Výsledky vyhledávání - "V. Blancuzzi"

Discovery of CGS 27023A, a Non-Peptidic, Potent, and Orally Active Stromelysin Inhibitor That Blocks Cartilage Degradation in Rabbits

Autor: Ronald L. Goldberg, V. Blancuzzi, Michael R. Justice, Lijuan Zhu, Michael Paul Capparelli, Salvatore Spirito, L R Fryer, Brian J Carroll, J. R. Doughty, Erol K. Bayburt, Elizabeth O'Byrne, Robert Goldstein, Vishwas Ganu, Doug Wilson, Macpherson Lawrence J, David Thomas Parker, Richard Melton, Shou-Ih Hu

Publikováno v: Journal of Medicinal Chemistry. 40:2525-2532

Structure-activity relationships of a lead hydroxamic acid inhibitor of recombinant human stromelysin were systematically defined by taking advantage of a concise synthesis that allowed diverse functionality to be explored at each position in a templ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3dc0e55fbdb3e0fba95712bb4532024
https://doi.org/10.1021/jm960871c

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Magnetic Resonance Imaging and Morphometric Quantitation of Cartilage Histology after Chronic Infusion of Interleukin 1 in Rabbit Knees

Autor: E. D. Roberts, J. Gronlund-Jacob, Elizabeth O'Byrne, G. DiPasquale, V. Blancuzzi, P. K. Paul, D. Wilson, K. Vosbeck

Publikováno v: Experimental Biology and Medicine. 203:30-37

Cartilage pathology in rabbit knees was monitored by noninvasive magnetic resonance imaging (MRI) and evaluated using morphometric histologic measurements. Infusion of rabbit knees with the cytokine interleukin 1 induces cartilage degradation and inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5850d4170b3d3b0eeabf3537b0b58cc
https://doi.org/10.3181/00379727-203-43569

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Fluorescently labeled mesenchymal stem cells (MSCs) maintain multilineage potential and can be detected following implantation into articular cartilage defects

Autor: Elizabeth O'Byrne, H. N. Singh, Gary Pastor, Susan Uziel-Fusi, Boehnlein Ernst, Theodore C. Pellas, Jianyun Yin, Joseph Quintavalla, Karl H. Kraus, V. Blancuzzi

Publikováno v: Biomaterials. 23(1)

Several studies have reported enhanced repair of damaged cartilage following implantation of mesenchymal stem cells (MSCs) into full-thickness cartilage defects suggesting that the cells in the repair tissue were derived from the implant. However, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2ef8eff4866c6479f5ae09e34ece8b
https://pubmed.ncbi.nlm.nih.gov/11762829

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Pathogenesis ofLactobacillus casei-induced polyarthritis in Lewis rats: 1. Time related changes in histopathological scores and hematology

Autor: V. Blancuzzi, G. DiPasquale, L R Fryer, Elizabeth O'Byrne, E. D. Roberts, D. Wilson

Publikováno v: Agents and Actions. 39:C183-C185

Intraperitoneal injection of cell wall fragments from L. casei (ATCC 11578) induces an acute and a chronic inflammatory arthritis of the distal joints of LEW/N female rats. Histopathological changes in four distal joints and hematologic changes were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da3ce26c209dc9c38eb4985e9e9f543
https://doi.org/10.1007/bf01972760

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Elevation of synovial plasminogen activator activity after injection of interleukin-1α into rabbit knee joint

Autor: J. R. Doughty, V. Blancuzzi, Ronald L. Goldberg, Elizabeth O'Byrne, Vishwas Ganu, D. Wilson, Richard Melton

Publikováno v: Agents and Actions. 34:226-228

We investigated production of plasminogen activator (PA) and cartilage degradation induced by injection of recombinant human interleukin-1 (rhIL-1 alpha) in rabbit knees. Rabbits were injected intra-articularly (i.a.) with 100 ng rhIL-1 alpha and nec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b148d6c7f70cb3f954d499a94730c9c4
https://doi.org/10.1007/bf01993287

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Lactobacillus casei-induced polyarthritis in Lewis rats: Histopathological scoring system for evaluation of anti-rheumatic drugs

Autor: Elizabeth O'Byrne, N. R. Hall, V. Blancuzzi, E. D. Roberts, A. S. Rubin, T. J. A. Lehman, D. Wilson

Publikováno v: Agents and Actions. 34:239-241

A histopathological scoring system which grades drug effects on cellular infiltration, pannus formation, cartilage degradation and bone resorption in L. casei-induced polyarthritis in rats is described. Reference anti-rheumatic and anti-inflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49177dafc3d911482777de5492877f9b
https://doi.org/10.1007/bf01993291

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Effects of indomethacin, triamcinolone, and dexamethasone on recombinant human interleukin-1-induced substance P and prostaglandin E2 levels in rabbit knee joints

Autor: Elizabeth O'Byrne, J. P. Simke, V. Blancuzzi, Jane Peppard, Arco Y. Jeng, D. Wilson, Mary Wong

Publikováno v: Agents and Actions. 34:46-48

Intra-articular (i.a.) injection of recombinant human interleukin-1 alpha (rHuIL-1 alpha) in rabbit knees induced both an inflammation, as determined by increases in leukocytes in the joint fluid, and cartilage degradation, as measured by loss of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a999436620f7edb9504846e45d0fcc
https://doi.org/10.1007/bf01993234

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