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Akademický článek

GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging

Autor: Premranjan Kumar, Ob W. Osahon, Rajagopal V. Sekhar

Publikováno v: Antioxidants, Vol 12, Iss 5, p 1042 (2023)

Cognitive decline frequently occurs with increasing age, but mechanisms contributing to age-associated cognitive decline (ACD) are not well understood and solutions are lacking. Understanding and reversing mechanisms contributing to ACD are important

Externí odkaz: https://doaj.org/article/47a92a2a55f149c7ba6fe1743ed569df

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Akademický článek

Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

Autor: Premranjan Kumar, Chun Liu, Jean W. Hsu, Shaji Chacko, Charles Minard, Farook Jahoor, Rajagopal V. Sekhar

Publikováno v: Clinical and Translational Medicine, Vol 11, Iss 3, Pp n/a-n/a (2021)

Abstract Background Oxidative stress (OxS) and mitochondrial dysfunction are implicated as causative factors for aging. Older adults (OAs) have an increased prevalence of elevated OxS, impaired mitochondrial fuel‐oxidation (MFO), elevated inflammat

Externí odkaz: https://doaj.org/article/c0f273d8e34c47f1be8231c38abb59db

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Akademický článek

GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study

Autor: Rajagopal V. Sekhar

Publikováno v: Antioxidants, Vol 11, Iss 1, p 154 (2022)

Patients with type 2 diabetes (T2D) are known to have mitochondrial dysfunction and increased insulin resistance (IR), but the underlying mechanisms are not well understood. We reported previously that (a) adequacy of the antioxidant glutathione (GSH

Externí odkaz: https://doaj.org/article/1b40ef204a964496a620fcecc449f362

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Akademický článek

Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation

Autor: Premranjan Kumar, Ob Osahon, David B. Vides, Nicola Hanania, Charles G. Minard, Rajagopal V. Sekhar

Publikováno v: Antioxidants, Vol 11, Iss 1, p 50 (2021)

Humanity is battling a respiratory pandemic pneumonia named COVID-19 which has resulted in millions of hospitalizations and deaths. COVID-19 exacerbations occur in waves that continually challenge healthcare systems globally. Therefore, there is an u

Externí odkaz: https://doaj.org/article/252b2622c0704a5f919943741438ca52

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Influence of different storage temperatures and packing material in extending shelf life and quality attributes of palmyrah (Borassus flabellifer L.) neera

Autor: M. Chandra Surya Rao, D.V. Swami, P. Ashok, D.R. Salomi Suneetha, R.V. Sujatha, V. Sekhar

Publikováno v: Journal of Plantation Crops. :85-93

Palmyrah neera (inflorescence sap) is susceptible to natural fermentation at ambient temperature within a few hours of extraction due to enzymatic and microbial activity. Once fermented, neera becomes toddy which is unsuitable as a health drink or as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8eed4be7f58657b7d1a9b4fea93806fe
https://doi.org/10.25081/jpc.2022.v50.i2.7982

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Effect of high‐flow nasal oxygen on hypoxaemia during procedural sedation: a systematic review and meta‐analysis

Autor: V. Thiruvenkatarajan, V. Sekhar, D. T. Wong, J. Currie, R. Van Wijk, G. L. Ludbrook

Publikováno v: Anaesthesia. 78:81-92

We conducted a systematic review to evaluate the effect of high-flow nasal oxygen and conventional oxygen therapy during procedural sedation amongst adults and children. We searched MEDLINE, EMBASE and CINAHL for randomised controlled trials that rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c856d18bd8d3495caf3174006a382fc
https://doi.org/10.1111/anae.15845

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Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial

Autor: Premranjan Kumar, Chun Liu, James Suliburk, Jean W Hsu, Raja Muthupillai, Farook Jahoor, Charles G Minard, George E Taffet, Rajagopal V Sekhar

Publikováno v: The Journals of Gerontology: Series A. 78:75-89

Background Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f629d89ecb82dfad5abc97130b2867
https://doi.org/10.1093/gerona/glac135

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Akademický článek

Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial

Autor: Premranjan Kumar, Chun Liu, James W. Suliburk, Charles G. Minard, Raja Muthupillai, Shaji Chacko, Jean W. Hsu, Farook Jahoor, Rajagopal V. Sekhar

Publikováno v: Biomedicines, Vol 8, Iss 10, p 390 (2020)

Background: Patients with HIV (PWH) develop geriatric comorbidities, including functional and cognitive decline at a younger age. However, contributing mechanisms are unclear and interventions are lacking. We hypothesized that deficiency of the antio

Externí odkaz: https://doaj.org/article/27516905e0c64d6fb9a2f67c97be8419

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