Zobrazeno 1 - 10
of 30
pro vyhledávání: '"V T, Nachmias"'
Autor:
M. Niu, V. T. Nachmias
Publikováno v:
Cell Adhesion and Communication. 7:311-320
Loss of adherence to substrate can, by itself, induce apoptosis (anoikis) in epithelial cells, but does not do so in fibroblasts. To test the idea that adherence transmits signals that inhibit apoptosis even in fibroblasts, we took advantage of the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11bbc00b924d03d88d521a95e85897c
https://doi.org/10.3109/15419060009015002
https://doi.org/10.3109/15419060009015002
Autor:
M I Furman, Thomas D. Pollard, V T Nachmias, D Wachsstock, D Safer, Pascal J. Goldschmidt-Clermont
Publikováno v:
Molecular Biology of the Cell. 3:1015-1024
We present evidence for a new mechanism by which two major actin monomer binding proteins, thymosin beta 4 and profilin, may control the rate and the extent of actin polymerization in cells. Both proteins bind actin monomers transiently with a stoich
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffb0c1b66ee0b234c32cee90505a77a
https://doi.org/10.1091/mbc.3.9.1015
https://doi.org/10.1091/mbc.3.9.1015
Publikováno v:
Biochemistry. 31:6179-6185
Quantitative measurements of the interactions of T beta 4 with muscle actin suggest that its only physiological role is monomer sequestration. T beta 4 forms a 1:1 complex with monomeric actin under physiological salt conditions. Its Kd for actin is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121a4ec1399db3aed6c5e77ff9b5c1d3
https://doi.org/10.1021/bi00142a002
https://doi.org/10.1021/bi00142a002
Publikováno v:
Journal of Biological Chemistry. 266:4029-4032
At least 50% of the actin in resting human platelets is unpolymerized, and the bulk of this unpolymerized actin is complexed with a recently identified acidic, heat-stable 5-kDa peptide, named "Fx." Purified Fx binds stoichiometrically to muscle G-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::001f699ce9b3e4816a285b04916676f6
https://doi.org/10.1016/s0021-9258(20)64278-8
https://doi.org/10.1016/s0021-9258(20)64278-8
Publikováno v:
Cell motility and the cytoskeleton. 38(2)
In several cell types, short-term increases in the concentration of the G-actin-sequestering peptide thymosin-beta4 (Tbeta4) cause the disassembly of F-actin bundles. To determine the extent of cell adaptability to these reductions in F-actin, we ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a9a29ffa72c4d7b69c5a8ac1ebbcd0d
https://pubmed.ncbi.nlm.nih.gov/9331222
https://pubmed.ncbi.nlm.nih.gov/9331222
Publikováno v:
Cell motility and the cytoskeleton. 36(3)
Cultured human erythroleukemia (HEL) cells were used to study the genesis of polarity in single cells. HEL cells grow in suspension in culture medium, but attach and spread on fibronectin when treated with 10 nM phorbol myristate acetate. If the spre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b55a94c8600a1f919df9fe1d66bd0b18
https://pubmed.ncbi.nlm.nih.gov/9067616
https://pubmed.ncbi.nlm.nih.gov/9067616
Publikováno v:
European journal of cell biology. 61(2)
When resting human blood platelets are stimulated with thrombin, 50 to 60% of the G-actin polymerizes to F-actin within 60 seconds. The increase in F-actin is correlated with a corresponding decrease in the complex of G-actin with T beta 4. Within 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5839df1331a1c3aad6a846d32bf037e3
https://pubmed.ncbi.nlm.nih.gov/8223720
https://pubmed.ncbi.nlm.nih.gov/8223720
Publikováno v:
The Journal of biological chemistry. 266(7)
At least 50% of the actin in resting human platelets is unpolymerized, and the bulk of this unpolymerized actin is complexed with a recently identified acidic, heat-stable 5-kDa peptide, named "Fx." Purified Fx binds stoichiometrically to muscle G-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4995b0450b7cf7aa02ae839bba9afe06
https://pubmed.ncbi.nlm.nih.gov/1999398
https://pubmed.ncbi.nlm.nih.gov/1999398
Publikováno v:
Blood. 63:606-614
Recently, the contractile protein alpha-actinin was identified in normal human platelets by its antigenic cross-reaction with a monospecific antibody to purified muscle alpha-actinin. In this study, we extend that preliminary identification of platel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2885801105d2d71a2bb23d2df9d70d88
https://doi.org/10.1182/blood.v63.3.606.bloodjournal633606
https://doi.org/10.1182/blood.v63.3.606.bloodjournal633606
Autor:
P A Gonnella, V T Nachmias
Publikováno v:
The Journal of Cell Biology
Human platelets were obtained in the fully resting state by treating discoid populations with 1.5 mM tetracaine and in the activated state by treatment with 2 microM A-23187. After gel filtration or washing, respectively, platelet suspensions were ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b094148c807ba5ce7c06edba56b6c9b9
https://doi.org/10.1083/jcb.89.1.146
https://doi.org/10.1083/jcb.89.1.146