Zobrazeno 1 - 10
of 19
pro vyhledávání: '"V R, Kelley"'
Publikováno v:
The Journal of Immunology. 157:427-432
The lpr mutation on the MRL background accelerates autoimmune nephritis in which macrophage (M phi) accumulation is prominent. Renal disease is absent in other strains with lpr. TNF-alpha and CSF-1 are increased in the kidney of MRL-lpr mice with los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d0919d1bcef5347c5cab9172541b6bc
https://doi.org/10.4049/jimmunol.157.1.427
https://doi.org/10.4049/jimmunol.157.1.427
Publikováno v:
The Journal of Immunology. 157:433-440
Mice with the MRL background have a genetic propensity for autoimmune lupus nephritis. The lpr mutation on the MRL, but not the C3H background, induces rapid and fatal renal injury in which macrophages (M phi) are prominent. We previously established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e737a34795adeab624cb674d747c5ad
https://doi.org/10.4049/jimmunol.157.1.433
https://doi.org/10.4049/jimmunol.157.1.433
Publikováno v:
The Journal of Immunology. 156:4961-4968
The lpr mutation, a disruption of the fas gene, induces spontaneous autoimmunity characterized by high titers of autoantibodies, lymphadenopathy, autoreactive T cells, and early mortality. The mechanism of autoimmunity, however, remains unknown. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf6525863b3c83ec87f7eedc9868990
https://doi.org/10.4049/jimmunol.156.12.4961
https://doi.org/10.4049/jimmunol.156.12.4961
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(12)
IL-12 is secreted by kidney tubular epithelial cells in autoimmune MRL-Fas(lpr) mice before renal injury and increases with advancing disease. Because IL-12 is a potent inducer of IFN-gamma, the purpose of this study was to determine whether local pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73980aa9415b5934b85c7e2ded17b8fd
https://pubmed.ncbi.nlm.nih.gov/10586090
https://pubmed.ncbi.nlm.nih.gov/10586090
Autor:
M H, Foster, V R, Kelley
Publikováno v:
Seminars in nephrology. 19(2)
Immune-mediated nephritis is a common complication of systemic lupus erythematosus (SLE). It is now clear that multiple and independent mechanisms contribute to disease onset and pathogenesis, which may explain the remarkable phenotypic and histopath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::680076c600b39588d9d5a139ca98d462
https://pubmed.ncbi.nlm.nih.gov/10192250
https://pubmed.ncbi.nlm.nih.gov/10192250
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(1)
CSF-1 and TNF-alpha in the kidney of MRL-Fas(lpr) mice are proximal events that precede and promote autoimmune lupus nephritis, while apoptosis of renal parenchymal cells is a feature of advanced human lupus nephritis. In the MRL-Fas(lpr) kidney, inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::434749d82a465323cda2ce01b6b84dda
https://pubmed.ncbi.nlm.nih.gov/9647261
https://pubmed.ncbi.nlm.nih.gov/9647261
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(8)
IFN-gamma is capable of enhancing and limiting inflammation. Therefore, an increase in IFN-gamma in autoimmune MRL-Fas(lpr) mice could exacerbate or thwart renal injury. We have established a retroviral gene transfer approach to incite interstitial n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a51b8c811749c3ebf2e055b583df937
https://pubmed.ncbi.nlm.nih.gov/9558118
https://pubmed.ncbi.nlm.nih.gov/9558118
Autor:
V R, Kelley, K J, Moore
Publikováno v:
Experimental nephrology. 5(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1185467783dfc6c5cb6fd84cff2fa428
https://pubmed.ncbi.nlm.nih.gov/9108997
https://pubmed.ncbi.nlm.nih.gov/9108997
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(1)
Mice with the MRL background have a genetic propensity for autoimmune lupus nephritis. The lpr mutation on the MRL, but not the C3H background, induces rapid and fatal renal injury in which macrophages (M phi) are prominent. We previously established
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8668ee40402d1ad0a93f9eb894f0bfb6
https://pubmed.ncbi.nlm.nih.gov/8683149
https://pubmed.ncbi.nlm.nih.gov/8683149
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(1)
The lpr mutation on the MRL background accelerates autoimmune nephritis in which macrophage (M phi) accumulation is prominent. Renal disease is absent in other strains with lpr. TNF-alpha and CSF-1 are increased in the kidney of MRL-lpr mice with los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d40cbbce949bfe24b5803f5918623b5
https://pubmed.ncbi.nlm.nih.gov/8683148
https://pubmed.ncbi.nlm.nih.gov/8683148