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Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis

Autor: M M, Griffiths, J, Wang, B, Joe, S, Dracheva, Y, Kawahito, J S, Shepard, V R, Reese, S, McCall-Vining, A, Hashiramoto, G W, Cannon, E F, Remmers, R L, Wilder

Publikováno v: Arthritis and rheumatism. 43(6)

Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats.Genome scans covering ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::325e6d0691264c1b70f80103c30cf7ff
https://pubmed.ncbi.nlm.nih.gov/10857786

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Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats

Autor: P S, Gulko, Y, Kawahito, E F, Remmers, V R, Reese, J, Wang, S V, Dracheva, L, Ge, R E, Longman, J S, Shepard, G W, Cannon, A D, Sawitzke, R L, Wilder, M M, Griffiths

Publikováno v: Arthritis and rheumatism. 41(12)

To identify novel non-major histocompatibility complex (non-MHC) genetic loci controlling the severity of homologous rat type II collagen-induced arthritis (CIA).We conducted a genome-wide scan to identify CIA regulatory quantitative trait loci (QTL)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6cfeff3569b145af00ffc9ea0abef9ac
https://pubmed.ncbi.nlm.nih.gov/9870869

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Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases

Autor: Y, Kawahito, G W, Cannon, P S, Gulko, E F, Remmers, R E, Longman, V R, Reese, J, Wang, M M, Griffiths, R L, Wilder

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(8)

Adjuvant-induced arthritis (AIA) in rats is a widely used autoimmune experimental model with many features similar to rheumatoid arthritis (RA). To identify potential genetic regulatory mechanisms in RA, we conducted genome-wide linkage analysis in F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50b1b2d1f03f67b6130b034dc8f5d21f
https://pubmed.ncbi.nlm.nih.gov/9780220

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