Zobrazeno 1 - 10
of 69
pro vyhledávání: '"V. Blancuzzi"'
Autor:
David Farley, Leslie Wighton Mcquire, Karen Toscano, Noela Reel, Song Xue, James Fang, Elizabeth Quadros, Ronald L. Goldberg, J. R. Doughty, Siyuan Zhou, Robert Goldstein, Raviraj Kulathila, Joseph Somers, Gary Pastor, V. Blancuzzi, H. N. Singh, Stacey LaVoie, Robert A. Doti, Lauren G. Monovich, Kirk Clark, Tommasi Ruben A, Dennis M. Roland, John Fitt, Lijuan Zhu, Elizabeth O'Byrne, Vishwas Ganu, Jerry W. Skiles, Wen-Chung Shieh, David Thomas Parker, Theodore C. Pellas, Yumi Sakane, Andrew Wigg, Wendy D. Cornell, Richard Melton, William Macchia, Roger Aki Fujimoto
Publikováno v:
Journal of Medicinal Chemistry. 52:3523-3538
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would therefore be a novel disease modifying therapy for the treatment of a
Autor:
Ronald L. Goldberg, V. Blancuzzi, Michael R. Justice, Lijuan Zhu, Michael Paul Capparelli, Salvatore Spirito, L R Fryer, Brian J Carroll, J. R. Doughty, Erol K. Bayburt, Elizabeth O'Byrne, Robert Goldstein, Vishwas Ganu, Doug Wilson, Macpherson Lawrence J, David Thomas Parker, Richard Melton, Shou-Ih Hu
Publikováno v:
Journal of Medicinal Chemistry. 40:2525-2532
Structure-activity relationships of a lead hydroxamic acid inhibitor of recombinant human stromelysin were systematically defined by taking advantage of a concise synthesis that allowed diverse functionality to be explored at each position in a templ
Autor:
E. D. Roberts, J. Gronlund-Jacob, Elizabeth O'Byrne, G. DiPasquale, V. Blancuzzi, P. K. Paul, D. Wilson, K. Vosbeck
Publikováno v:
Experimental Biology and Medicine. 203:30-37
Cartilage pathology in rabbit knees was monitored by noninvasive magnetic resonance imaging (MRI) and evaluated using morphometric histologic measurements. Infusion of rabbit knees with the cytokine interleukin 1 induces cartilage degradation and inf
Autor:
Elizabeth O'Byrne, H. N. Singh, Gary Pastor, Susan Uziel-Fusi, Boehnlein Ernst, Theodore C. Pellas, Jianyun Yin, Joseph Quintavalla, Karl H. Kraus, V. Blancuzzi
Publikováno v:
Biomaterials. 23(1)
Several studies have reported enhanced repair of damaged cartilage following implantation of mesenchymal stem cells (MSCs) into full-thickness cartilage defects suggesting that the cells in the repair tissue were derived from the implant. However, it
Publikováno v:
Agents and Actions. 39:C183-C185
Intraperitoneal injection of cell wall fragments from L. casei (ATCC 11578) induces an acute and a chronic inflammatory arthritis of the distal joints of LEW/N female rats. Histopathological changes in four distal joints and hematologic changes were
Autor:
J. R. Doughty, V. Blancuzzi, Ronald L. Goldberg, Elizabeth O'Byrne, Vishwas Ganu, D. Wilson, Richard Melton
Publikováno v:
Agents and Actions. 34:226-228
We investigated production of plasminogen activator (PA) and cartilage degradation induced by injection of recombinant human interleukin-1 (rhIL-1 alpha) in rabbit knees. Rabbits were injected intra-articularly (i.a.) with 100 ng rhIL-1 alpha and nec
Autor:
Elizabeth O'Byrne, N. R. Hall, V. Blancuzzi, E. D. Roberts, A. S. Rubin, T. J. A. Lehman, D. Wilson
Publikováno v:
Agents and Actions. 34:239-241
A histopathological scoring system which grades drug effects on cellular infiltration, pannus formation, cartilage degradation and bone resorption in L. casei-induced polyarthritis in rats is described. Reference anti-rheumatic and anti-inflammatory
Autor:
Elizabeth O'Byrne, J. P. Simke, V. Blancuzzi, Jane Peppard, Arco Y. Jeng, D. Wilson, Mary Wong
Publikováno v:
Agents and Actions. 34:46-48
Intra-articular (i.a.) injection of recombinant human interleukin-1 alpha (rHuIL-1 alpha) in rabbit knees induced both an inflammation, as determined by increases in leukocytes in the joint fluid, and cartilage degradation, as measured by loss of pro
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 46
Autor:
R. L. Goldberg, D. Parker, L. MacPherson, V. Ganu, R. Melton, S. -I. Hu, V. Blancuzzi, D. Wilson, J. Doughty, S. Spirito, E. O'Byrne
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 44