Zobrazeno 1 - 10
of 46
pro vyhledávání: '"V J, Lotti"'
Autor:
W T, Ashton, S M, Hutchins, W J, Greenlee, G A, Doss, R S, Chang, V J, Lotti, K A, Faust, T B, Chen, G J, Zingaro, S D, Kivlighn
Publikováno v:
Journal of Medicinal Chemistry. 36:3595-3605
Two series of potential angiotensin II antagonists derived from carboxyl-functionalized "diazole" heterocycles have been prepared and evaluated. Initially, a limited investigation of 4-arylimidazole-5-carboxylates led to 2-n-butyl-4-(2-chlorophenyl)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753bfdfbaa35b0d4d38b18fe302a41b2
https://doi.org/10.1021/jm00075a014
https://doi.org/10.1021/jm00075a014
Autor:
S. D. Kivlighn, W. R. Huckle, G. J. Zingaro, R. A. Rivero, V. J. Lotti, R. S. Chang, T. W. Schorn, N. Kevin, R. G. Johnson, W. J. Greenlee, al. et
Publikováno v:
The American journal of physiology. 268(3 Pt 2)
L-162,313 (5,7-dimethyl-2-ethyl-3-[[4-[2(n- butyloxycarbonylsulfonamido)-5-isobutyl-3-thienyl]phenyl]methyl]- imadazo[4,5-b]pyridine) is a nonpeptide that mimics the biological actions of angiotensin II (ANG II). The intravenous administration of L-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea11ce1910b36d980834ad4c9dba0575
https://pubmed.ncbi.nlm.nih.gov/7900925
https://pubmed.ncbi.nlm.nih.gov/7900925
Autor:
P K, Chakravarty, E M, Naylor, A, Chen, R S, Chang, T B, Chen, K A, Faust, V J, Lotti, S D, Kivlighn, R A, Gable, G J, Zingaro
Publikováno v:
Journal of medicinal chemistry. 37(24)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08942b48fd2d617b8b366aac662c7c6
https://pubmed.ncbi.nlm.nih.gov/7990105
https://pubmed.ncbi.nlm.nih.gov/7990105
Publikováno v:
Molecular pharmacology. 42(6)
[3H]L-158,809, a new potent and AT1-selective nonpeptide angiotensin II receptor antagonist, bound saturably and reversibly to rat adrenal membranes. Scatchard and Hill plot analyses indicated a single class of high affinity (Kd = 0.66 nM) binding si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d970b2c3832738c07125a2e925aa59f0
https://pubmed.ncbi.nlm.nih.gov/1480133
https://pubmed.ncbi.nlm.nih.gov/1480133
Publikováno v:
American journal of hypertension. 5(9)
Angiotensin II (AII) can release arachidonic acid metabolites such as prostacyclin (PGI2) and PGE2 from cells in cultures. It has recently been reported that the AT1 selective nonpeptide AII receptor antagonist losartan had similar effects. The prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfc8e4f51f3e80b2d2067c96096300c6
https://pubmed.ncbi.nlm.nih.gov/1418854
https://pubmed.ncbi.nlm.nih.gov/1418854
Autor:
P K, Siegl, R S, Chang, N B, Mantlo, P K, Chakravarty, D L, Ondeyka, W J, Greenlee, A A, Patchett, C S, Sweet, V J, Lotti
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(1)
L-158,809 (5,7-dimethyl-2-ethyl-3-[[2'-(1H-tetrazol-5yl)[1,1']-bi- phenyl-4-yl]-methyl]-3H-imidazo[4,5-b]pyridine) is a potent, competitive and specific antagonist of AT1 subtype of angiotensin II (AII) receptors in in vitro radioligand binding and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73245aaec5eabe7ff5180ade43207d5e
https://pubmed.ncbi.nlm.nih.gov/1625193
https://pubmed.ncbi.nlm.nih.gov/1625193
Autor:
R S, Chang, P K, Siegl, B V, Clineschmidt, N B, Mantlo, P K, Chakravarty, W J, Greenlee, A A, Patchett, V J, Lotti
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(1)
L-158,809 interacted in a competitive manner with rabbit aortic angiotensin II (AII) receptors as determined by Scatchard analysis of the specific binding of [125I]Sar1Ile8-AII. The affinity of L-158,809 (IC50 = 0.3 nM) for AII receptors in this tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2214b8ef1810edd3bbc79f230d7f2839
https://pubmed.ncbi.nlm.nih.gov/1625192
https://pubmed.ncbi.nlm.nih.gov/1625192
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 261(3)
Angiotensin II (AII) elicits a positive inotropic response in cardiac muscle preparations from several species including humans. The purpose of this study was to characterize the AII binding sites and inotropic responses in rabbit ventricle using the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10aa033b12079f5fdef71464b344d64c
https://pubmed.ncbi.nlm.nih.gov/1602398
https://pubmed.ncbi.nlm.nih.gov/1602398
Autor:
R S, Chang, V J, Lotti
Publikováno v:
Molecular pharmacology. 37(3)
The nonpeptide angiotensin II antagonists Dup-89 and WL-19 displaced specific 125I-angiotensin II binding in rat whole adrenal in a clearly biphasic manner, indicating the presence of high (nanomolar) and low (micromolar) affinity sites, each represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0737f12841c20a3a9cbb9f4985689440
https://pubmed.ncbi.nlm.nih.gov/2314387
https://pubmed.ncbi.nlm.nih.gov/2314387
Autor:
W. S. Saari, S. W. King, V. J. Lotti, Hunt Cecilia, D. A. Taylor, J. P. Guare, W. C. Randall, Wasyl Halczenko, Huff, P. S. Anderson
Publikováno v:
Journal of Medicinal Chemistry. 26:1696-1701
A series of 1-(2-pyridinyl)piperazine derivatives was synthesized and evaluated for adrenergic activity. In vitro activity was assessed through the antagonism of clonidine's effect in the rat, isolated, field-stimulated vas deferens and by the displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca44f469da71289daed502b6c85ae93
https://doi.org/10.1021/jm00366a007
https://doi.org/10.1021/jm00366a007