Výsledky vyhledávání - "V I, Avramis"

Pharmacology of cytarabine given as a continuous infusion followed by mitoxantrone with and without amsacrine/etoposide as reinduction chemotherapy for relapsed or refractory pediatric acute myeloid leukemia

Autor: Jorge A. Ortega, S Carcich, V I Avramis, M F Ozkaynak

Publikováno v: Medical and Pediatric Oncology. 31:475-482

Background The outcome of patients with acute myeloid leukemia (AML) who relapse or fail to achieve an initial remission has been dismal. Procedure Fifteen pediatric patients with AML, 4 relapsed and 11 primary refractory, were reinduced with a loadi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2895dd95ba8e23c0cd5a82e03c88b69
https://doi.org/10.1002/(sici)1096-911x(199812)31:6<475::aid-mpo3>3.0.co

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Comparison of intramuscular therapy with Erwinia asparaginase and asparaginase Medac: pharmacokinetics, pharmacodynamics, formation of antibodies and influence on the coagulation system

Autor: B K, Albertsen, H, Schrøder, J, Ingerslev, P, Jakobsen, V I, Avramis, H J, Müller, N T, Carlsen, K, Schmiegelow

Publikováno v: British journal of haematology. 115(4)

Asparaginase comes from different biological sources and the various preparations have different pharmacokinetic properties, and their tendency to induce side-effects is different. Erwinia asparaginase (ASNase) has a shorter half-life than the Escher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c61f8330ebfbe95a2c5fca02fcea27bf
https://pubmed.ncbi.nlm.nih.gov/11843837

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Taxotere and vincristine inhibit the secretion of the angiogenesis inducing vascular endothelial growth factor (VEGF) by wild-type and drug-resistant human leukemia T-cell lines

Autor: I A, Avramis, R, Kwock, V I, Avramis

Publikováno v: Anticancer research. 21(4A)

Recent studies have shown that angiogenesis, which is induced by VEGF, may be involved in the pathogenesis of hematopoietic malignancies. A human leukemia model consisting of T-lymphoblastic CEM/0, 7 monoclonal refractory clones resistant to both cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0adfd8cb3306412943145f5ad7ea3fa0
https://pubmed.ncbi.nlm.nih.gov/11724283

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Development of a double-drug-resistant human leukemia model to cytosine arabinoside and L-asparaginase: evaluation of cross-resistance to other treatment modalities

Autor: F, Majlessipour, R, Kwock, S, Martin-Aragon, K I, Weinberg, V I, Avramis

Publikováno v: Anticancer research. 21(1A)

We have developed an in vitro model of 38 T-lymphoblastic leukemia lines resistant to cytosine arabinoside (ara-C) and L-asparaginase (ASNase). Of these, 26 cell lines resistant to both drugs, 6 resistant to ara-C, and 6 resistant to ASNase were isol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a04c3947bb25698874bbd7d644e8894f
https://pubmed.ncbi.nlm.nih.gov/11299723

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Synergistic antiviral effect of PEG-asparaginase (ONCASPAR), with protease inhibitor alone and in combination with RT inhibitors against HIV-1 infected T-cells: a model of HIV-1-induced T-cell lymphoma

Autor: V I, Avramis, R, Kwock, I A, Avramis, L J, Cohen, C, Inderlied

Publikováno v: In vivo (Athens, Greece). 15(1)

We evaluated the anti-HIV-1 activity of the T-cell-specific protein inhibitor PEG-asparaginase (PEG-ASNase) in human HIV-1-infected T-cells. We further examined the drug synergism between PEG-ASNase and the protease inhibitor Saquinavir (SAQ), both a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c190dc4a460040cc361cd21fb4392fe
https://pubmed.ncbi.nlm.nih.gov/11286117

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Cytosine arabinoside (ara-C) resistance confers cross-resistance or collateral sensitivity to other classes of anti-leukemic drugs

Autor: S, Martin-Aragon, S K, Mukherjee, B J, Taylor, S P, Ivy, C H, Fu, V C, Ardi, V I, Avramis

Publikováno v: Anticancer research. 20(1A)

The major limitation of treatment with antimetabolite drugs is that they produce resistant clones both in vitro and in patients who either do not respond to treatment or relapse soon after response has been documented. To better understand the phenom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7730e22bf1f86f1ae017cda2dac926f3
https://pubmed.ncbi.nlm.nih.gov/10769646

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Inhibition of ribonucleotide reductase by a new class of isoindole derivatives: drug synergism with cytarabine (Ara-C) and induction of cellular apoptosis

Autor: P, Nandy, E J, Lien, V I, Avramis

Publikováno v: Anticancer research. 19(3A)

The hydroxyisoindole dione derivatives ISID and MISID are new compounds with structures resembling purines and possessing a hydroxamic acid moiety which is the pharmacophore of hydroxyurea (HU), an inhibitor of ribonucleotide reductase (RR). ISID and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::943faac6028115931f50106410790ac6
https://pubmed.ncbi.nlm.nih.gov/10470093

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Autor: M F, Ozkaynak, V I, Avramis, S, Carcich, J A, Ortega

Publikováno v: Medical and pediatric oncology. 31(6)

The outcome of patients with acute myeloid leukemia (AML) who relapse or fail to achieve an initial remission has been dismal.Fifteen pediatric patients with AML, 4 relapsed and 11 primary refractory, were reinduced with a loading bolus of 0.5 g/m2 c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::979ef4bb253087a5d0542f2ac5e30dda
https://pubmed.ncbi.nlm.nih.gov/9835899

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Increased p21/WAF-1 and p53 protein levels following sequential three drug combination regimen of fludarabine, cytarabine and docetaxel induces apoptosis in human leukemia cells

Autor: V I, Avramis, P, Nandy, R, Kwock, M M, Solorzano, S K, Mukherjee, P, Danenberg, L J, Cohen

Publikováno v: Anticancer research. 18(4A)

Combinations of nucleoside analog drugs, such as F-araA and ara-C, combined with Topoisomerase II inhibitors, such as anthracyclines, are synergistic against human leukemic T-cells and induce apoptotic cell death. Similarly, nucleoside analog drugs f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a479a5a3dfdd37e435357103f403145
https://pubmed.ncbi.nlm.nih.gov/9703875

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