Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy

Autor: Dick Lindhout, V K Hiilesmaa, S Koch, H. Meinardi, C M van Duijn, A. Hofman, A H Bardy, E. B. Samren, H. Klepel, Eija Gaily, G B Mannagetta, D. Janz, D. E. Grobbee, Marja-Liisa Granström, A W Deichl

Publikováno v: Epilepsia, 38, 981-990
Epilepsia, 38(9), 981-990. Wiley-Blackwell Publishing Ltd
Epilepsia, 38, 9, pp. 981-990
Epilepsia, 38, pp. 981-990

Summary: Purpose: To quantify the risks of intrauterine antiepileptic drug (AED) exposure in monotherapy and poly-therapy. Methods: Data from five prospective European studies totaling 1,379 children were pooled and reanalyzed. Data were available fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c74510301b8c3a00331e7c374e5770c
http://hdl.handle.net/2066/24373

Pregnancy and birth in women with epilepsy

Autor: V K, Hiilesmaa

Publikováno v: Neurology. 42(4 Suppl 5)

The literature pertinent to obstetric aspects of the pregnancies in women with epilepsy is reviewed. The small risk (1%) of malformations of fetal central nervous system attributed to the use of carbamazepine or valproate during pregnancy should not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea5694dc37238b5466de48bd18cd1b0c
https://pubmed.ncbi.nlm.nih.gov/1574182

Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome

Autor: Kari Teramo, M L Granström, V K Hiilesmaa, A H Bardy

Serum folate concentrations, blood counts, and antiepileptic drug concentrations were measured during 133 pregnancies of 125 women with epilepsy. There was an inverse correlation between serum folate concentrations and concentrations of phenytoin and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478f5dafa8aec29c8f3d102c95996cba
https://europepmc.org/articles/PMC1549018/

Evaluation of placental function in women on antiepileptic drugs

Autor: V. K. Hiilesmaa

Placental function in the presence of antiepileptic drugs was assessed in 144 unselected late pregnancies of women with epilepsy. The most common drugs of the mothers were phenytoin (104 pregnancies), carbamazepine (42) and phenobarbitone (26). 144 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7907e7c940b19f61246aa48637fa78
http://edoc.hu-berlin.de/18452/12130