Zobrazeno 1 - 10
of 492
pro vyhledávání: '"V Michael, Holers"'
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/9ef6116075824e6a80b93a257a4b1046
Autor:
Eddie A. James, V. Michael Holers, Radhika Iyer, E. Barton Prideaux, Navin L. Rao, Cliff Rims, Virginia S. Muir, Sylvia E. Posso, Michelle S. Bloom, Amin Zia, Serra E. Elliott, Julia Z. Adamska, Rizi Ai, R. Camille Brewer, Jennifer A. Seifert, LauraKay Moss, Saman Barzideh, M. Kristen Demoruelle, Christopher C. Striebich, Yuko Okamoto, Enkhtsogt Sainbayar, Alexandra A. Crook, Ryan A. Peterson, Lauren A. Vanderlinden, Wei Wang, David L. Boyle, William H. Robinson, Jane H. Buckner, Gary S. Firestein, Kevin D. Deane
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Molecular markers of autoimmunity, such as antibodies to citrullinated protein antigens (ACPA), are detectable prior to inflammatory arthritis (IA) in rheumatoid arthritis (RA) and may define a state that is ‘at-risk’ for future RA. Here
Externí odkaz:
https://doaj.org/article/a3d2e67207bd4673ae2092ef39c22e10
Autor:
Bobbie-Jo M. Webb-Robertson, Ernesto S. Nakayasu, Fran Dong, Kathy C. Waugh, Javier E. Flores, Lisa M. Bramer, Athena A. Schepmoes, Yuqian Gao, Thomas L. Fillmore, Suna Onengut-Gumuscu, Ashley Frazer-Abel, Stephen S. Rich, V. Michael Holers, Thomas O. Metz, Marian J. Rewers
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108769- (2024)
Summary: Type 1 diabetes (T1D) is a chronic condition caused by autoimmune destruction of the insulin-producing pancreatic β cells. While it is known that gene-environment interactions play a key role in triggering the autoimmune process leading to
Externí odkaz:
https://doaj.org/article/acc4fc3a7d7e468abe5144f230ae4843
Autor:
Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in bl
Externí odkaz:
https://doaj.org/article/256fdecef1e149f1a62547c63372d7f7
Autor:
V. Michael Holers, Kristine A. Kuhn, M. Kristen Demoruelle, Jill M. Norris, Gary S. Firestein, Eddie A. James, William H. Robinson, Jane H. Buckner, Kevin D. Deane
Publikováno v:
Rheumatology & Autoimmunity, Vol 2, Iss 3, Pp 109-119 (2022)
Abstract In seropositive rheumatoid arthritis (RA), the onset of clinically apparent inflammatory arthritis (IA) is typically preceded by a prolonged period of autoimmunity manifest by the presence of circulating autoantibodies that can include antib
Externí odkaz:
https://doaj.org/article/a023ec5f97084f0d8aed3f54c68b8020
Autor:
V. Michael Holers, Rachel M. Frank, Andrew Clauw, Jennifer Seifert, Michael Zuscik, Sakthi Asokan, Christopher Striebich, Michael R. Clay, Larry W. Moreland, Nirmal K. Banda
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Anterior cruciate ligament (ACL) injury and meniscal tear (MT) are major causal factors for developing post-traumatic osteoarthritis (PTOA), but the biological mechanism(s) are uncertain. After these structural damages, the synovium could be affected
Externí odkaz:
https://doaj.org/article/00b8aa3de9c0458f9f8dd0451e8d1d61
Autor:
Vladislav Tsaltskan, Katherine Nguyen, Christina Eaglin, V. Michael Holers, Kevin D. Deane, Gary S. Firestein
Publikováno v:
ACR Open Rheumatology, Vol 4, Iss 7, Pp 623-630 (2022)
Objective Traditional nondigital methods of participant recruitment for clinical research studies in rheumatology can be costly and inefficient, particularly for recruitment of underserved populations. We aimed to address this need by evaluating two
Externí odkaz:
https://doaj.org/article/69b997f410a745d3b6c6c30bbab64508
Autor:
Leah F. Bettner, Ryan A. Peterson, Dylan T. Bergstedt, Lindsay B. Kelmenson, M. Kristen Demoruelle, Ted R. Mikuls, Jess D. Edison, Mark C. Parish, Marie L. Feser, Ashley A. Frazer‐Abel, Laura K. Moss, Michael Mahler, V. Michael Holers, Kevin D. Deane
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 10, Pp 684-689 (2021)
Objective To evaluate the prevalence of elevations of anti‐cyclic citrullinated peptide‐3 (anti‐CCP3) antibody, rheumatoid factor IgM (RF‐IgM) and serum calprotectin (sCP) in pre–rheumatoid arthritis (RA) as well as the diagnostic accuracie
Externí odkaz:
https://doaj.org/article/a5af5db0fd4a4c6fb7259817c70681c7
Autor:
M. Kristen Demoruelle, Hong Wang, Ryan L. Davis, Ashley Visser, Johnny Hoang, Jill M. Norris, V. Michael Holers, Kevin D. Deane, Erika Darrah
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-8 (2021)
Abstract Background Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3/4), are specific for
Externí odkaz:
https://doaj.org/article/8b0d34044cbf4ad094aefd7bb19d8c18