Výsledky vyhledávání - "V S, Goldmacher"

Cell Death Suppressors Encoded by Cytomegalovirus

Autor: V. S. Goldmacher

Publikováno v: Viruses and Apoptosis ISBN: 9783540742630

Apoptosis of virally infected cells is a host defense mechanism designed to arrest viral replication by eliminating infected cells (O’Brien 1998). Apoptosis induced by virus infection can be triggered intrinsically by initiating an apoptotic pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1aa40f017bb8be2ca3572789e9271948
https://doi.org/10.1007/978-3-540-74264-7_1

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Folate-maytansinoids: target-selective drugs of low molecular weight

Autor: C A, Ladino, R V, Chari, L A, Bourret, N L, Kedersha, V S, Goldmacher

Publikováno v: International journal of cancer. 73(6)

Folate receptor is over-expressed in a variety of carcinomas. To design a cytotoxic drug that would selectively target these carcinomas, we synthesized folate-maytansinoids. These drugs showed high affinity toward folate receptor, appeared to enter c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68c0382c1a9f24b13843b95ea1cbe188
https://pubmed.ncbi.nlm.nih.gov/9399666

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Conjugation of blocked ricin to an anti-CD19 monoclonal antibody increases antibody-induced cell calcium mobilization and CD19 internalization

Autor: A C, Goulet, V S, Goldmacher, J M, Lambert, C, Baron, D C, Roy, E, Kouassi

Publikováno v: Blood. 90(6)

CD19 (B4) is a signal transduction molecule restricted to the B-cell lineage and the target of the immunotoxin anti-B4-blocked ricin (anti-B4-bR), which is composed of the monoclonal antibody (MoAb) anti-B4 and the modified plant toxin blocked ricin.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::656c714446d2dac09c99d37e813d92cf
https://pubmed.ncbi.nlm.nih.gov/9310487

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p53 status affects the rate of the onset but not the overall extent of doxorubicin-induced cell death in rat-1 fibroblasts constitutively expressing c-Myc

Autor: J W, Han, C A, Dionne, N L, Kedersha, V S, Goldmacher

Publikováno v: Cancer research. 57(1)

To better understand the effects of p53 on the process of DNA damage-induced cell death, we examined the influence of p53 status on the rate of the onset and the overall extent of cell death induced by doxorubicin. We performed this study with Rat-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4c3414a8ac0e4c66e84273fa698d2e5f
https://pubmed.ncbi.nlm.nih.gov/8988061

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Induction of apoptosis by tamoxifen-activation of a p53-estrogen receptor fusion protein expressed in E1A and T24 H-ras transformed p53-/- mouse embryo fibroblasts

Autor: C A, Vater, L M, Bartle, C A, Dionne, T D, Littlewood, V S, Goldmacher

Publikováno v: Oncogene. 13(4)

A fusion gene consisting of wild-type p53 linked to a modified ligand binding domain of the murine estrogen receptor has been constructed and should be a useful tool for studying controlled activation of wild-type p53 function in a variety of experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d6e924ff15314aa3be584419baa5f4c2
https://pubmed.ncbi.nlm.nih.gov/8761295

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Anti-B4-blocked ricin synergizes with doxorubicin and etoposide on multidrug-resistant and drug-sensitive tumors

Autor: R, O'Connor, C, Liu, C A, Ferris, B C, Guild, B A, Teicher, C, Corvi, Y, Liu, R J, Arceci, V S, Goldmacher, J M, Lambert, W A, Blättler

Publikováno v: Blood. 86(11)

Anti-B4-blocked ricin (anti-B4-bR) is an immunotoxin directed against CD19-positive cells that is currently being tested in several B-cell leukemia/lymphoma clinical trials. To explore the possibility of using anti-B4-bR in combination with chemother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88b62e39f5fbed0870b82449a173f48a
https://pubmed.ncbi.nlm.nih.gov/7492789

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Enhancement of the selectivity and antitumor efficacy of a CC-1065 analogue through immunoconjugate formation

Autor: R V, Chari, K A, Jackel, L A, Bourret, S M, Derr, B M, Tadayoni, K M, Mattocks, S A, Shah, C, Liu, W A, Blättler, V S, Goldmacher

Publikováno v: Cancer research. 55(18)

Bis-indolyl-(seco)-1,2,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e compounds are synthetic analogues of CC-1065 that are highly cytotoxic toward a broad spectrum of tumor cell lines. One of these compounds, called DC1, was conjugated to antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::49e7c87eb0ca3c6501d90e3e1d783b97
https://pubmed.ncbi.nlm.nih.gov/7545085

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Anti-CD38-blocked ricin: an immunotoxin for the treatment of multiple myeloma

Autor: V S, Goldmacher, L A, Bourret, B A, Levine, R A, Rasmussen, M, Pourshadi, J M, Lambert, K C, Anderson

Publikováno v: Blood. 84(9)

We report the development of a potent anti-CD38 immunotoxin capable of killing human myeloma and lymphoma cell lines. The immunotoxin is composed of an anti-CD38 antibody HB7 conjugated to a chemically modified ricin molecule wherein the binding site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3942e1871cce618c9151283fb5acd449
https://pubmed.ncbi.nlm.nih.gov/7718903

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