Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro

Autor: E. G. Zakirova, Y. V. Vyatkin, N. A. Verechshagina, V. V. Muzyka, I. O. Mazunin, K. E. Orishchenko

Publikováno v: Вавиловский журнал генетики и селекции, Vol 24, Iss 5, Pp 512-518 (2020)

It has long been known that defects in the structure of the mitochondrial genome can cause various neuromuscular and neurodegenerative diseases. Nevertheless, at present there is no effective method for treating mitochondrial diseases. The major prob

Externí odkaz: https://doaj.org/article/7777829887c74576bb8f41287488b8bb

Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro

Autor: Y V Vyatkin, Ilya O. Mazunin, E G Zakirova, V V Muzyka, N Verechshagina, Konstantin E. Orishchenko

Publikováno v: Vavilovskij Žurnal Genetiki i Selekcii, Vol 24, Iss 5, Pp 512-518 (2020)
Vavilov Journal of Genetics and Breeding

It has long been known that defects in the structure of the mitochondrial genome can cause various neuromuscular and neurodegenerative diseases. Nevertheless, at present there is no effective method for treating mitochondrial diseases. The major prob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74e28b1376031d2f2c19d6c95fdd44f
https://vavilov.elpub.ru/jour/article/view/2715

The interrelationship between BDNF and its precursor and the level of active caspase-3 in the brain regions of neonatal rats

Autor: V. V. Muzyka, A. V. Bannova, Nikolay N. Dygalo, P. N. Men’shanov

Publikováno v: Neurochemical Journal. 6:260-264

Brain-derived neurotrophic factor (mat-BDNF) promotes neuronal survival, whereas its precursor protein (pro-BDNF) induces cell death, which indicates the opposite but potentially important roles of both forms of this neurotrophin in brain development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fcb96316d444481c806a11d3587b35d
https://doi.org/10.1134/s1819712412040095

Effects of dexamethasone on the development of neonatal rats and level of active caspase-3 in brain cortex

Autor: V. V. Muzyka, P. N. Men’shanov, N. N. Dygalo

Publikováno v: Bulletin of experimental biology and medicine. 153(4)

Dexamethasone increased the levels of active caspase-3 form in the brain cortex of neonatal rats 120 h after drug administration, but did not affect the expression of this key apoptotic protease in the brain 6 or 24 h postinjection. Increased express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cafea09017ca151772560f67dafc2a
https://pubmed.ncbi.nlm.nih.gov/22977849

Porphyrin metabolism in lymphocytes of miners exposed to diesel exhaust at oil shale mine.

Autor: Muzyka V; Laboratory of Environmental Carcinogens, Institute of Experimental and Clinical Medicine, Hiiu 42, Tallinn 11619, Estonia. muzyka@ekmi.ee, Scheepers PT, Bogovski S, Lang I, Schmidt N, Ryazanov V, Veidebaum T

Publikováno v: The Science of the total environment [Sci Total Environ] 2004 Apr 25; Vol. 322 (1-3), pp. 41-50.