Výsledky vyhledávání - "V R, Lingappa"

Akademický článek

Asymmetric distribution of pause transfer sequences in apolipoprotein B-100

Autor: M H Kivlen, C A Dorsey, V R Lingappa, R S Hegde

Publikováno v: Journal of Lipid Research, Vol 38, Iss 6, Pp 1149-1162 (1997)

Lipoprotein assembly requires a complex and regulated set of events that includes apolipoprotein B (apoB) translocation across the endoplasmic reticulum (ER) membrane, folding, and association with lipids. Unlike simple secretory proteins which are c

Externí odkaz: https://doaj.org/article/d17855585c1548a994457436fb7b85f4

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A trabecular meshwork glucocorticoid response (TIGR) gene mutation affects translocational processing

Autor: C C, Zimmerman, V R, Lingappa, J E, Richards, F W, Rozsa, P R, Lichter, J R, Polansky

Publikováno v: Molecular vision. 5

To examine possible effects of the E323K mutation in the trabecular meshwork glucocorticoid response (TIGR) gene (also known as myocilin [MYOC]), using assays of translocational processing through the endoplasmic reticulum (ER). The E323K mutation wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e131121b7ffbda16c3a88df69c38d36
https://pubmed.ncbi.nlm.nih.gov/10459044

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California's Proposition 186: lessons from a single-payer health care reform ballot initiative campaign

Autor: K, Farey, V R, Lingappa

Publikováno v: Journal of public health policy. 17(2)

Proposition 186 was an initiative on the November 1994 California ballot which proposed to establish a state single-payer health care program. Although Prop 186 was overwhelmingly defeated in the November 1994 election (73% No, 27% Yes), it accomplis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::472b8222f92ea8253310997e46abfe54
https://pubmed.ncbi.nlm.nih.gov/8764388

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Complex environment of nascent polypeptide chains

Autor: W J, Hansen, V R, Lingappa, W J, Welch

Publikováno v: The Journal of biological chemistry. 269(43)

Nascent polypeptides enter into high molecular weight complexes with other proteins during chain elongation in vitro and in vivo. The nature of these complexes was investigated using an in vitro translation system programmed with a single mRNA lackin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3ca6a5981d5b0d52002f7aff636923f
https://pubmed.ncbi.nlm.nih.gov/7929390

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Determinants of carboxyl-terminal domain translocation during prion protein biogenesis

Autor: K A, De Fea, D H, Nakahara, M C, Calayag, C S, Yost, L F, Mirels, S B, Prusiner, V R, Lingappa

Publikováno v: The Journal of biological chemistry. 269(24)

The prion protein (PrP) displays some unusual features in its biogenesis. In cell-free systems it can be synthesized as either an integral transmembrane protein spanning the membrane twice, with both amino and carboxyl domains in the lumen of the end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7913d6ff4f0c8d2c3f0956e5a31f3d9
https://pubmed.ncbi.nlm.nih.gov/7911469

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Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1)

Autor: W R, Skach, V R, Lingappa

Publikováno v: Cancer research. 54(12)

Understanding how the multidrug resistance phenotype is manifest in human cancer cells will require insight into the mechanism of assembly, transmembrane topology, and intracellular trafficking of human P-glycoprotein (MDR1). Previously, we showed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc5b17097e231f690ee953bc15108bf4
https://pubmed.ncbi.nlm.nih.gov/7911395

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Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences

Autor: W R, Skach, V R, Lingappa

Publikováno v: The Journal of biological chemistry. 268(31)

Transmembrane topology of polytopic integral membrane proteins is established during protein synthesis at the endoplasmic reticulum membrane. For some polytopic proteins, sequential and independent signal, stop transfer, and/or signal anchor sequence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77d191e879cbe1b3c9eecb1257567f23
https://pubmed.ncbi.nlm.nih.gov/7901209

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Analysis of a pause transfer sequence from apolipoprotein B

Autor: S L, Chuck, V R, Lingappa

Publikováno v: The Journal of biological chemistry. 268(30)

In contrast to typical secretory proteins, apolipoprotein B pauses at distinct points along the nascent chain during its translocation into the lumen of the endoplasmic reticulum. Specific pause transfer sequences mediate such discrete pauses in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57a3592e14d15871b2553c946f095271
https://pubmed.ncbi.nlm.nih.gov/8226789

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Evidence for an alternate model of human P-glycoprotein structure and biogenesis

Autor: W R, Skach, M C, Calayag, V R, Lingappa

Publikováno v: The Journal of biological chemistry. 268(10)

We have studied the transmembrane topology of human P-glycoprotein (MDR1) using protein chimeras in Xenopus oocytes and full-length native protein in a cell-free translation system. We find both in vivo and in vitro, that the peptide region between p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09fee4ed5025501eb962824bf7c894c9
https://pubmed.ncbi.nlm.nih.gov/8096508

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