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Akademický článek

Invasive fish species in ichthioecosystems of Western Polissya of Ukraine

Autor: V. Sondak, V. Bihun, O. Volkochovets, N. Kolesnik, M. Simon

Publikováno v: Ribogospodarsʹka Nauka Ukraïni, Vol 2(56), Pp 18-33 (2021)

Purpose. To study ichthyocenoses, species composition and the current state of fish populations in water bodies of the Western Polissya of Ukraine by focusing on their changes under the effect of invasive fish species. Methodology. Ichthyological

Externí odkaz: https://doaj.org/article/abc884702b884e00b0ee2af85d52fd42

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Data from The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases

Autor: Priscilla K. Brastianos, Hiroaki Wakimoto, Daniel P. Cahill, Scott L. Carter, Maria Martinez-Lage, Anita Giobbie-Hurder, Megha Subramanian, Jianfang Ning, Gregory R. Wojtkiewicz, Stephen P. Schmidt, Tristan Penson, Matthew Lastrapes, Ivanna V. Bihun, Alexandria L. Fink, Benjamin M. Kuter, Christopher A. Alvarez-Breckenridge, Franziska M. Ippen

Purpose:Previous studies have shown that the PI3K/Akt/mTOR pathway is activated in up to 70% of breast cancer brain metastases, but there are no approved agents for affected patients. GDC-0084 is a brain penetrant, dual PI3K/mTOR inhibitor that has s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4462a59ba850ac6cd3caddecb662fc76
https://doi.org/10.1158/1078-0432.c.6527592

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Supplementary Figure 1 from The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases

Western blot analysis of p-p44/42 MAPK (Erk1/2) (Thr202/Tyr204), p-MEK1/2 (Ser217/221), p-p90RSK (Ser380), p-MSK1 (Thr581) in JIMT-1 BR-3, MDA-MB-361, MDA-MB-231 BrM2 and BS-004 cell lines treated with GDC-0084 in increasing concentrations for a tota

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc25e6af1c18a10c51316128945a202
https://doi.org/10.1158/1078-0432.22470510.v1

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Supplementary Figure 3 from The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases

Photomicrographs illustrating p-MEK1/2 (Ser221) and p-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) expression in mouse brains harboring either JIMT-1 BR-3 or MDA-MB-231 BrM2 intracranial tumors, stratified by treatment with sham or GDC-0084.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe3b839cacdc04735a7be46993e31f4
https://doi.org/10.1158/1078-0432.22470504.v1

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Supplementary Figure 2 from The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in PIK3CA-Mutant Breast Cancer Brain Metastases

GDC-0084-induced changes in cell cycle in the PIK3CA-mutant cell line MDA-MB-361 and in the PIK3CA-wildtype cell line BS-004

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a4ca0d25b0649bebbb06ee5469fa58
https://doi.org/10.1158/1078-0432.22470507.v1

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The Sukil River valley: a natural geological laboratory (case studies from the Ukrainian Carpathians)

Autor: Ihor M. Bubniak, Andrij M. Bubniak, Yuriy M. Vikhot, Solomiia Ya. Kril, Maria A. Oliinyk, Mykola V. Bihun

Publikováno v: Geological Society, London, Special Publications. 530

In this chapter we present a brief geological description of the Sukil River valley, which is located in the Ivano-Frankivsk region in the western part of Ukraine, and the interesting geological features found there. Here, different types of rocks ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c73cde5deff0cf2787048db56d2c7ff
https://doi.org/10.1144/sp530-2022-147

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PECULIARITIES OF CLINICAL AND PARACLINICAL INVESTIGATIONS OF WOMEN WITH OVARIAN ENDOMETRIOMAS IN COMBINATION WITH PELVIC INFLAMMATORY DISEASE

Autor: R. V. Bihun, I. K. Orishchak, N. I. Henyk, O. M. Ostrovska, V. D. Vorobiy, O. M. Zhukuliak

Publikováno v: World of Medicine and Biology. 18:021

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::699d2fc553f12ac28d7449c1bbee1fee
https://doi.org/10.26724/2079-8334-2022-3-81-21-25

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Secreted factors from equine mesenchymal stromal cells diminish the effects of TGF-β1 on equine dermal fibroblasts and alter the phenotype of dermal fibroblasts isolated from cutaneous fibroproliferative wounds

Autor: Ivanna V. Bihun, Rebecca M. Harman, Gerlinde R. Van de Walle

Publikováno v: Wound Repair and Regeneration. 25:234-247

The prevalence of cutaneous fibroproliferative disorders (CFPDs) is high and almost exclusively occurs in humans (keloids and hypertrophic scars) and horses (exuberant granulation tissue), making the horse a valuable translational model for studies o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6b86c01bb3f631c9acd072bd10d1bd4
https://doi.org/10.1111/wrr.12515

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Coefficient of Flow Rate of Inlet Cylindrical Nozzles with Lateral Orthogonal Inflow

Autor: I. V. Bihun, Volodymyr Cherniuk, Ja. M. Wojtowicz, V. V. Ivaniv

Publikováno v: Proceedings of CEE 2019 ISBN: 9783030270100

Cylindrical nozzles each of which has a lateral orthogonal inlet of fluid into it we recommend to apply in pressure distributive pipelines. By means of rotating these nozzles about their longitudinal axes, we can change the values of the angles \( \b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d77dedfe88b703673412994e1168380
https://doi.org/10.1007/978-3-030-27011-7_7

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