Zobrazeno 1 - 10
of 54
pro vyhledávání: '"V L, Cohan"'
Autor:
J. Angilly, H. J. Showell, M. Mansour, S. J. Hawrylik, V. L. Cohan, Craig M. Lilly, M. J. Conklyn, B. Nalcerio, S. E. Lee, M. Karmilowicz, Dennis E. Danley, Jeffrey M. Drazen, J. R. De Wet, D. D. Auperin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 270:L1002-L1007
To study the role interleukin (IL)-5 may play in altering airway function in asthma, we have produced recombinant protein for exogenous administration to guinea pigs. The guinea pig IL-5 (gpIL-5) cDNA was cloned by polymerase chain reaction (PCR) amp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3fe82186f65574491fb1a082b2edf2
https://doi.org/10.1152/ajplung.1996.270.6.l1002
https://doi.org/10.1152/ajplung.1996.270.6.l1002
Autor:
G.W. Antognoli, J.T. Shirley, A. Marfat, C.F. Wright, Thomas J. Carty, Frank W. Rusek, J. W. Watson, J. Delehunt, B. A. Naclerio, James F. Eggler, J.S. Pillar, Herbert Sherman, E.G. Andrews, Francis J. Sweeney, K. W. Freiert, R. Breslow, C. J. Mularski, V. L. Cohan, C J Pazoles, Lawrence S. Melvin, L.A. Rappach, John B. Cheng, David B. Damon, Jeanene E. Tickner, Judith L. Collins, P. Reiche, Hiroko Masamune, M. P. Carta, James D. Eskra, Hada William Andrew, R. J. Chambers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1365-1370
The development of two novel LTD 4 receptor antagonists as clinical candidates for the treatment of asthma is described. The first generation compound, CP-80,798, was found to be a balanced 5-lipoxygenase inhibitor (5-LOI)/LTD 4 antagonist (LTD 4 -A)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a5fced5f481925dbd55bd727448996c
https://doi.org/10.1016/0960-894x(95)00225-i
https://doi.org/10.1016/0960-894x(95)00225-i
Autor:
E. G. ANDREWS, G. W. ANTOGNOLI, R. BRESLOW, M. P. CARTA, T. J. CARTY, R. J. CHAMBERS, J. B. CHENG, V. L. COHAN, J. L. COLLINS, D. B. DAMON, J. DELEHUNT, J. F. EGGLER, J. D. ESKRA, K. W. FREIERT, W. A. HADA, A. MARFAT, H. MASAMUNE, L. S. MELVIN, C. J. MULARSKI, B. A. NACLERIO, et al. et al.
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c628a89c65d567bd8f9cac390f92e716
https://doi.org/10.1002/chin.199544142
https://doi.org/10.1002/chin.199544142
Autor:
E. R. Pettipher, Allen J. Duplantier, K. L. Johnson, Kenneth G. Kraus, R. J. Chambers, T. A. Hibbs, John B. Cheng, Anthony Marfat, E. D. Salter, John P. Umland, T. H. Jenkinson, J.T. Shirley, V. L. Cohan, David B. Damon
Publikováno v:
ChemInform. 28
Tumor necrosis factor-α (TNF-α) has been implicated as a key mediator in the progression of rheumatoid arthritis. Inhibitors of phosphodiesterase IV (PDE IV) have been shown to inhibit the production of TNF-α by elevating intracellular levels of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8b4411bdb87585bc5d357137963c635
https://doi.org/10.1002/chin.199729128
https://doi.org/10.1002/chin.199729128
Publikováno v:
Agents and Actions. 37:174-177
Exposure of actively sensitized boosted guinea pigs to aerosolized antigen, 3 times on alternate days, produced pulmonary eosinophilia but not pulmonary hyperresponsiveness to methacholine Cl measured 3 days after the last antigen challenge. These da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d45778e7e6a75a0e6eca59cf5aae749
https://doi.org/10.1007/bf02028101
https://doi.org/10.1007/bf02028101
Autor:
W A Massey, C B Guo, A M Dvorak, W C Hubbard, B S Bhagavan, V L Cohan, J A Warner, A Kagey-Sobotka, L M Lichtenstein
Publikováno v:
The Journal of Immunology. 147:1621-1627
As part of an ongoing investigation of human mast cell heterogeneity, we have isolated, partially purified, and characterized the uterine mast cell and compared it with mast cells isolated from other organs. The average histamine content of myometriu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::205b49cf1a81bac260bea31acc20c999
https://doi.org/10.4049/jimmunol.147.5.1621
https://doi.org/10.4049/jimmunol.147.5.1621
Autor:
J B, Cheng, J W, Watson, C J, Pazoles, J D, Eskra, R J, Griffiths, V L, Cohan, C R, Turner, H J, Showell, E R, Pettipher
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
Rolipram was previously reported to elevate plasma cyclic adenosine 3',5'-monophosphate (cAMP) and inhibit serum tumor necrosis factor-alpha (TNF-alpha) production in mice. CP-80,633, a new cyclic nucleotide phosphodiesterase (PDE4) inhibitor, has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74190061f47b2e92bb53526ae046cbec
https://pubmed.ncbi.nlm.nih.gov/9023272
https://pubmed.ncbi.nlm.nih.gov/9023272
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(3)
The following studies were conducted to characterize the bron-chodilatory and antiinflammatory activity of the novel, selective phosphodiesterase-IV inhibitor, CP-80,633 (2'S)5-[3-(2'-exobicyclo[2.2.1]heptyloxy-4-methoxy-phenyl]te trahydro- 2(1H)-pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a010f58f18db8d89fa802dd5f7485611
https://pubmed.ncbi.nlm.nih.gov/8819522
https://pubmed.ncbi.nlm.nih.gov/8819522
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(3)
We present the in vitro pharmacology of a novel adenosine 3'-5' -cyclic monophosphate-specific phosphodiesterase (PDE) type 4 inhibitor, CP-80633 ((2'S)5-[3-(2' -exobicyclo[2.2.1]-heptyloxy)4-methoxyphenyl] tetrahydro-2(1H)-primidone), which has show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::135972e0869869d6537698f0af92a641
https://pubmed.ncbi.nlm.nih.gov/8819523
https://pubmed.ncbi.nlm.nih.gov/8819523
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 264(2)
Eosinophil peroxidase (EPO) has been used previously to detect the number of eosinophils in the peritoneal exudate and bone marrow of mice. The present study was undertaken to determine 1) whether EPO activity may provide a measure of a change in eos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::715fcd2986cabd6f1ffd995999c82804
https://pubmed.ncbi.nlm.nih.gov/8437132
https://pubmed.ncbi.nlm.nih.gov/8437132