Zobrazeno 1 - 10 of 18 pro vyhledávání: '"V L Cohan"'
1
Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells
Autor: J. Angilly, H. J. Showell, M. Mansour, S. J. Hawrylik, V. L. Cohan, Craig M. Lilly, M. J. Conklyn, B. Nalcerio, S. E. Lee, M. Karmilowicz, Dennis E. Danley, Jeffrey M. Drazen, J. R. De Wet, D. D. Auperin
Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 270:L1002-L1007
To study the role interleukin (IL)-5 may play in altering airway function in asthma, we have produced recombinant protein for exogenous administration to guinea pigs. The guinea pig IL-5 (gpIL-5) cDNA was cloned by polymerase chain reaction (PCR) amp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3fe82186f65574491fb1a082b2edf2
https://doi.org/10.1152/ajplung.1996.270.6.l1002
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4
ChemInform Abstract: Biarylcarboxamide Inhibitors of Phosphodiesterase IV and Tumor Necrosis Factor-α
Autor: E. R. Pettipher, Allen J. Duplantier, K. L. Johnson, Kenneth G. Kraus, R. J. Chambers, T. A. Hibbs, John B. Cheng, Anthony Marfat, E. D. Salter, John P. Umland, T. H. Jenkinson, J.T. Shirley, V. L. Cohan, David B. Damon
Publikováno v: ChemInform. 28
Tumor necrosis factor-α (TNF-α) has been implicated as a key mediator in the progression of rheumatoid arthritis. Inhibitors of phosphodiesterase IV (PDE IV) have been shown to inhibit the production of TNF-α by elevating intracellular levels of c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8b4411bdb87585bc5d357137963c635
https://doi.org/10.1002/chin.199729128
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5
Multiple antigen challenge produces pulmonary eosinophilia but not pulmonary hyperresponsiveness in actively sensitized guinea pigs
Autor: J. W. Watson, V. L. Cohan, K. W. Freiert, A. K. Shay
Publikováno v: Agents and Actions. 37:174-177
Exposure of actively sensitized boosted guinea pigs to aerosolized antigen, 3 times on alternate days, produced pulmonary eosinophilia but not pulmonary hyperresponsiveness to methacholine Cl measured 3 days after the last antigen challenge. These da
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d45778e7e6a75a0e6eca59cf5aae749
https://doi.org/10.1007/bf02028101
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6
Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology
Autor: W A Massey, C B Guo, A M Dvorak, W C Hubbard, B S Bhagavan, V L Cohan, J A Warner, A Kagey-Sobotka, L M Lichtenstein
Publikováno v: The Journal of Immunology. 147:1621-1627
As part of an ongoing investigation of human mast cell heterogeneity, we have isolated, partially purified, and characterized the uterine mast cell and compared it with mast cells isolated from other organs. The average histamine content of myometriu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::205b49cf1a81bac260bea31acc20c999
https://doi.org/10.4049/jimmunol.147.5.1621
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7
The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy
Autor: J B, Cheng, J W, Watson, C J, Pazoles, J D, Eskra, R J, Griffiths, V L, Cohan, C R, Turner, H J, Showell, E R, Pettipher
Publikováno v: The Journal of pharmacology and experimental therapeutics. 280(2)
Rolipram was previously reported to elevate plasma cyclic adenosine 3',5'-monophosphate (cAMP) and inhibit serum tumor necrosis factor-alpha (TNF-alpha) production in mice. CP-80,633, a new cyclic nucleotide phosphodiesterase (PDE4) inhibitor, has be
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::74190061f47b2e92bb53526ae046cbec
https://pubmed.ncbi.nlm.nih.gov/9023272
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8
The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4
Autor: C R, Turner, V L, Cohan, J B, Cheng, H J, Showell, C J, Pazoles, J W, Watson
Publikováno v: The Journal of pharmacology and experimental therapeutics. 278(3)
The following studies were conducted to characterize the bron-chodilatory and antiinflammatory activity of the novel, selective phosphodiesterase-IV inhibitor, CP-80,633 (2'S)5-[3-(2'-exobicyclo[2.2.1]heptyloxy-4-methoxy-phenyl]te trahydro- 2(1H)-pyr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a010f58f18db8d89fa802dd5f7485611
https://pubmed.ncbi.nlm.nih.gov/8819522
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9
In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633
Autor: V L, Cohan, H J, Showell, D A, Fisher, C J, Pazoles, J W, Watson, C R, Turner, J B, Cheng
Publikováno v: The Journal of pharmacology and experimental therapeutics. 278(3)
We present the in vitro pharmacology of a novel adenosine 3'-5' -cyclic monophosphate-specific phosphodiesterase (PDE) type 4 inhibitor, CP-80633 ((2'S)5-[3-(2' -exobicyclo[2.2.1]-heptyloxy)4-methoxyphenyl] tetrahydro-2(1H)-primidone), which has show
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::135972e0869869d6537698f0af92a641
https://pubmed.ncbi.nlm.nih.gov/8819523
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10
Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid
Autor: J B, Cheng, J S, Pillar, J T, Shirley, H J, Showell, J W, Watson, V L, Cohan
Publikováno v: The Journal of pharmacology and experimental therapeutics. 264(2)
Eosinophil peroxidase (EPO) has been used previously to detect the number of eosinophils in the peritoneal exudate and bone marrow of mice. The present study was undertaken to determine 1) whether EPO activity may provide a measure of a change in eos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::715fcd2986cabd6f1ffd995999c82804
https://pubmed.ncbi.nlm.nih.gov/8437132
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