Zobrazeno 1 - 10
of 25
pro vyhledávání: '"V Keith Hughitt"'
Autor:
Stephen M Christensen, Laura A L Dillon, Lucas P Carvalho, Sara Passos, Fernanda O Novais, V Keith Hughitt, Daniel P Beiting, Edgar M Carvalho, Phillip Scott, Najib M El-Sayed, David M Mosser
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005588 (2017)
[This corrects the article DOI: 10.1371/journal.pntd.0004992.].
Externí odkaz:
https://doaj.org/article/262fd8a16d9c4656b73e29de65da7b1f
Autor:
Stephen M Christensen, Laura A L Dillon, Lucas P Carvalho, Sara Passos, Fernanda O Novais, V Keith Hughitt, Daniel P Beiting, Edgar M Carvalho, Phillip Scott, Najib M El-Sayed, David M Mosser
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004992 (2016)
Host and parasite gene expression in skin biopsies from Leishmania braziliensis-infected patients were simultaneously analyzed using high throughput RNA-sequencing. Biopsies were taken from 8 patients with early cutaneous leishmaniasis and 17 patient
Externí odkaz:
https://doaj.org/article/bb0256dc2d5a46f3b743829cc856a81b
Autor:
Xiuxiu Lu, Monika Chandravanshi, Venkata R. Sabbasani, Snehal Gaikwad, V. Keith Hughitt, Nana Gyabaah-Kessie, Bradley T. Scroggins, Sudipto Das, Wazo Myint, Michelle E. Clapp, Charles D. Schwieters, Marzena A. Dyba, Derek L. Bolhuis, Janusz W. Koscielniak, Thorkell Andresson, Michael J. Emanuele, Nicholas G. Brown, Hiroshi Matsuo, Raj Chari, Deborah E. Citrin, Beverly A. Mock, Rolf E. Swenson, Kylie J. Walters
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of an intact proteasome- and ubiquitin-binding Pru domain. By using s
Externí odkaz:
https://doaj.org/article/287afc8f95ca4e0dbcecccb50eebdb48
Autor:
Anju Kumari, Lisa Gesumaria, Yan-Jin Liu, V. Keith Hughitt, Xiaohu Zhang, Michele Ceribelli, Kelli M. Wilson, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Craig J. Thomas, Beverly A. Mock, David S. Schrump, Haobin Chen
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Small cell lung cancer (SCLC) is a recalcitrant malignancy with limited treatment options. Bromodomain and extraterminal domain inhibitors (BETis) have shown promising preclinical activity in SCLC, but the broad sensitivity spectrum limits their clin
Externí odkaz:
https://doaj.org/article/486952269d6442e6887641df9fd39b64
Autor:
Jeff Quigley, V. Keith Hughitt, Carlos A. Velikovsky, Roy A. Mariuzza, Najib M. El-Sayed, Volker Briken
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT The cell wall of Mycobacterium tuberculosis is composed of unique lipids that are important for pathogenesis. Indeed, the first-ever genetic screen in M. tuberculosis identified genes involved in the biosynthesis and transport of the cell wa
Externí odkaz:
https://doaj.org/article/0e3bad085cc34cf9b1eece179b714cd2
Autor:
Ehud Inbar, V. Keith Hughitt, Laura A. L. Dillon, Kashinath Ghosh, Najib M. El-Sayed, David L. Sacks
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT The life cycle of the Leishmania parasite in the sand fly vector involves differentiation into several distinctive forms, each thought to represent an adaptation to specific microenvironments in the midgut of the fly. Based on transcriptome
Externí odkaz:
https://doaj.org/article/0237bcd8c10b4444ae0c597be089eebf
Autor:
Beverly A. Mock, Carleen Klumpp-Thomas, Zina Itkin, David S. Schrump, Kelli M. Wilson, Xiaohu Zhang, Yan-Jin Liu, Crystal McKnight, V. Keith Hughitt, Michele Ceribelli, Lu Chen, Anju Kumari, Haobin Chen, Craig J. Thomas, Lisa Gesumaria
PurposeSCLC is a recalcitrant malignancy with limited treatment options. BET inhibitors have shown promising preclinical activity in SCLC, but their broad sensitivity spectrum limits their clinical prospects in this malignancy. Drug combination could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39955ab13c6d2969781fa0f1e62d6b5d
https://doi.org/10.1101/2021.11.08.467833
https://doi.org/10.1101/2021.11.08.467833
Autor:
Sayeh Gorjifard, Beverly A. Mock, Snehal M. Gaikwad, Shuling Zhang, V Keith Hughitt, Wendy Dubois, Ke Zhang, Tyler J Peat, John K. Simmons
Publikováno v:
Journal of cancer metastasis and treatment
Long-term genetic studies utilizing backcross and congenic strain analyses coupled with positional cloning strategies and functional studies identified Cdkn2a, Mtor, and Mndal as mouse plasmacytoma susceptibility/resistance genes. Tumor incidence dat
Autor:
David M. Mosser, Najib M. El-Sayed, Stephen M. Christensen, Jingya Wang, Prabha Chandrasekaran, Elizabeth Dalby, Ronald Herbst, Wagner Luiz Tafuri, Kajal Hamidzadeh, Rosa Maria Esteves Arantes, Ismael Alves Rodrigues, V. Keith Hughitt, Gary P. Sims
Publikováno v:
J Immunol
To maintain homeostasis, macrophages must be capable of assuming either an inflammatory or an anti-inflammatory phenotype. To better understand the latter, we stimulated human macrophages in vitro with TLR ligands in the presence of high-density immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc68e6abbe23818320c384640a47a263
https://europepmc.org/articles/PMC9358719/
https://europepmc.org/articles/PMC9358719/
Autor:
Kolja Glogowski, W. T. Barnes, Sophie A. Murray, Stuart Mumford, James Mason, Trung Kien Dang, Sudarshan Konge, David Pérez-Suárez, Asish Panda, N. Freij, Tiago M. D. Pereira, Albert Y. Shih, Steven Christe, Jack Ireland, Shane A. Maloney, Tannmay Yadav, Prateek Chanda, Jongyeob Park, Daniel F. Ryan, Sabrina Savage, Garrison Taylor, Russell J. Hewett, Kevin Reardon, Andrew Inglis, Andrew Hill, Laura A. Hayes, Yash Jain, V. Keith Hughitt, Michael S. Kirk, Monica G. Bobra, Kaustubh Hiware, David Stansby, Brigitta Sipocz, Rajul
The goal of the SunPy project is to facilitate and promote the use and development of community-led, free, and open source data analysis software for solar physics based on the scientific Python environment. The project achieves this goal by developi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed8c3177eafd79d1d8bf09ea464711c
http://hdl.handle.net/10852/82978
http://hdl.handle.net/10852/82978