Zobrazeno 1 - 6
of 6
pro vyhledávání: '"V M, Traina"'
Publikováno v:
Experimental and Toxicologic Pathology. 46:119-125
Summary Peripheral toxic neuropathy induced in rats with a 5-lipoxygenase inhibitor CGS 21 595 was characterized using special functional tests and pathological procedures. Functional tests included measurement of grip strength, landing foot splay, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84cd11c5ac8469b96c4794654cbb0d2
https://doi.org/10.1016/s0940-2993(11)80038-2
https://doi.org/10.1016/s0940-2993(11)80038-2
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 35(2)
Many marketed pharmaceuticals are known to cause idiosyncratic agranulocytosis in humans. Similarly prinomide, an antiinflammatory drug, was associated with a low incidence of agranulocytosis (0.3%) in clinical trials, even though chronic toxicity st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fb4317036478ce84aad0fe0b65a9f2
https://pubmed.ncbi.nlm.nih.gov/9038241
https://pubmed.ncbi.nlm.nih.gov/9038241
Publikováno v:
Veterinary pathology. 29(2)
Male and female Sprague-Dawley rats were given CGS 21595, a pro-drug that is almost immediately metabolized to CGS 19213, a naphthoquinone that acts as a 5-lipoxygenase inhibitor. The compound was administered by gavage to five groups of Sprague-Dawl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0f8273a176a54e59a5b25a2d977412
https://pubmed.ncbi.nlm.nih.gov/1632058
https://pubmed.ncbi.nlm.nih.gov/1632058
Publikováno v:
Toxicological Sciences. 10:329-334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43024e42bf076b42178a4bf661331258
https://doi.org/10.1093/toxsci/10.2.329
https://doi.org/10.1093/toxsci/10.2.329
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 10(2)
CGS 14796C, cis-1-[(4-[(1-imidazolyl)methyl]-cyclohexyl)methyl)imidazole succinate, has been evaluated as a potential aromatase inhibitor. As part of the safety evaluation program, a 3-month oral toxicity study was performed in which beagle dogs were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59f8fa99ef179340e805df5eb6b77e37
https://pubmed.ncbi.nlm.nih.gov/3356320
https://pubmed.ncbi.nlm.nih.gov/3356320
Publikováno v:
Antimicrobial agents and chemotherapy. 3(6)
Cephradine, a semisynthetic cephalosporin antibiotic, has a low order of oral and parenteral toxicity in animals. The oral LD 50 in mice and rats ranged from 5 to >8 g/kg, and the intraperitoneal LD 50 values in mice and rats were 0.7 to 1.5 g/kg and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7729052f70bf1b1a81c18c33a06fe85
https://pubmed.ncbi.nlm.nih.gov/4790617
https://pubmed.ncbi.nlm.nih.gov/4790617