Zobrazeno 1 - 10
of 17
pro vyhledávání: '"V V, Poroĭkov"'
[Deanol aceglumate (nooclerin): clinical/pharmacological aspects and relevance in clinical practice]
Publikováno v:
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 113(11)
Autor:
D S, Druzhilovskiĭ, D L, Filimonov, Chenzhon, Liao, Megan, Peach, Mark, Niclaus, V V, Poroĭkov
Publikováno v:
Biomeditsinskaia khimiia. 55(5)
Finding and optimization of new HIV-1 integrase inhibitors is an important task due to the drawbacks of the existing antiretroviral therapy caused by the significant adverse effects, high cost of the treatment, and emerging resistance. In this study
Publikováno v:
Biomeditsinskaia khimiia. 52(1)
A new approach for quantitative structure-activity relationships based on MNA descriptors, fuzzy gradation method and self-consistent regression has been proposed. This approach has been realized in the computer program GUSAR (General Unrestricted St
Publikováno v:
Biomeditsinskaia khimiia. 51(3)
HIV-1 integrase is the third enzyme essential for viral replication. It represents an attractive target for new anti-HIV drugs. Diketo acids represent the most prospective class of integrase inhibitors; one of them (S1360) is currently under clinical
Publikováno v:
Biomeditsinskaia khimiia. 50(2)
The G-protein coupled peptide receptors as well as their ligands, endogenous peptides, are involved in regulation of many important physiological processes in the organism and therefore represent attractive targets for pharmaceutical investigation an
Publikováno v:
Biofizika. 48(4)
A new approach to constructing the profiles of protein families is proposed, which uses only structural similarity of amino acid residues. We derived multiple alignments of protein sequences from 3D superpositions of the protein structures and constr
Autor:
L N, Drozdov-Tikhomirov, D M, Linde, V V, Poroĭkov, A A, Aleksandrov, G I, Skurida, P V, Kovalev, V Iu, Potapov
Publikováno v:
Molekuliarnaia biologiia. 37(1)
A software package was designed and used in a detailed study of the contact regions (interfaces) of a large number of protein-protein complexes using the PDB data. It appeared that for about 75% of the complexes the amino acid composition of the subu
Publikováno v:
Bioorganicheskaia khimiia. 26(5)
The wide variety of the biological effects of peptides and their high activity are the main reasons for the search for new basic drug structures among them. The most promising compounds can be selected using the PASS computer system (Prediction of Ac
Autor:
O B, Flekhter, L T, Karachurina, V V, Poroĭkov, L R, Nigmatullina, L A, Baltina, F S, Zarudiĭ, V A, Davydova, L V, Spirikhin, I P, Baĭkova, F Z, Galin, G A, Tolstikov
Publikováno v:
Bioorganicheskaia khimiia. 26(3)
Hemisuccinates, hemiphthalates, acetylsalicylates, cinnamates, and p-methoxycinnamates of lupeol, betulin, and 3-O-acetylbetulin were synthesized via interaction with corresponding acid anhydrides or acid chlorides. A number of betulin esters in posi
Publikováno v:
Voprosy meditsinskoi khimii. 44(1)
Four amino acid's complementarity hypotheses have been checked using the data on the structure of 122 protein complexes taken from protein Brookhaven Data Bank. No one of hypotheses was conformed at the analysis of the contact region structures of th