Zobrazeno 1 - 10
of 32
pro vyhledávání: '"V P, Perry"'
Autor:
Marta Vicente-Rodríguez, Renzo Mancuso, Alba Peris-Yague, Camilla Simmons, NIMA Consortium, Diego Gómez-Nicola, V. Hugh Perry, Federico Turkheimer, Simon Lovestone, Christine A. Parker, Diana Cash
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or a secondary outcome. For that reason, either as diagnostic tools or to monitor progression and/or pharmacological interventions, th
Externí odkaz:
https://doaj.org/article/b170cf7515074d439babacd3d3763def
Autor:
Sarmi Sri, Chrysia-Maria Pegasiou, Chantal Abbigail Cave, Katie Hough, Natalie Wood, Diego Gomez-Nicola, Katrin Deinhardt, David Bannerman, V. Hugh Perry, Mariana Vargas-Caballero
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-20 (2019)
Abstract The synaptic changes underlying the onset of cognitive impairment in Alzheimer’s disease (AD) are poorly understood. In contrast to the well documented inhibition of long-term potentiation (LTP) in CA3-CA1 synapses by acute Aβ application
Externí odkaz:
https://doaj.org/article/130ab83bdb804962b7dac2c92b0f9be8
Autor:
Juliane Obst, Emilie Simon, Maria Martin-Estebane, Elena Pipi, Liana M. Barkwill, Ivette Gonzalez-Rivera, Fergus Buchanan, Alan R. Prescott, Dorte Faust, Simon Fox, Janet Brownlees, Debra Taylor, V. Hugh Perry, Hugh Nuthall, Peter J. Atkinson, Eric Karran, Carol Routledge, Diego Gomez-Nicola
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The proliferation and activation of microglia, the resident macrophages in the brain, is a hallmark of many neurodegenerative diseases such as Alzheimer's disease (AD) and prion disease. Colony stimulating factor 1 receptor (CSF1R) is critically invo
Externí odkaz:
https://doaj.org/article/6be8eff32df0428cae95ce824dd7f941
Autor:
Katharine Askew, Kaizhen Li, Adrian Olmos-Alonso, Fernando Garcia-Moreno, Yajie Liang, Philippa Richardson, Tom Tipton, Mark A. Chapman, Kristoffer Riecken, Sol Beccari, Amanda Sierra, Zoltán Molnár, Mark S. Cragg, Olga Garaschuk, V. Hugh Perry, Diego Gomez-Nicola
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 391-405 (2017)
Summary: Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial p
Externí odkaz:
https://doaj.org/article/028b5c11281a46cabd72822e276b57e1
Autor:
James Alibhai, Richard A Blanco, Marcelo A Barria, Pedro Piccardo, Byron Caughey, V Hugh Perry, Tom C Freeman, Jean C Manson
Publikováno v:
PLoS Biology, Vol 14, Iss 11, p e1002579 (2016)
Protein misfolding is common across many neurodegenerative diseases, with misfolded proteins acting as seeds for "prion-like" conversion of normally folded protein to abnormal conformations. A central hypothesis is that misfolded protein accumulation
Externí odkaz:
https://doaj.org/article/fa81a882e71a410881ef44e8fa45620f
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 1, Pp 63-74 (2009)
Intrahippocampal injection of the murine modified scrapie (ME7) induces a model of prion disease in vivo. Animals inoculated with ME7 brain homogenate were compared to controls at 8, 12 and 21 weeks. The data show that the accumulation of misfolded p
Externí odkaz:
https://doaj.org/article/b2f28733b024490d850c2be66da5c15e
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 1, Pp 19-29 (2008)
Axon loss in the CNS is characteristic of many neurodegenerative diseases but the mechanisms of axon degeneration are poorly understood. In particular, we know little of the inflammatory response triggered by CNS axon degeneration with comparison to
Externí odkaz:
https://doaj.org/article/7fd638a8361941059f3ac1e2fea5ce21
Autor:
Mark Ide, Marina Harris, Annette Stevens, Rebecca Sussams, Viv Hopkins, David Culliford, James Fuller, Paul Ibbett, Rachel Raybould, Rhodri Thomas, Ursula Puenter, Jessica Teeling, V Hugh Perry, Clive Holmes
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151081 (2016)
Periodontitis is common in the elderly and may become more common in Alzheimer's disease because of a reduced ability to take care of oral hygiene as the disease progresses. Elevated antibodies to periodontal bacteria are associated with an increased
Externí odkaz:
https://doaj.org/article/1af79cc0eafd47ada84f72a5389b193d
Autor:
Kerry A. Broom, Daniel C. Anthony, John P. Lowe, Julian L. Griffin, Helen Scott, Andrew M. Blamire, Peter Styles, V. Hugh Perry, Nicola R. Sibson
Publikováno v:
Neurobiology of Disease, Vol 26, Iss 3, Pp 707-717 (2007)
Prion diseases are fatal chronic neurodegenerative diseases. Previous qualitative magnetic resonance imaging (MRI) and spectroscopy (MRS) studies report conflicting results in the symptomatic stages of the disease, but little work has been carried ou
Externí odkaz:
https://doaj.org/article/64e0f0851a2945a8b00da552e3f130a5
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 3, Pp 638-650 (2006)
The ME7 model of murine prion disease shows an atypical inflammatory response characterized by morphologically activated microglia and an anti-inflammatory cytokine profile with a marked expression of TGFβ1. The investigation of the role of TGFβ1 d
Externí odkaz:
https://doaj.org/article/9086c18ef42b4e899da4443417d2d760