Zobrazeno 1 - 10
of 60
pro vyhledávání: '"V McNamara"'
Autor:
Hiroshi Momiji, Kirsty L Hassall, Karen Featherstone, Anne V McNamara, Amanda L Patist, David G Spiller, Helen C Christian, Michael R H White, Julian R E Davis, Bärbel F Finkenstädt, David A Rand
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1007030 (2019)
Prolactin is a major hormone product of the pituitary gland, the central endocrine regulator. Despite its physiological importance, the cell-level mechanisms of prolactin production are not well understood. Having significantly improved the resolutio
Externí odkaz:
https://doaj.org/article/2bbb8bc2d77d4092b761e5d67d0c979f
Autor:
Karen Featherstone, Kirsty Hey, Hiroshi Momiji, Anne V McNamara, Amanda L Patist, Joanna Woodburn, David G Spiller, Helen C Christian, Alan S McNeilly, John J Mullins, Bärbel F Finkenstädt, David A Rand, Michael RH White, Julian RE Davis
Publikováno v:
eLife, Vol 5 (2016)
Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over
Externí odkaz:
https://doaj.org/article/4711de80f72b4aca95bc49e34466bac3
Autor:
Michael R. H. White, Sabrina Semprini, Claire V. Harper, Nicholas Jones, David G. Spiller, Karen Featherstone, Anne V McNamara, Antony A Adamson, Hiroshi Momiji, Bärbel Finkenstädt, John J. Mullins, Lee M. Dunham, David A. Rand, Raheela Awais, Julian R. E. Davis
Publikováno v:
Endocrinology
McNamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology, vol. 162, no. 4, bqaa249 . https://doi.org/10.1210/endocr/bqaa249
Mcnamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology . https://doi.org/10.1210/endocr/bqaa249
McNamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology, vol. 162, no. 4, bqaa249 . https://doi.org/10.1210/endocr/bqaa249
Mcnamara, A V, Awais, R, Momiji, H, Dunham, L, Featherstone, K, Harper, C V, Adamson, A A, Semprini, S, Jones, N A, Spiller, D G, Mullins, J J, Finkenstädt, B F, Rand, D, White, M R H & Davis, J R E 2021, ' Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene ', Endocrinology . https://doi.org/10.1210/endocr/bqaa249
Gene transcription occurs in short bursts interspersed with silent periods, and these kinetics can be altered by promoter structure. The effect of alternate promoter architecture on transcription bursting is not known. We studied the human prolactin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3d33d6a6a1eeac0e7aa4fe834e169c
http://wrap.warwick.ac.uk/146862/7/WRAP-Transcription-factor-Pit-1-affects-transcriptional-timing-dual-promoter-human-prolactin-gene-Rand-2021.pdf
http://wrap.warwick.ac.uk/146862/7/WRAP-Transcription-factor-Pit-1-affects-transcriptional-timing-dual-promoter-human-prolactin-gene-Rand-2021.pdf
Autor:
Claire V. Harper, Jayne C Charnock, Anne V McNamara, David G. Spiller, Julian R. E. Davis, Michael R. H. White
Publikováno v:
Journal of Molecular Endocrinology
Pituitary cells have been reported to show spontaneous calcium oscillations and dynamic transcription cycles. To study both processes in the same living cell in real time, we used rat pituitary GH3 cells stably expressing human prolactin-luciferase o
Publikováno v:
Pathology. 52:S115-S116
Autor:
Sabrina Semprini, Antony Adamson, Anne V McNamara, John J. Mullins, Michael R. H. White, Julian R. E. Davis, David G. Spiller, Lee S. S. Dunham, Alan S. McNeilly
Publikováno v:
Molecular Endocrinology
McNamara, A V, Adamson, A D, Dunham, L S S, Semprini, S, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2016, ' Role of Estrogen Response Element in the Human Prolactin Gene : Transcriptional Response and Timing ', Molecular Endocrinology, vol. 30, no. 2, pp. 189-200 . https://doi.org/10.1210/me.2015-1186
Mcnamara, A, Adamson, A, Dunham, L, Semprini, S, Spiller, D, McNeilly, A S, Mullins, J J, Davis, JRE & White, M 2016, ' Role of estrogen response element in the human prolactin gene: transcriptional response and timing ', Molecular Endocrinology, vol. 30, no. 2 . https://doi.org/10.1210/me.2015-1186
