Zobrazeno 1 - 10
of 101
pro vyhledávání: '"V M, Kavsan"'
Autor:
Yegor S. Vassetzky, V. M. Kavsan, Dmytro Mykytenko, A. A. Stepanenko, Kateryna Korets, S V Andreieva, Nataliya Huleyuk
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 771:56-69
The pattern of genome evolution can be divided into two phases: the step-wise continuous phase (step-wise clonal evolution, stable dominant clonal chromosome aberrations (CCAs), and low frequency of non-CCAs, NCCAs) and punctuated phase (marked by el
Autor:
A. A. Stepanenko, V. M. Kavsan
Publikováno v:
Evolutionary Thinking in Medicine ISBN: 9783319297149
A long-held and dominating view that cancer is a genetic disease caused by deterministic sequential mutations in a restricted number of cancer-driver genes (oncogenes and tumour suppressor genes), occurring in a continuous linear pattern of tumour pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a48227b72a18b21d1005e3f51f23101
https://doi.org/10.1007/978-3-319-29716-3_13
https://doi.org/10.1007/978-3-319-29716-3_13
Autor:
V. M. Kavsan, A. A. Stepanenko
Publikováno v:
Biopolymers and Cell, Vol 28, Iss 4, Pp 267-280 (2012)
Согласно общепризнанной генной теории рака, в течение последних десятилетий рак считали генным заболеванием, возникающим в результате
Autor:
V. M. Kavsan, A. A. Stepanenko
Publikováno v:
Cytology and Genetics. 46:96-129
The process of cellular transformation has been amply studied in vitro using immortalized cell lines. Immortalized cells never have the normal diploid karyotype, nevertheless, they cannot grow over one another in cell culture (contact inhibition), do
Publikováno v:
Hybridoma. 31:32-39
Chitinase 3-like 2 (CHI3L2) is one of the most overexpressed genes in glioblastoma. Despite this, both the CHI3L2 gene and its protein product CHI3L2 are poorly characterized. Here we report the generation and characterization of monoclonal antibodie
Autor:
V. M. Kavsan, Olena V. Balynska, Vladimir P. Baklaushev, Vladimir P. Chekhonin, Maxim A. Abakumov, G. M. Yusubalieva
Publikováno v:
British Journal of Medicine and Medical Research. 2:206-215
Aims: Xenograft models, namely heterotransplantation of human cancer cells or tumor biopsies into immunodeficient rodents are the major preclinical approach for the development of novel cancer therapeutics. However, in these models the animals must b
Publikováno v:
Biopolymers and Cell, Vol 27, Iss 5, Pp 343-346 (2011)
Scopus-Elsevier
Scopus-Elsevier
Aim. To determine 293 and U373 cell response and ERK1/2 activation profile after CHI3L1 or CHI3L2 treatment. Methods. Specific activation and localization of ERK1/2 kinases after CHI3L1 or CHI3L2 addition to unsupplemented cell medium were evaluated
Autor:
Stanislav Avdieiev, Vladimir P. Chekhonin, Vladimir P. Baklaushev, V. M. Kavsan, P. O. Areshkov, O. I. Boyko, Olena V. Balynska
Publikováno v:
Scopus-Elsevier
Biopolymers and Cell, Vol 27, Iss 4, Pp 285-290 (2011)
Biopolymers and Cell, Vol 27, Iss 4, Pp 285-290 (2011)
Aim. To characterize the immortalized 293 cell line afterstable transfection with human oncogene (CHI3L1). Methods. 293 cells, stably transfected with pcDNA3.1_CHI3L1, and 293 cells, stably transfected with pcDNA3.1 as a negative control, were used t
Autor:
T. A. Malysheva, V. M. Kavsan, L. L. Sidorik, V. D. Rozumenko, Y. P. Zozulya, Anna V. El'skaya, Boris Negrutskii, M. V. Veremieva
Publikováno v:
Biopolymers and Cell, Vol 26, Iss 4, Pp 317-321 (2010)
Scopus-Elsevier
Scopus-Elsevier
Aim. To investigate protein level of all subunits of the eukaryotic elongation translation factor eEF1H (eEF1A, eEF1Bα, eEF1Bβ and eEF1Bγ) in glial tumors of human brain in comparison with normal brain. Methods. The eEF1H components content has be
Autor:
A. A. Mekler, V. I. Rymar, Y. A. Kuperin, V. M. Kavsan, D. R. Schwartz, V. V. Dmitrenko, I. Knyazeva
Publikováno v:
Optical Memory and Neural Networks. 19:181-186
Two artificial neural networks of different types were applied to gene expression profiles in glioblastoma, the most aggressive human brain tumor, and in normal brain tissue. The results of gene expression profiles classification are presented. First