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Akademický článek

Sclerostin and Wnt Signaling in Idiopathic Juvenile Osteoporosis Using High-Resolution Confocal Microscopy for Three-Dimensional Analyses

Autor: Renata C. Pereira, Kathleen J. Noche, Barbara Gales, Zhangying Chen, Isidro B. Salusky, Lauren V. Albrecht

Publikováno v: Children, Vol 11, Iss 7, p 820 (2024)

Background: Idiopathic juvenile osteoporosis (IJO) is a rare condition characterized by low bone mass that can increase the risk of fractures in children. Treatment options for these patients are limited as the molecular mechanisms of disease initiat

Externí odkaz: https://doaj.org/article/6f705de70bcb4463bb3a7dbfed7a7613

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Akademický článek

Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

Autor: Gabriele Colozza, Yasaman Jami-Alahmadi, Alyssa Dsouza, Nydia Tejeda-Muñoz, Lauren V. Albrecht, Eric A. Sosa, James A. Wohlschlegel, Edward M. De Robertis

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

Abstract The canonical Wnt pathway serves as a hub connecting diverse cellular processes, including β-catenin signaling, differentiation, growth, protein stability, macropinocytosis, and nutrient acquisition in lysosomes. We have proposed that seque

Externí odkaz: https://doaj.org/article/70bc8e647cea4e6a97568c3d15403f70

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Akademický článek

Metabolism and Endocrine Disorders: What Wnt Wrong?

Autor: Carolina N. Franco, May M. Noe, Lauren V. Albrecht

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

A fundamental question in cell biology underlies how nutrients are regenerated to maintain and renew tissues. Physiologically, the canonical Wnt signaling is a vital pathway for cell growth, tissue remodeling, and organ formation; pathologically, Wnt

Externí odkaz: https://doaj.org/article/a285d7ab29cf4aa5a89be2cd217d6f6a

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Akademický článek

Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond

Autor: Carolina N. Franco, Laurence J. Seabrook, Steven T. Nguyen, Jack T. Leonard, Lauren V. Albrecht

Publikováno v: Metabolites, Vol 12, Iss 10, p 961 (2022)

Vitamin B micronutrients are essential regulators of one carbon metabolism that ensures human health. Vitamin B9, or folate, lies at the heart of the folate cycle and converges with the methionine cycle to complete the one carbon pathway. Additionall

Externí odkaz: https://doaj.org/article/69b68235519c4fd0a0699af5137b8562

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Akademický článek

Characterization of Primary Cilia in Osteoblasts Isolated From Patients With ADPKD and CKD

Autor: Renata C Pereira, Berenice Y Gitomer, Michel Chonchol, Peter C Harris, Kathleen J Noche, Isidro B Salusky, Lauren V Albrecht

Publikováno v: JBMR Plus, Vol 5, Iss 4, Pp n/a-n/a (2021)

ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of chronic kidney disease (CKD) and leads to a specific type of bone disease. The primary cilium is a major cellular organelle implicated in the pathophy

Externí odkaz: https://doaj.org/article/6078aacf175644adb691da261c46ddaa

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Akademický článek

Self-Consistent Parameterization of DNA Residues for the Non-Polarizable AMBER Force Fields

Autor: Amelia L. Schneider, Amanda V. Albrecht, Kenneth Huang, Markus W. Germann, Gregory M. K. Poon

Publikováno v: Life, Vol 12, Iss 5, p 666 (2022)

Fixed-charge (non-polarizable) forcefields are accurate and computationally efficient tools for modeling the molecular dynamics of nucleic acid polymers, particularly DNA, well into the µs timescale. The continued utility of these forcefields depend

Externí odkaz: https://doaj.org/article/38ffe3735aa24be0b66633341e14ab3b

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Akademický článek

GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery

Autor: Lauren V. Albrecht, Nydia Tejeda-Muñoz, Maggie H. Bui, Andrew C. Cicchetto, Daniele Di Biagio, Gabriele Colozza, Ernst Schmid, Stefano Piccolo, Heather R. Christofk, Edward M. De Robertis

Publikováno v: Cell Reports, Vol 32, Iss 4, Pp 107973- (2020)

Summary: Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the β-catenin destruction complex. We find that mutation o

Externí odkaz: https://doaj.org/article/755ba4acfcda4998a5b3697ba8f76315

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