Evolved histone tail regulates 53BP1 recruitment at damaged chromatin

Autor: Jessica L. Kelliher, Melissa L. Folkerts, Kaiyuan V. Shen, Wan Song, Kyle Tengler, Clara M. Stiefel, Seong-Ok Lee, Eloise Dray, Weixing Zhao, Brian Koss, Nicholas R. Pannunzio, Justin W. Leung

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract The master DNA damage repair histone protein, H2AX, is essential for orchestrating the recruitment of downstream mediator and effector proteins at damaged chromatin. The phosphorylation of H2AX at S139, γH2AX, is well-studied for its DNA re

Externí odkaz: https://doaj.org/article/f40958dd8a9b496c9a1c7b226404941a

Cardiac Manifestations of Lyme Disease

Autor: Richard V, Shen, Carol A, McCarthy

Publikováno v: Infectious Disease Clinics of North America. 36:553-561

Lyme carditis is an uncommon manifestation of Lyme disease. Most cases present with heart block of varying degrees, but the spectrum of disease includes other transient arrhythmias and structural manifestations, such as myopericarditis or cardiomyopa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e79f7416e263d1c059ca88a73e4d79
https://doi.org/10.1016/j.idc.2022.03.001

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Lyme Carditis in Hospitalized Children and Adults, a Case Series

Autor: Carol A. McCarthy, Richard V Shen, Robert P. Smith

Publikováno v: Open Forum Infectious Diseases

Background Lyme carditis is an uncommon manifestation of Lyme disease. This report compares Lyme carditis presentation, management, and outcomes in pediatric and adult populations. Methods Charts of pediatric and adult patients with heart block (PR i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb7c870e7e92d28af6d72380ec90c6b
http://europepmc.org/articles/PMC8266570

Bedaquiline for multidrug-resistant tuberculosis and QTc prolongation in California

Autor: Shereen Katrak, Leslie Henry, Richard V Shen, Phil Lowenthal, Pennan M. Barry, Lisa True

Publikováno v: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, Vol 23, Iss, Pp 100216-(2021)

Background: Bedaquiline (BDQ) is recommended for the treatment of multidrug-resistant tuberculosis (MDR TB), however, it has the potential to prolong QTc interval. We assessed the frequency and severity of QTc prolongation in patients receiving BDQ i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83bf4fd7f212e3d6834fbf85d212039a
https://doi.org/10.1016/j.jctube.2021.100216