Zobrazeno 1 - 10
of 17
pro vyhledávání: '"V. Scott Sharp"'
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 31:629-666
An HPLC chiral separation flow scheme was developed for identification of suitable enantioseparation conditions for small molecules. This flow scheme employs various chiral stationary phases (CSPs) and separation modes with the aim of improving effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c54f6e7a52991c35d12dfe465384a829
https://doi.org/10.1080/10826070701853693
https://doi.org/10.1080/10826070701853693
Autor:
Donald S. Risley, Jeffrey D. Williams, Matthew D. Belvo, Eric P. Seest, Joseph H. Kennedy, V. Scott Sharp
Publikováno v:
Chirality. 18:437-445
This study demonstrates the increased versatility of the Chiralcel OJ-H stationary phase when using various alcohol/acetonitrile mobile phases. This chiral stationary phase has traditionally been employed in the normal phase mode and more recently wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fef0124e78074d4a026743ac7bb790
https://doi.org/10.1002/chir.20269
https://doi.org/10.1002/chir.20269
Publikováno v:
Chirality. 16:153-161
Seven macrocyclic antibiotics were evaluated as chiral selectors for the enantiomeric separation of 11 dansyl amino acids using narrow-bore high-performance liquid chromatography (HPLC). The macrocyclic antibiotics were incorporated as mobile phase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba7741d68d2ae6f724957c0bb26bedc
https://doi.org/10.1002/chir.20002
https://doi.org/10.1002/chir.20002
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 26:529-543
Chiral preparative chromatography is a technology increasingly used in the pharmaceutical industry to deliver enantiomerically pure drug candidates. A strategy for rapid screening of conditions on polysaccharide chiral stationary phases (CSPs) has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9657bbb53d5c50f7df514361a8d2e6f
https://doi.org/10.1081/jlc-120017899
https://doi.org/10.1081/jlc-120017899
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 23:1019-1028
A Chirobiotic T™ column was used for the direct separation of AMPA receptor antagonist LY293558 and the undesired enantiomer LY293559 in bulk drug substance. High performance liquid chromatography (HPLC) separation of the enantiomers was optimized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89a68a1583c0e2958dddc83d940c35be
https://doi.org/10.1081/jlc-100101504
https://doi.org/10.1081/jlc-100101504
Autor:
Joseph H. Kennedy, V. Scott Sharp, Timothy Alan Shepherd, Jeffrey Alan Dodge, John L Bowers, Charles Willis Lugar
Publikováno v:
Journal of Chromatography A. 872:75-84
Chromatographic separations of new growth hormone secretagogue compounds were developed to support structure–activity relationship (SAR) studies in conjunction with lead optimization. These new compounds differed from Merck’s MK-677 by having two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4c8133fa156706e7cda9be6f1a434
https://doi.org/10.1016/s0021-9673(99)01286-8
https://doi.org/10.1016/s0021-9673(99)01286-8
Autor:
Donald S. Risley, V. Scott Sharp
Publikováno v:
Chirality. 11:75-81
The macrocyclic antibiotic LY333328 has been evaluated as a chiral selector for the enantioseparation of nine dansylated amino acids. This macrocyclic glycopeptide was used as a chiral mobile phase additive (CMPA) in conjunction with narrow bore high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c02a99a5c98569655a255a838ee21de
https://doi.org/10.1002/(sici)1520-636x(1999)11:1<75::aid-chir13>3.0.co
https://doi.org/10.1002/(sici)1520-636x(1999)11:1<75::aid-chir13>3.0.co
Autor:
Matthew D. Belvo, Michael Gregory Bell, Douglas Linn Gernert, V. Scott Sharp, Joseph H. Kennedy, Hannah Yu, Peter Stanley Borromeo, Timothy Alan Grese, Sally Ann Kelley, Gregory A. Stephenson, Mitchell I. Steinberg, Prabhakar Kondaji Jadhav, Jeffrey D. Williams, Karen M. Zimmerman, Rachel N. Richey, Stanley P. Kolis, Peter Ambrose Lander
Publikováno v:
Journal of Medicinal Chemistry. 50:6443-6445
A novel, potent series of indole analogs were recently developed as MR antagonists, culminating in 14. This compound represents the first MR antagonist in this class of molecules, exhibiting picomolar binding affinity and in vivo blood pressure lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7278bc07b6e6e72013351da2997c964
https://doi.org/10.1021/jm701186z
https://doi.org/10.1021/jm701186z
Publikováno v:
Journal of chromatography. A. 1363
Using HPLC chiral separation screening, various columns representing the polysaccharide, macrocyclic antibiotic and brush classes were assessed in multiple chromatographic modes for the separation of evacetrapib, a potential cardiovascular drug, from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6635842767fa83f76fd058ac0671fc63
https://pubmed.ncbi.nlm.nih.gov/24725472
https://pubmed.ncbi.nlm.nih.gov/24725472
Autor:
Patrick J. Jansen, Hong Zhuang, V. Scott Sharp, Andrea L. Guisbert, Michael A. Watkins, Jerry R. Draper, Thomas M. Harris, Steven W. Baertschi, W. Smith, David P. Myers, Robert M. Montgomery, Peter G. Houghton, Gregory A. Stephenson
Publikováno v:
Journal of pharmaceutical sciences. 103(9)
Mitosis inhibitor ( R )‐litronesib (LY2523355) is a 1,3,4‐thiadiazoline‐bearing phenyl and N ‐(2‐ethylamino)ethanesulfonamido‐methyl substituents on tetrahedral C5. Chiral instability has been observed at pH 6 and above with the rate of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127925706ed60a78cebee31d51a1ccf9
https://pubmed.ncbi.nlm.nih.gov/24633856
https://pubmed.ncbi.nlm.nih.gov/24633856