Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells

Autor: Pedro Sousa-Victor, Arshad Ayyaz, Rippei Hayashi, Yanyan Qi, David T. Madden, Victoria V. Lunyak, Heinrich Jasper

Publikováno v: Cell Reports, Vol 20, Iss 11, Pp 2527-2537 (2017)

Sophisticated mechanisms that preserve genome integrity are critical to ensure the maintenance of regenerative capacity while preventing transformation of somatic stem cells (SCs), yet little is known about mechanisms regulating genome maintenance in

Externí odkaz: https://doaj.org/article/00b9bcff187548a59b3464868d8679b1

Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective

Autor: Victoria V. Lunyak, Alexandra Amaro-Ortiz, Meenakshi Gaur

Publikováno v: Frontiers in Genetics, Vol 8 (2017)

Mesenchymal stem/stromal cells (MSC) have been tested in a significant number of clinical trials, where they exhibit regenerative and repair properties directly through their differentiation into the cells of the mesenchymal origin or by modulation o

Externí odkaz: https://doaj.org/article/728a9bb1f6ac4c00836753f192fb154c

Adipose stem cells from obese patients show specific differences in the metabolic regulators vitamin D and Gas5

Autor: Beatriz G. Gálvez, Victoria V. Lunyak, Beatriz de Lucas, Laura M. Pérez

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Molecular Genetics and Metabolism Reports, Vol 12, Iss C, Pp 51-56 (2017)
Molecular Genetics and Metabolism Reports

Adipose tissue is a significant source of mesenchymal stem cells for regenerative therapies; however, caution should be taken as their environmental niche can affect their functional properties. We have previously demonstrated the negative impact of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f93151f76f58f1f6729effbe3ee08f
https://doi.org/10.1016/j.ymgmr.2017.05.008

Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence

Autor: I. King Jordan, Aliya Nussupbekova, Akan A. Akanov, Aiman Sadvakasovna Sadvakas, Ping Niu, Aibek Smagul, Victoria V. Lunyak, Ying Sha, Beatriz G. Gálvez, Aday Amirbekov, Lu Wang, Laura M. Pérez

Publikováno v: Oncotarget
ResearcherID
Repisalud
Instituto de Salud Carlos III (ISCIII)
Scopus-Elsevier

Inflammation is a double-edged sword with both detrimental and beneficial consequences. Understanding of the mechanisms of crosstalk between the inflammatory milieu and human adult mesenchymal stem cells is an important basis for clinical efforts. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf0ca1c5e4de77dc3a06388e2a63972
https://doi.org/10.18632/oncotarget.4852

Opposing activities of oncogenic MIR17HG and tumor suppressive MIR100HG clusters and their gene targets regulate replicative senescence in human adult stem cells

Autor: Yue-Qiang Zhao, Victoria V. Lunyak, Aibek Smagul, Mary F. Lopez, Maryann Vogelsang, Lu Wang, Ping Niu, I. King Jordan, Bryan Krastins, Meenakshi Gaur, Aliya Nussupbekova, Aikan A. Akanov

Publikováno v: NPJ aging and mechanisms of disease
npj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-15 (2017)
NPJ Aging and Mechanisms of Disease

Growing evidence suggests that many diseases of aging, including diseases associated with robust changes and adipose deports, may be caused by resident adult stem cell exhaustion due to the process called cellular senescence. Understanding how microR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6569e4dd621624b8a448bf6c73970cb7