Zobrazeno 1 - 10 of 48 pro vyhledávání: '"V N, Sorokoumov"'
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Akademický článek
Influence of metformin therapy and treatment with an allosteric luteinizing hormone agonist and chorionic gonadotropin on spermatogenesis in male rats with obesity
Autor: K. V. Derkach, I. Yu. Morina, L. V. Bayunova, A. A. Bakhtuykov, E. A. Didenko, V. N. Sorokoumov, I. V. Romanova, A. O. Shpakov
Publikováno v: Ожирение и метаболизм, Vol 20, Iss 3, Pp 217-226 (2023)
BACKGROUND: In men, obesity is accompanied by a complex of metabolic and hormonal disorders, which leads to androgen deficiency and impaired spermatogenesis. Antidiabetic drugs, including metformin (MF), and luteinizing hormone receptor (LHR) agonist
Externí odkaz: https://doaj.org/article/4a0244e4053045088cf961accc79a4c8
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5
Application of an Allosteric Agonist of the Luteinizing Hormone Receptor for Reducing the Effective Dose of Gonadotropin in the Treatment of Androgen Deficiency in Rats with Type 1 Diabetes
Autor: A. A. Bakhtyukov, K. V. Derkach, V. N. Sorokoumov, A. O. Shpakov
Publikováno v: Journal Biomed. 18:72-78
In type 1 diabetes mellitus, the impaired testosterone synthesis in the testes leads to androgen deficiency. The long-term application of high gonadotropin doses for its correction decreases the sensitivity of luteinizing hormone/human chorionic gona
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c390a9d6bc2ca9e8f41879d420604348
https://doi.org/10.33647/2074-5982-18-3-72-78
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9
The Effect of Low-Molecular-Weight Allosteric Agonist of Luteinizing Hormone Receptor on Functional State of the Testes in Aging and Diabetic Rats
Autor: I. V. Romanova, Dmitry Dar'in, Andrey A. Bakhtyukov, I. Yu. Morina, A. O. Shpakov, V. N. Sorokoumov, Kira V. Derkach
Publikováno v: Bulletin of Experimental Biology and Medicine. 171:81-86
Human chorionic gonadotropin that is widely used for improving spermatogenesis. The effect of chorionic gonadotropin is mediated through luteinizing hormone receptor. Treatment with gonadotropin is associated with undesirable effects due to hyperacti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bba250df7c515acec96fbd27debd499
https://doi.org/10.1007/s10517-021-05177-5
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10
Effect of Low-Molecular-Weight Allosteric Agonists of the Luteinizing Hormone Receptor on Its Expression and Distribution in Rat Testes
Autor: A. O. Shpakov, A. A. Bakhtyukov, A. A. Perminova, A. I. Govdi, I. V. Romanova, T. V. Sokolova, I. Yu. Morina, V. N. Sorokoumov, Kira V. Derkach
Publikováno v: Journal of Evolutionary Biochemistry and Physiology. 57:208-220
Human chorionic gonadotropin (hCG) and luteinizing hormone (LH) regulate testicular steroidogenesis by interacting with the orthosteric site located in the extracellular domain of the LH receptor (LHR). The use of hCG and LH in medicine is fraught wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77da1370d203805f050f1b398ec28724
https://doi.org/10.1134/s0022093021020034
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