Zobrazeno 1 - 10
of 67
pro vyhledávání: '"V V, Barchukov"'
Autor:
S. A. Kryzhanovskii, I. B. Tsorin, E. O. Ionova, V. V. Barchukov, V. N. Stolyaruk, M. B. Vititnova, L. G. Kolik, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 82-93 (2023)
Background. Earlier, on the translational model of alcoholic cardiomyopathy (ACMP) developed by us in outbred white rats, which reproduces the main clinical diagnostic signs of this disease, it was shown that in rats of both sexes under conditions of
Externí odkaz:
https://doaj.org/article/0105e1608a7d4ea5a72c22416b064989
Autor:
V. V. Barchukov, V. P. Zinchenko, I. B. Tsorin, I. Yu. Teplov, V. N. Stolyaruk, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 56-67 (2023)
Introduction. Cardiovascular diseases (CVD) remain one of the leading causes of death worldwide, claiming over 17 million lives annually. This highlights the urgent need to develop innovative drugs to combat CVD. One potential target for such drugs i
Externí odkaz:
https://doaj.org/article/abacddeba6224d1298b7e2f4a400518a
Autor:
V. V. Barchukov, V. N. Stolyaruk, I. B. Tsorin, M. B. Vititnova, S. А. Kryzhanovskii, T. Yu. Vorobieva, V. E. Biryukova, G. V. Mokrov
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 20-28 (2023)
The antiarrhythmic activity of bis-alkoxyphenyltriazaalkanes 1 and bis-alkoxyphenyldiazaalkanes 2 was analyzed in a model of reperfusion arrhythmia in rats. It was found that the key requirements for the compounds activity in this model are the use o
Externí odkaz:
https://doaj.org/article/3095327cb2ce41c497cc79c5d689f697
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 14-19 (2023)
Relevance. Alcoholic cardiomyopathy (ACMP) is the leading cause of mortality in chronic disease, which is largely associated with an increased risk of developing malignant diseases of the cardiovascular disease. Search for new drugs, including those
Externí odkaz:
https://doaj.org/article/8c3f1e25ec8d45299c17ec2fff17907e
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 19-24 (2022)
The aim of the investigation was the research of the N-deacetyllappaconitine hydrochloride antiarrhythmic properties. It was found that the studied substance was effective on the cardiac arrhythmias model caused by aconitine hydrochloride, but does n
Externí odkaz:
https://doaj.org/article/06a028767ff649c8ad6e027e70082ab1
Autor:
I. B. Tsorin, V. V. Barchukov, M. B. Vititnova, A. M. Likhosherstov, G. V. Mokrov, S. A. Kryzhanovskii
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 18-22 (2021)
The investigation purpose. N1-(2,3,4-trimethoxybenzyl)-N2-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (ALM-802 compounds) cardioprotective effect has been studied in rat models of subendocardial ischemia caused by isoproterenol and dob
Externí odkaz:
https://doaj.org/article/affe1d8e2cb2471e92e89234a9ed47c6
Autor:
I. B. Tsorin, V. V. Barchukov, E. O. Ionova, V. N. Stolayruk, M. B. Vititnova, S. A. Kryzhanovskii
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 11-16 (2020)
The exprimants based on our translational model of chronic post-infarction heart failure within the use of echocardiography showed that in animals after 90 days after the reproduction of the myocardial infarction compared to the sham operated animals
Externí odkaz:
https://doaj.org/article/706075d132da46008d4b64af4b7df1fe
Autor:
G. V. Mokrov, A. M. Likhosherstov, V. V. Barchukov, V. N. Stolyaruk, I. B. Tsorin, M. B. Vititnova, S. A. Kryzhanovskiy, T. A. Gudasheva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 18-23 (2020)
New ortho-alkoxy analogs of the compound ALM-802 1a (N1-(2-methoxybenzyl)-N2-[2-((2-methoxybenzyl)amino)ethyl]ethane-1,2-diamine trihydrochloride) and 1b (N1-(2-ethoxybenzyl)-N2-[2-((2-ethoxybenzyl)amino)ethyl]ethane-1,2-diamine trihydrochloride), wh
Externí odkaz:
https://doaj.org/article/181a636c8d854101847d41fa91a907d9
Autor:
V. V. Barchukov, I. B. Tsorin, A. M. Likhosherstov, M. B. Vititnova, G. V. Mokrov, S. A. Kryzhanovskii
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 2, Pp 23-27 (2019)
Resume. Methods. Acute subendocardial myocardial ischemia in anesthetized rats (urethane 1300 mg/kg, i.p.) was caused by isoproterenol (20 |jg/kg/ min, i.v.). Endothelial dysfunction was induced, causing hyperhomocysteinemia in rats (methionine 3 g/k
Externí odkaz:
https://doaj.org/article/f172c4cdc20b447081dd40c6444d9895
Autor:
G. V. Mokrov, A. M. Likhosherstov, V. V. Barchukov, V. N. Stolyaruk, I. B. Tsorin, M. B. Vititnova, S. A. Kryzhanovskiy, T. A. Gudasheva
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 6-11 (2019)
A new compound ALM-803 (trihydrochloride N1-(3,4,5-trimethoxybenzyl)-N2-{2-[(3,4,5-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine) was synthesized as analog of ALM 802, differing from it by the position of the methoxy groups in the phenyl rings. It
Externí odkaz:
https://doaj.org/article/222c9840a8bd4d6193e1440f2299aec4