Zobrazeno 1 - 10
of 115
pro vyhledávání: '"V Tobin"'
Autor:
Susana S. Correia, Guang Liu, Sarah Jacobson, Sylvie G. Bernier, Jenny V. Tobin, Chad D. Schwartzkopf, Emily Atwater, Elisabeth Lonie, Sam Rivers, Andrew Carvalho, Peter Germano, Kim Tang, Rajesh R. Iyengar, Mark G. Currie, John R. Hadcock, Christopher J. Winrow, Juli E. Jones
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating n
Externí odkaz:
https://doaj.org/article/b9dc10997df94c7186de03737efe4dd1
Autor:
Ali R. Banijamali, Andrew E. Carvalho, James D. Wakefield, Peter Germano, Timothy C. Barden, Jenny V. Tobin, Daniel P. Zimmer, Jaime L. Masferrer, Albert T. Profy, Mark G. Currie, G. Todd Milne
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradi
Externí odkaz:
https://doaj.org/article/644e106f3d284338801984e64cb31af8
Autor:
Daniel P. Zimmer, Courtney M. Shea, Jenny V. Tobin, Boris Tchernychev, Peter Germano, Kristie Sykes, Ali R. Banijamali, Sarah Jacobson, Sylvie G. Bernier, Renee Sarno, Andrew Carvalho, Yueh-tyng Chien, Regina Graul, Emmanuel S. Buys, Juli E. Jones, James D. Wakefield, Gavrielle M. Price, Jennifer G. Chickering, G. Todd Milne, Mark G. Currie, Jaime L. Masferrer
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by the short-lived physiologi
Externí odkaz:
https://doaj.org/article/e994be112c3a40db87031271143e9556
Publikováno v:
Polymers, Vol 13, Iss 6, p 933 (2021)
Transdermal delivery of naltrexone (NTX) can be enhanced using microneedles, although micropores generated this way can reseal by 48 h in humans, which prevents further drug delivery from a formulation. Poloxamer 407 (P407) is a thermosensitive polym
Externí odkaz:
https://doaj.org/article/73d6e5a78fe04c6daf30308dffd617d2
Publikováno v:
The Journal of Laryngology & Otology. 137:323-341
ObjectiveThis study aimed to determine the efficacy of probiotic gargles compared with placebo gargles on reducing post-tonsillectomy morbidity in adults.MethodThis was a triple-blind, randomised, controlled trial and feasibility study. Thirty adults
Autor:
Nicole K. Littlejohn, Henry L. Keen, Benjamin J. Weidemann, Kristin E. Claflin, Kevin V. Tobin, Kathleen R. Markan, Sungmi Park, Meghan C. Naber, Francoise A. Gourronc, Nicole A. Pearson, Xuebo Liu, Donald A. Morgan, Aloysius J. Klingelhutz, Matthew J. Potthoff, Kamal Rahmouni, Curt D. Sigmund, Justin L. Grobe
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1548-1560 (2016)
Activation of the brain renin-angiotensin system (RAS) stimulates energy expenditure through increasing of the resting metabolic rate (RMR), and this effect requires simultaneous suppression of the circulating and/or adipose RAS. To identify the mech
Externí odkaz:
https://doaj.org/article/e7234e0f403b4ffda221e675b42b26a6
Akademický článek
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Publikováno v:
Polymers, Vol 13, Iss 933, p 933 (2021)
Polymers
Volume 13
Issue 6
Polymers
Volume 13
Issue 6
Transdermal delivery of naltrexone (NTX) can be enhanced using microneedles, although micropores generated this way can reseal by 48 h in humans, which prevents further drug delivery from a formulation. Poloxamer 407 (P407) is a thermosensitive polym
Autor:
Pratheek Manjunath, Nena A. Riccoboni, Ronald V. Tobin, Abdul Halim Abdul Rahim, James E. Bluman, Ekaterina M. Prosser, Seth W. Jackson, Andrew Kopeikin
Publikováno v:
2020 International Conference on Unmanned Aircraft Systems (ICUAS).
Within current combat environments, there is a demand for rapid and extremely precise re-supply missions. Typical combat airdrops require long periods of planning and can produce a large signature in an operating environment which relies on stealth f
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002176 (2011)
Checkpoint pathways regulate genomic integrity in part by blocking anaphase until all chromosomes have been completely replicated, repaired, and correctly aligned on the spindle. In Saccharomyces cerevisiae, DNA damage and mono-oriented or unattached
Externí odkaz:
https://doaj.org/article/bc4ac509943a4ca8923e39617b471ddc