Zobrazeno 1 - 10
of 14
pro vyhledávání: '"V. Arvydas Skeberdis"'
Autor:
Monika Pankevičiūtė-Bukauskienė, Valeryia Mikalayeva, Vaidotas Žvikas, V. Arvydas Skeberdis, Sergio Bordel
Publikováno v:
Molecules, Vol 28, Iss 11, p 4535 (2023)
A pipeline for metabolomics, based on UPLC-ESI-MS, was tested on two malignant breast cancer cell lines of the sub-types ER(+), PR(+), and HER2(3+) (MCF-7 and BCC), and one non-malignant epithelial cancer cell line (MCF-10A). This allowed us to quant
Externí odkaz:
https://doaj.org/article/e994b9d1c46a4e33b7747747b48a6768
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Autor:
Kasper Thorsen, Vibeke S. Dam, Kasper Kjaer-Sorensen, Lisbeth N. Pedersen, V. Arvydas Skeberdis, Jonas Jurevičius, Rimantas Treinys, Ida M. B. S. Petersen, Morten S. Nielsen, Claus Oxvig, J. Preben Morth, Vladimir V. Matchkov, Christian Aalkjær, Henning Bundgaard, Henrik K. Jensen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Mutations in potassium and calcium channel genes have been associated with cardiac arrhythmias. Here, Jensen et al. show that an anion transporter chloride-bicarbonate exchanger AE3 is also responsible for the genetically-induced mechanism of cardiac
Externí odkaz:
https://doaj.org/article/97e6cbf2131e4127b04d04f0aede118d
Autor:
Bordel, Monika Pankevičiūtė-Bukauskienė, Valeryia Mikalayeva, Vaidotas Žvikas, V. Arvydas Skeberdis, Sergio
Publikováno v:
Molecules; Volume 28; Issue 11; Pages: 4535
A pipeline for metabolomics, based on UPLC-ESI-MS, was tested on two malignant breast cancer cell lines of the sub-types ER(+), PR(+), and HER2(3+) (MCF-7 and BCC), and one non-malignant epithelial cancer cell line (MCF-10A). This allowed us to quant
Autor:
Valeryia Mikalayeva, Vaidotas Žvikas, Sergio Bordel, V. Arvydas Skeberdis, Monika Pankevičiūtė
Publikováno v:
Biochemical and biophysical research communications. 585
Leucine, isoleucine and valine, known as branched chain amino acids (BCAAs), have been reported to be degraded by different cancer cells, and their biodegradation pathways have been suggested as anticancer targets. However, the mechanisms by which th
Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome
Autor:
Jonas Jurevičius, Morten Schak Nielsen, Claus Oxvig, J. Preben Morth, Vibeke Secher Dam, Kasper Thorsen, Henrik Jensen, Ida M. B. S. Petersen, Lisbeth Nørum Pedersen, V. Arvydas Skeberdis, Henning Bundgaard, Kasper Kjaer-Sorensen, Vladimir V. Matchkov, Christian Aalkjaer, Rimantas Treinys
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Thorsen, K, Dam, V S, Kjaer-Sorensen, K, Pedersen, L N, Skeberdis, V A, Jurevičius, J, Treinys, R, Petersen, I M B S, Nielsen, M S, Oxvig, C, Morth, J P, Matchkov, V V, Aalkjær, C, Bundgaard, H & Jensen, H K 2017, ' Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome ', Nature Communications, vol. 8, no. 1, 1696 . https://doi.org/10.1038/s41467-017-01630-0
Nature Communications
Thorsen, K, Dam, V S, Kjaer-Sorensen, K, Pedersen, L N, Skeberdis, V A, Jurevicius, J, Treinys, R, Petersen, I M B S, Nielsen, M S, Oxvig, C, Morth, J P, Matchkov, V V, Aalkjaer, C, Bundgaard, H & Jensen, H K 2017, ' Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome ', Nature Communications, vol. 8, 1696 . https://doi.org/10.1038/s41467-017-01630-0
Thorsen, K, Dam, V S, Kjaer-Sorensen, K, Pedersen, L N, Skeberdis, V A, Jurevičius, J, Treinys, R, Petersen, I M B S, Nielsen, M S, Oxvig, C, Morth, J P, Matchkov, V V, Aalkjær, C, Bundgaard, H & Jensen, H K 2017, ' Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome ', Nature Communications, vol. 8, no. 1, 1696 . https://doi.org/10.1038/s41467-017-01630-0
Nature Communications
Thorsen, K, Dam, V S, Kjaer-Sorensen, K, Pedersen, L N, Skeberdis, V A, Jurevicius, J, Treinys, R, Petersen, I M B S, Nielsen, M S, Oxvig, C, Morth, J P, Matchkov, V V, Aalkjaer, C, Bundgaard, H & Jensen, H K 2017, ' Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome ', Nature Communications, vol. 8, 1696 . https://doi.org/10.1038/s41467-017-01630-0
Patients with short QT syndrome (SQTS) may present with syncope, ventricular fibrillation or sudden cardiac death. Six SQTS susceptibility genes, encoding cation channels, explain
Mutations in potassium and calcium channel genes have been associ
Mutations in potassium and calcium channel genes have been associ
Autor:
Rimantas Treinys, Danguolė Zablockaitė, Vida Gendvilienė, V. Arvydas Skeberdis, Jonas Jurevičius
Publikováno v:
The Journal of Membrane Biology. 247:309-318
β3-Adrenergic receptor (β3-AR) is expressed in human atrial and ventricular tissues. Recently, we have demonstrated that it was involved in the activation of L-type Ca2+ current (I Ca,L) in human atrial myocytes and the force of contraction of huma
Akademický článek
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Publikováno v:
The Journal of Physiology. 551:239-252
The role of cyclic nucleotide phosphodiesterase (PDE) isoforms in the beta2-adrenergic stimulation of the L-type Ca2+ current (ICa,L) was investigated in frog ventricular myocytes using double patch-clamp and double-barrelled microperfusion technique
Publikováno v:
British Journal of Pharmacology. 121:1277-1286
1. The whole-cell patch-clamp was used for studying the effects of various beta1- and beta2-adrenoceptor agonists and antagonists on the L-type Ca current (Ica) in frog ventricular myocytes. 2. Dose-response curves for the effects of isoprenaline (no
Autor:
Rimantas, Treinys, Danguolė, Zablockaitė, Vida, Gendvilienė, Jonas, Jurevičius, V Arvydas, Skeberdis
Publikováno v:
The Journal of membrane biology. 247(4)
β3-Adrenergic receptor (β3-AR) is expressed in human atrial and ventricular tissues. Recently, we have demonstrated that it was involved in the activation of L-type Ca(2+) current (I(Ca,L)) in human atrial myocytes and the force of contraction of h