472cd7c7eae4
https://pubmed.ncbi.nlm.nih.gov/22171478

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[Double-stranded RNA from phage F6: its interferon-inducing and antiviral properties]

Autor: N N, Nosik, V G, Pugachev, F I, Ershov

Publikováno v: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 35(3)

Double stranded RNA was isolated from bacteriophage phi 6 parasitizing on phytobacteria. Its interferon-inducing and antiviral activities were shown in vitro and in vivo. In the culture of L-929 cells, interferon resistant to heat and acids was synth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c60e48573a91fdfe84bb9b8eec551495
https://pubmed.ncbi.nlm.nih.gov/1694424

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