Zobrazeno 1 - 10
of 25
pro vyhledávání: '"V. C. Menys"'
Publikováno v:
Scandinavian Journal of Haematology. 33:486-491
The myelodysplastic syndromes (MDS) are characterised by dysplastic marrow and cytopenia. Clinically detectable bleeding is uncommon and usually attributed to thrombocytopenia. We have investigated some aspects of haemostatic function in 17 patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098248b8cc12619c88c52684ab51015f
https://doi.org/10.1111/j.1600-0609.1984.tb00730.x
https://doi.org/10.1111/j.1600-0609.1984.tb00730.x
Autor:
V C Menys
Publikováno v:
Platelets. 5:156-161
The aim of this study was to determine the contribution of increased PGD(2) formation to the anti-aggregatory action of a thromboxane A(2) (TXA(2)) synthase inhibitor and TP receptor antagonist (ZD1542) against collagen-induced human platelet aggrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb3dcf7e4650c6d6644d5f289367502
https://doi.org/10.3109/09537109409005529
https://doi.org/10.3109/09537109409005529
Autor:
V C Menys
Publikováno v:
Platelets. 6(2)
The DP receptor-dependence of inhibition of platelet aggregation (PA), degranulation, and TXA(2) synthesis, by PGD(2), in human whole blood, has not been established since selective antagonists have only recently been developed. Accordingly, the effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c89012336f7beda3a00c5e619b80f8
https://pubmed.ncbi.nlm.nih.gov/21043700
https://pubmed.ncbi.nlm.nih.gov/21043700
Autor:
V C, Menys, P N, Durrington
Publikováno v:
British journal of pharmacology. 139(5)
Squalene synthase is the enzyme that converts farnesyl pyrophosphate to squalene in the cholesterol biosynthesis pathway. We examined the lipid-lowering properties of 1-[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::68e16f6ff0f6002e1b2e853fcd5e27c9
https://pubmed.ncbi.nlm.nih.gov/12839864
https://pubmed.ncbi.nlm.nih.gov/12839864
Autor:
Paul N. Durrington, V C Menys
Publikováno v:
British Journal of Pharmacology. 139:881-882
HMG-CoA reductase inhibitors (statins) reduce cardiovascular disease morbidity and mortality with a high level of safety. Nonetheless, there are substantial numbers of people who either do not tolerate statins or whose low-density lipoprotein (LDL) l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::113179a37c40017d317b4cab3c05f9ee
https://doi.org/10.1038/sj.bjp.0705331
https://doi.org/10.1038/sj.bjp.0705331
Publikováno v:
Thrombosis and haemostasis. 72(4)
We determined changes in platelet aggregability following cardiopulmonary bypass, using optical aggregometry to assess macroaggregation in platelet-rich plasma (PRP), and platelet counting to assess microaggregation both in whole blood and PRP. Hirud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54145fe477188e4c26e2fb875ede10e4
https://pubmed.ncbi.nlm.nih.gov/7533335
https://pubmed.ncbi.nlm.nih.gov/7533335
Autor:
J A Davies, V C Menys
Publikováno v:
Thrombosis and Haemostasis. 49:096-101
SummaryPlatelet adhesion to rabbit aortic subendothelium or collagen-coated glass was quantitated in a rotating probe device by uptake of radio-labelled platelets. Under conditions in which aspirin had no effect, dazoxiben, a selective inhibitor of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db6e42f21a4579d143cbf1d80f989c94
https://doi.org/10.1055/s-0038-1657330
https://doi.org/10.1055/s-0038-1657330
Autor:
V. C. Menys, J. A. Davies
Publikováno v:
Clinical Science. 65:149-153
1. The effects of ZK 36374, a prostacyclin analogue, were studied on adhesion of rabbit platelets to damaged rabbit aorta and on activation of platelets (judged by release of serotonin and formation of thromboxane-B2) in response to the processes of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5c09cc51ae7b6cf4bacb6df4269c57
https://doi.org/10.1042/cs0650149
https://doi.org/10.1042/cs0650149
Autor:
J A Davies, V C Menys
Publikováno v:
Oral Presentations.
Vasoconstriction and platelet aggregation in response to thromboxane A2 are thought to be important in thrombo- genesis. We assessed the effects of inhibition of thromboxane synthesis using UK37248 on platelet monolayer adhesion. This was quantitated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bba083651a44c28a77c7500ce57dc53
https://doi.org/10.1055/s-0038-1653314
https://doi.org/10.1055/s-0038-1653314
Autor:
V C, Menys, J A, Davies
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 50(2)
The effects of a cyclooxygenase inhibitor (indomethacin), a thromboxane synthetase inhibitor (dazoxiben), and a thromboxane antagonist (EPO45) on rabbit platelet aggregation induced by collagen were studied and compared with effects on platelet uptak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::537ded371d277169f1d69aa680d3bf43
https://pubmed.ncbi.nlm.nih.gov/6546403
https://pubmed.ncbi.nlm.nih.gov/6546403