Výsledky vyhledávání - "V L, Lucaites"

m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT2C receptors but not 5-HT2A or 5-HT2B receptors

Autor: H E Shannon, D L Nelson, V L Lucaites, Scott D. Gleason, J D Leander

Publikováno v: Behavioural Pharmacology. 12:613-620

The ability of m-CPP [1-(m-chlorophenyl)piperazine] to produce hypolocomotion is well documented. This effect has been postulated to be due to activation of the 5-HT(2C) receptor. It is only recently that the tools necessary to clearly delineate whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48230b1843ae8ddc7192ee0a019a3ce
https://doi.org/10.1097/00008877-200112000-00005

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Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation

Autor: David B. Wainscott, David L. Nelson, J E Audia, Kirk W. Johnson, WM Owton, DK Dieckman, V L Lucaites, Lee A. Phebus

Publikováno v: Cephalalgia : an international journal of headache. 23(2)

The compound m-chlorophenylpiperazine (mCPP), which is known to trigger migraine-like head pain in some subjects, was evaluated for its ability to induce dural plasma protein extravasation (PPE) in guinea pigs. Intravenous mCPP dose-dependently incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5485b4c98337f1d91332afad801a229
https://pubmed.ncbi.nlm.nih.gov/12603368

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Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors

Autor: D L, Nelson, V L, Lucaites, D B, Wainscott, R A, Glennon

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 359(1)

Since the classical hallucinogens were initially reported to produce their behavioral effects via a 5-HT2 agonist mechanism (i.e., the 5-HT2 hypothesis of hallucinogen action), 5-HT2 receptors have been demonstrated to represent a family of receptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::25ee98dab1d68dbe018a4939dac5373c
https://pubmed.ncbi.nlm.nih.gov/9933142

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Pharmacologic characterization of the human 5-hydroxytryptamine2B receptor: evidence for species differences

Autor: D B, Wainscott, V L, Lucaites, J D, Kursar, M, Baez, D L, Nelson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 276(2)

The 5-Hydroxytryptamine2B (5-HT2B) receptor was cloned originally from rat stomach fundus and its pharmacology was determined to be consistent with that of the receptor responsible for contraction of rat fundal tissue in response to 5-HT. Recently, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10a1f6982591e51c694bd98c3cc4b44d
https://pubmed.ncbi.nlm.nih.gov/8632342

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Species differences in the pharmacology of the 5-hydroxytryptamine2 receptor: structurally specific differentiation by ergolines and tryptamines

Autor: D L, Nelson, V L, Lucaites, J E, Audia, J S, Nissen, D B, Wainscott

Publikováno v: The Journal of pharmacology and experimental therapeutics. 265(3)

Species differences in the recognition of a series of ergolines by the 5-hydroxytryptamine2 (5-HT2, serotonin2) receptor were investigated in four species, the rat, pig, squirrel monkey and human. In pig frontal cortical membranes the initial studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e410c82d6069dfb769c60e573b2d1f8c
https://pubmed.ncbi.nlm.nih.gov/8510008

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Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor

Autor: D B, Wainscott, M L, Cohen, K W, Schenck, J E, Audia, J S, Nissen, M, Baez, J D, Kursar, V L, Lucaites, D L, Nelson

Publikováno v: Molecular pharmacology. 43(3)

The rat 5-hydroxytryptamine (5-HT)2F (serotonin2F) receptor is a newly cloned member of the 5-HT2/1C receptor family. The pharmacology of the 5-HT2F receptor was explored using a variety of structurally different compounds in a radioligand binding as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3764285677aad99b350ae07cad9f0015
https://pubmed.ncbi.nlm.nih.gov/8450835

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CCK-8, CCK-4 and gastrin-induced contractions in guinea pig ileum: evidence for differential release of acetylcholine and substance P by CCK-A and CCK-B receptors

Autor: V L, Lucaites, L G, Mendelsohn, N R, Mason, M L, Cohen

Publikováno v: The Journal of pharmacology and experimental therapeutics. 256(2)

The cholecystokinin (CCK) receptor involved in contraction of guinea pig ileal longitudinal muscle to cholecystokinin is poorly understood; some studies have suggested that contraction was mediated via a CCK-A receptor whereas other studies have impl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7cce4c34fbe6e06a04ca41011f94f39
https://pubmed.ncbi.nlm.nih.gov/1704435

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Protein kinase C translocation in rat stomach fundus: effects of serotonin, carbamylcholine and phorbol dibutyrate

Autor: R J, Secrest, V L, Lucaites, L G, Mendelsohn, M L, Cohen

Publikováno v: The Journal of pharmacology and experimental therapeutics. 256(1)

In an effort to characterize serotonergic receptor activation in rat stomach fundus, the potential role of protein kinases, more specifically protein kinase C (PKC), in serotonin-induced contraction of rat stomach fundus was examined. Staurosporine,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f9b52c91537b4d4191d43c51b1482b7
https://pubmed.ncbi.nlm.nih.gov/1988650

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