Zobrazeno 1 - 10
of 43
pro vyhledávání: '"V M, Whitehead"'
Autor:
Barton A. Kamen, Bruce M. Camitta, A. Emami, P. A. Koch, D. J. Pullen, M J Vuchich, Jonathan J. Shuster, Linda D. Cooley, J. J. Akabutu, A. T. Look, Yaddanapudi Ravindranath, V M Whitehead, Stephen J. Lauer, C Payment, T Bowen, Donald H. Mahoney, G. P. Beardsley
Publikováno v:
Leukemia & Lymphoma. 31:507-519
Levels of accumulation of methotrexate polyglutamates were measured in vitro in lymphoblasts obtained at diagnosis from children with B-progenitor cell acute lymphoblastic leukemia (pro-B ALL). They were compared to numerical and structural chromosom
Autor:
R. G. Duncan, Barry Shane, Xiao-Ning Chen, Timothy A. Garrow, Julie R. Korenberg, A. A. Brenner, V. M. Whitehead
Publikováno v:
Journal of Biological Chemistry. 268:11910-11916
Human cDNAs for cytosolic and mitochondrial serine hydroxymethyltransferase (SHMT) were cloned by functional complementation of an Escherichia coli glyA mutant with a human cDNA library. The cDNA for the cytosolic enzyme encodes a 483-residue protein
Autor:
M J Vuchich, D Mahoney, Jonathan J. Shuster, SJ Lauer, J Akabutu, C Payment, V M Whitehead, AT Look, DW Esseltine, AJ Carroll
Publikováno v:
Blood. 80:1316-1323
Hyperdiploidy (greater than 50 chromosomes, or a DNA index greater than 1.16) confers a favorable prognosis in B-lineage acute lymphoblastic leukemia of childhood. Children with B-lineage acute lymphoblastic leukemia whose lymphoblasts at diagnosis a
Autor:
V. M. Whitehead, T. Holbrook, Beverly Bell, Abdelsalam H. Ragab, M. E. Haggard, Harry W. Findley, J. Krischer, M. Hensley, P. N. Konrad
Publikováno v:
Journal of Immunotherapy. 10:77-83
Forty-one patients with refractory acute non-lymphocytic leukemia (ANLL) in relapse were treated with 13-cis-retinoic acid (cRA) as salvage therapy. The cRA was given as a single oral dose of 100 mg/m2/day for 4 weeks. One patient achieved a complete
Publikováno v:
Blood. 76:44-49
Lymphoblasts in bone marrow samples, obtained from 43 children with acute lymphoblastic leukemia at diagnosis, were incubated with 1.0 mumols/L [3H] methotrexate for 24 hours in vitro. Nonexchangeable methotrexate and methotrexate polyglutamates were
Publikováno v:
Blood. 76:44-49
Lymphoblasts in bone marrow samples, obtained from 43 children with acute lymphoblastic leukemia at diagnosis, were incubated with 1.0 mumols/L [3H] methotrexate for 24 hours in vitro. Nonexchangeable methotrexate and methotrexate polyglutamates were
Autor:
Linda D. Cooley, J J Shuster, Stephen J. Lauer, Donald H. Mahoney, M J Vuchich, Bruce M. Camitta, D. J. Pullen, Mark L. Bernstein, A T Look, V M Whitehead, C Payment
Publikováno v:
Leukemia. 15(7)
Lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia (BpALL) with chromosomal hyperdiploidy and with translocations affecting chromosome 12p11-13, accumulate high and low levels of methotrexate polyglutamates (MTXPGs), respe
Autor:
D S, Rosenblatt, V M, Whitehead
Publikováno v:
Seminars in hematology. 36(1)
This review highlights the features of cobalamin and folate deficiency and insufficiency that are particular to children. Maternal deficiency of cobalamin and insufficiency or deficiency of folate are the principal causes of deficiencies of these vit
Autor:
V M, Whitehead, M J, Vuchich, L, Cooley, S J, Lauer, D H, Mahoney, J J, Shuster, C, Payment, M L, Bernstein, J J, Akabutu, T, Bowen, B A, Kamen, M S, Watson, A T, Look, D J, Pullen, B, Camitta
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(1)
Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate (MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivi
Autor:
M L, Graham, J J, Shuster, B A, Kamen, V J, Land, M J, Borowitz, B, Camitta, D L, Cheo, M P, Harrison, B G, Leventhal, D P, Pinkel, D J, Pullen, P, Steuber, V M, Whitehead
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(2)
Since it is unclear whether methotrexate and cytarabine are synergistic or antagonistic in the treatment of acute lymphoblastic leukemia, the Pediatric Oncology Group studied the prognostic significance of a potential interaction between these agents