Zobrazeno 1 - 10
of 53
pro vyhledávání: '"V. A. Tronov"'
Autor:
E. I. Nekrasova, V. A. Tronov
Publikováno v:
Biophysics. 65:460-467
Systemic administration of N-methyl-N-nitrosourea in rats resulted in the death of retinal photoreceptors followed by differentiation of retinal Muller glial cells into photoreceptor-like cells [27]. However, mammalian Muller glial cells exhibit an e
Publikováno v:
Cell and Tissue Biology. 12:468-476
Single intraperitoneal injection of methylnitrosourea (MNU) induces in mice the loss of retinal photoreceptors as a nonlinear dose response (Tronov et al. 2015). DNA repair was the putative mechanism for causing a threshold of DNA alkylation in retin
Publikováno v:
Tsitologiya. 60:440-447
Publikováno v:
Cell and Tissue Biology. 9:198-207
Exposure to a low level of stress, so-called preconditioning, has been shown to have a protective effect on the retina. Our previous studies demonstrated that there are nonlinear relationships between the doses of ionizing radiation and N-methyl-N-ni
Publikováno v:
Physics of Particles and Nuclei Letters. 12:173-183
Emerging body of data indicate protecting effect of low level of stress (preconditioning) on retina. Our previous study revealed non-linear dose-response relationship for cytotoxicity of both ionizing radiation and N-methyl-N-nitrosourea (MNU) on mou
Publikováno v:
Cell and Tissue Biology. 6:219-227
Retinopathy of animals is induced by many DNA-damaging agents. This fact shows that DNA lesions may initiate retinal degeneration. The aim of our work was to study the effects of gamma and proton irradiation and single administration of methylnitroso
Publikováno v:
Cell and Tissue Biology. 5:29-36
Melanoma is a highly aggressive tumor of melanocytes. The efficacy of different cytotoxic chemotherapy regimens does not exceed 20%. The search for markers for patient sensitivity to chemotherapy provides a rational basis for the development of cytot
Publikováno v:
Russian Journal of Genetics. 46:146-156
Melanoma is among the most aggressive malignancies. Tumors with a thickness of 4 mm can produce metastases, and the mean survival of the patients is 9 months. The review presents modern classification of the melanoma types based on cytological and mo
Publikováno v:
Russian Journal of Genetics. 44:595-600
Total repair capability is a widely used phenotypic marker of predisposition to cancer. Evaluation of this parameter implies using a challenge mutagen in an in vitro system to unmask latent genetic instability and repair insufficiency in the target c
Publikováno v:
Russian Journal of Genetics. 43:430-436
Colorectal cancer (CC) is one of two diseases, in which the link between cancer proneness and DNA repair deficiency appears to be proved. A strict relationship between mismatch repair (MMR) gene mutations, microsatellite instability (MSI) has been fo