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Akademický článek

Synthesis and anaigetical activity of derivatives of 1-indolilethil-3-pirrolin-2-ones

Autor: N V Dozmorova, V L Gein, N N Kasimova, L I Varkentin, B Ya Syropyatov, N V Danilova

Publikováno v: RUDN Journal of Medicine, Vol 0, Iss 4, Pp 378-380 (2009)

Interaction of methyl esters of acylpyruvic acides with mixture of aromatic aldehyde and tryptamine or 5-methoxytryptamine leads to 5-aryl-4-acyl-3-hydroxy-1-[2-(3-indolil)-ethyl)-2,5-dihydropyrrol-2-ones (I). The compounds (I) were transformed to 3,

Externí odkaz: https://doaj.org/article/7d9905fcf49843d5a50977e9b91282d5

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Akademický článek

Antimicrobial Activity of New N-substituted Amides of Aroylpyruvic Acids and Their Silver Salts

Autor: V. V. Novikova, V. O. Vasilev, V. L. Gein, O. V. Nazarets, A. V. Romanova, O. V. Bobrovskaya, N. A. Buzmakova

Publikováno v: Разработка и регистрация лекарственных средств, Vol 12, Iss 4, Pp 34-40 (2023)

Introduction. An important direction of modern pharmacy is the production of new domestic substances with anti-infectious activity, within the framework of ensuring the technological sovereignty of the state. Optimization of methods for determining a

Externí odkaz: https://doaj.org/article/07f4accdcf2d41a3a03569a0d6175710

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Akademický článek

Synthesis and Quality Control of Calcium Chelidonate Substance with Osteogenic Activity

Autor: E. Yu. Avdeeva, N. M. Igidov, V. L. Gein, S. V. Krivoshchekov, I. A. Khlusov, M. V. Belousov, N. V. Dozmorova, V. G. Luzhanin

Publikováno v: Разработка и регистрация лекарственных средств, Vol 12, Iss 4, Pp 47-52 (2023)

Introduction. Osteogenic agents are used for pathologies associated with impaired bone formation, complications of bone fractures, the use of implants and endoprostheses, and tumor lesions of bone tissue. High osteogenic activity in vivo on the model

Externí odkaz: https://doaj.org/article/9cdb4ed9e98343f0b8d8bb5b874f8536

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Akademický článek

Development and Validation of Conditions for the Determination of Residual Organic Solvents – Acetic Acid in the Silver Salt Substance 4-[4-(atsetilaminosul'fonil)fenil]-6-(4-bromfenil)-5-(2-nitrofenil)-3,5-digidropirrolo[3,4-с]pirazol-3-ona

Autor: E. N. Lyust, O. V. Bobrovskaya, V. L. Gein

Publikováno v: Разработка и регистрация лекарственных средств, Vol 11, Iss 4, Pp 73-78 (2022)

Introduction. For new synthesized pharmacologically active compounds, already at the stage of standardization, it is necessary to develop methods for determining their quality indicators, normalized by a pharmacopoeial article for pharmaceutical subs

Externí odkaz: https://doaj.org/article/e5d785ac476641a48c3480694baa4049

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Akademický článek

In-Depth Investigation of Antifungal Activity of Compounds of Series of Silver Salts of Pyrazol-3-Carboxamids

Autor: V. V. Novikova, V. L. Gein

Publikováno v: Антибиотики и Химиотерапия, Vol 63, Iss 9-10, Pp 10-13 (2020)

The aim of the study was to investigate the antifungal activity of 4 new promising compounds of pyrazole-3-carboxamides containing silver ion in relation to clinical isolates of Candida spp. using the micromethod of two-fold serial dilution in liquid

Externí odkaz: https://doaj.org/article/46770144b0b44b7aa9b67a66e468c077

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