McNamara, A V, Adamson, A D, Dunham, L S S, Semprini, S, Spiller, D G, McNeilly, A S, Mullins, J J, Davis, J R E & White, M R H 2016, ' Role of Estrogen Response Element in the Human Prolactin Gene : Transcriptional Response and Timing ', Molecular Endocrinology, vol. 30, no. 2, pp. 189-200 . https://doi.org/10.1210/me.2015-1186
Mcnamara, A, Adamson, A, Dunham, L, Semprini, S, Spiller, D, McNeilly, A S, Mullins, J J, Davis, JRE & White, M 2016, ' Role of estrogen response element in the human prolactin gene: transcriptional response and timing ', Molecular Endocrinology, vol. 30, no. 2 . https://doi.org/10.1210/me.2015-1186
The use of bacterial artificial chromosome (BAC) reporter constructs in molecular physiology enables the inclusion of large sections of flanking DNA, likely to contain regulatory elements and enhancers regions that contribute to the transcriptional o
Autor:
Julian R. E. Davis, Karen Featherstone, David G. Spiller, John J. Mullins, Kirsty Hey, Anne V McNamara, Joanna Woodburn, Michael R. H. White, Amanda L. Patist, Alan S. McNeilly, David A. Rand, Hiroshi Momiji, Bärbel Finkenstädt, Helen C. Christian
Publikováno v:
Featherstone, K, Hey, K, Momiji, H, Mcnamara, A, Patist, A, Woodburn, J, Spiller, D, Christian, H C, McNeilly, A S, Mullins, J J, Finkenstädt, B F, Rand, D A, White, M & Davis, J 2016, ' Spatially coordinated dynamic gene transcription in living pituitary tissue ', eLife, vol. 5, e08494 . https://doi.org/10.7554/eLife.08494
Featherstone, K, Hey, K, Momiji, H, McNamara, A V, Patist, A L, Woodburn, J, Spiller, D G, Christian, H C, McNeilly, A S, Mullins, J J, Finkenstädt, B F, Rand, D A, White, M R & Davis, J R 2016, ' Spatially coordinated dynamic gene transcription in living pituitary tissue ', eLIFE, vol. 5 . https://doi.org/10.7554/eLife.08494
eLife, Vol 5 (2016)
eLife
Featherstone, K, Hey, K, Momiji, H, McNamara, A V, Patist, A L, Woodburn, J, Spiller, D G, Christian, H C, McNeilly, A S, Mullins, J J, Finkenstädt, B F, Rand, D A, White, M R & Davis, J R 2016, ' Spatially coordinated dynamic gene transcription in living pituitary tissue ', eLIFE, vol. 5 . https://doi.org/10.7554/eLife.08494
eLife, Vol 5 (2016)
eLife
Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252999c64f69b734255087e141802c5d
https://www.research.manchester.ac.uk/portal/en/publications/spatially-coordinated-dynamic-gene-transcription-in-living-pituitary-tissue(9a3ba582-ae9b-4b4e-958d-1a2a4aaf9c1d).html
https://www.research.manchester.ac.uk/portal/en/publications/spatially-coordinated-dynamic-gene-transcription-in-living-pituitary-tissue(9a3ba582-ae9b-4b4e-958d-1a2a4aaf9c1d).html
Autor:
Raheela Awais, Julian R. E. Davis, Alan S. McNeilly, John J. Mullins, Adriano G. Rossi, Amanda L. Patist, Karen Featherstone, Claire V. Harper, Anne V McNamara, Sabrina Semprini, Ian Dransfield, Michael R. H. White, J R McNeilly
Publikováno v:
Endocrinology. 153:2724-2734
Prolactin (PRL) is mainly expressed in the pituitary in rodents, whereas in humans, expression is observed in many extrapituitary sites, including lymphocytes. Due to the lack of adequate experimental models, the function of locally produced PRL in t
Autor:
Neil V. McNamara, Margaret R. Janu, George Car, Markus J. Seibel, Roger Chen, Phillip Bwititi
Publikováno v:
Pathology. 41:269-275
The early stages of renal failure are poorly diagnosed by current routine tests. We studied cystatin C and routine renal analyte patterns in Type 2 diabetes mellitus.Type 2 diabetes mellitus patients (n = 48) were tested for serum cystatin C, urine a
Autor:
Alan S. McNeilly, Karen Featherstone, Anne V McNamara, Kirsty Hey, David G. Spiller, John J. Mullins, Michael R. H. White, Bärbel Finkenstädt, Julian R. E. Davis, Helen C. Christian, Joanna Woodburn, Hiroshi Momiji, Amanda L. Patist, David A. Rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae61b51175e58b04c4b1de70eb49a27
https://doi.org/10.7554/elife.08494.026
https://doi.org/10.7554/elife.08494.026