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Publikováno v:
Molecular Biology. 56:580-591
Publikováno v:
Molekuliarnaia biologiia. 56(6)
The key component of the revolutionary Streptococcus pyogenes CRISPR/Cas genome editing technology is the multidomain protein Cas9. However, the specificity of wild type Cas9 is not sufficiently high for editing large genomes of higher eukaryotes, wh
Publikováno v:
Molekuliarnaia biologiia. 56(4)
The ubiquitin-proteasome system is involved in the control of all essential molecular processes under normal conditions and the response of cells to stress. Rpn4p serves as a key transcriptional regulator of the proteasome in Saccharomycetes yeast an