Zobrazeno 1 - 10 of 10 pro vyhledávání: '"V. A. Farrar"'
1
Anticonvulsant Enaminones: With Emphasis on Methyl 4-[(p-Chloro­phenyi)Amino]-6-Methyi-2-0xocyclohex-3-En-1-0ate(ADD 196022)
Autor: I. O. Edafiogho, M. S. Alexander, J. A. Moore, V. A. Farrar, K. R. Scott
Publikováno v: Current Medicinal Chemistry. 1:159-175
Enaminones, enamines of B-dicarbonyl compounds have been known for many years. Their main therapeutic utility was as prodrugs for various amines, stabilizing these active compounds principally in basic media. Our laboratory discovered a series of ena
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d666df8f6842c69150d0dd7162ad9d48
https://doi.org/10.2174/092986730102220214154054
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2
Synthesis, Reactions, and Preliminary Evaluations of Enaminone Esters
Autor: V. A. Farrar, I. O. Edafiogho, Jacqueline A. Moore, Jesse M. Nicholson, Kenneth R. Scott
Publikováno v: Journal of Pharmaceutical Sciences. 83:79-84
□ The objective of this work was to design enaminone esters that would possess potential medicinal properties. The reaction between β-hydroxyketo esters and primary or secondary amines yielded secondary or tertiary enaminone esters, respectively.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a37a21249fc51a90465c1c2fa430b4a
https://doi.org/10.1002/jps.2600830119
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3
ChemInform Abstract: Cyclization Reactions Leading to β-Hydroxyketo Esters
Autor: Jacqueline A. Moore, I. O. Edafiogho, V. A. Farrar, Kenneth R. Scott, Jesse M. Nicholson
Publikováno v: ChemInform. 25
□ The purpose of the research was to synthesize β-diketo esters and to evaluate them for anticonvulsant activity. The reaction of methyl vinyl ketone with dimethyl malonate in the presence of potassium carbonate gave an uncyclized product that und
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b81cac4ea1786be7a5c12b87ab840eb4
https://doi.org/10.1002/chin.199419099
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4
ChemInform Abstract: Synthesis, Reactions, and Preliminary Evaluations of Enaminone Esters
Autor: Jesse M. Nicholson, I. O. Edafiogho, Kenneth R. Scott, V. A. Farrar, Jacqueline A. Moore
Publikováno v: ChemInform. 25
□ The objective of this work was to design enaminone esters that would possess potential medicinal properties. The reaction between β-hydroxyketo esters and primary or secondary amines yielded secondary or tertiary enaminone esters, respectively.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2eade987bb16b33c4b38979a3e8e13fa
https://doi.org/10.1002/chin.199419100
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7
Cyclization Reactions Leading to β-Hydroxyketo Esters
Autor: Jacqueline A. Moore, Jesse M. Nicholson, V. A. Farrar, Kenneth R. Scott, I. O. Edafiogho
Publikováno v: Journal of Pharmaceutical Sciences. 83:76-78
The purpose of the research was to synthesize beta-diketo esters and to evaluate them for anticonvulsant activity. The reaction of methyl vinyl ketone with dimethyl malonate in the presence of potassium carbonate gave an uncyclized product that under
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cea4a41722465a8773640b1af186a4b
https://doi.org/10.1002/jps.2600830118
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8
Development of nuclear transfer and parthenogenetic rabbit embryos activated with inositol 1,4,5-trisphosphate
Autor: S M, Mitalipov, K L, White, V R, Farrar, J, Morrey, W A, Reed
Publikováno v: Biology of reproduction. 60(4)
The present study was carried out to evaluate the effects of different activation protocols, enucleation methods, and culture media on the development of parthenogenetic and nuclear transfer (NT) rabbit embryos. Electroporation of 25 mM inositol 1,4,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::60129aeac5cd62cd2189fea20dd0d0b7
https://pubmed.ncbi.nlm.nih.gov/10084954
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9
Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations
Autor: K R, Scott, G O, Rankin, J P, Stables, M S, Alexander, I O, Edafiogho, V A, Farrar, K R, Kolen, J A, Moore, L D, Sims, A D, Tonnu
Publikováno v: Journal of medicinal chemistry. 38(20)
In a continuing evaluation of the aniline-substituted enaminones, the synthesis of additional para-substituted analogs has been made in an attempt to further quantify the electronic (sigma) and lipophilic (pi) requirements for anticonvulsant activity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d7a6727452c25df1f712fb17a3f59cc
https://pubmed.ncbi.nlm.nih.gov/7562939
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10
Synthesis and CLOGP correlation of imidooxy anticonvulsants
Autor: V A, Farrar, M, Ciechanowicz-Rutkowska, J, Grochowski, P, Serda, T, Pilati, G, Filippini, C N, Hinko, A, el-Assadi, J A, Moore, I O, Edafiogho
Publikováno v: Journal of medicinal chemistry. 36(23)
Continuing structure-activity studies on the anticonvulsant activity of analogs of N-(benzyloxy)-2-azaspiro[4.4]nonane-1,3-dione (2a), which displayed anti-electroshock seizure (MES) activity and a protective index (TD50/ED50) of4.5 are reported. An
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67fd7de4229edc5020df1b649498c378
https://pubmed.ncbi.nlm.nih.gov/8246220
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