Výsledky vyhledávání - "V H, Engelhard"

Perforin-dependent cytotoxic activity and lymphokine secretion by CD4+ T cells are regulated by CD8+ T cells

Autor: N S Williams, V H Engelhard

Publikováno v: The Journal of Immunology. 159:2091-2099

Factors influencing the development of CD4+ T cell subpopulations with differing lymphokine profiles are well established. However, CD4+ cells can show both perforin- and Fas ligand-dependent cytotoxicity, and little is known about conditions favorin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43e27bf78de9a34538537109a3bb3596
https://doi.org/10.4049/jimmunol.159.5.2091

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A naturally processed peptide presented by HLA-A*0201 is expressed at low abundance and recognized by an alloreactive CD8+ cytotoxic T cell with apparent high affinity

Autor: W Wang, P H Gulden, R A Pierce, J Shabanowitz, S T Man, D F Hunt, V H Engelhard, J A Shabanowitz

Publikováno v: The Journal of Immunology. 158:5797-5804

In contrast to T cells that respond to peptides presented by self MHC molecules, alloreactive T cells recognize determinants expressed on nonself MHC molecules. Because current positive selection models suggest that T cell affinity toward a nonself M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0103966ac7f7b560cfd6b1b18286984b
https://doi.org/10.4049/jimmunol.158.12.5797

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Differential contact of disparate class I/peptide complexes as the basis for epitope cross-recognition by a single T cell receptor

Autor: D J Loftus, Y Chen, D G Covell, V H Engelhard, E Appella

Publikováno v: The Journal of Immunology. 158:3651-3658

In an effort to better understand functional recognition of structurally dissimilar ligands by a single TCR, a model system for studying cross-recognition of disparate peptide/class I complexes was developed using the murine (H-2b) CTL clone AHIII12.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35f7020c283b3f158a676885eee45c4b
https://doi.org/10.4049/jimmunol.158.8.3651

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Probing HLA-B7 conformational shifts induced by peptide-binding groove mutations and bound peptide with anti-HLA monoclonal antibodies

Autor: K D Smith, B E Mace, A Valenzuela, J L Vigna, J A McCutcheon, J A Barbosa, E Huczko, V H Engelhard, C T Lutz

Publikováno v: The Journal of Immunology. 157:2470-2478

To determine the influence of peptide-binding groove residues and MHC-bound peptide on HLA-B7 conformation, we investigated the binding sites of nine locus- or allele-specific mAbs using a panel of 82 HLA-B7 variants. The functional mAb epitopes enci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d4a8448ade1168a87414e9594edcb59
https://doi.org/10.4049/jimmunol.157.6.2470

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Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules

Autor: M H Newberg, D H Smith, S B Haertel, D R Vining, E Lacy, V H Engelhard

Publikováno v: The Journal of Immunology. 156:2473-2480

The importance of the species of different domains of class I MHC molecules in peripheral T cell recognition and positive and negative selection was evaluated in a single system. In transgenic mice expressing AAD (containing the alpha1+alpha2 domains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0cf572b09ef7f7702041718b8d63004
https://doi.org/10.4049/jimmunol.156.7.2473

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Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism

Autor: N S Williams, V H Engelhard

Publikováno v: The Journal of Immunology. 156:153-159

Although cytotoxic activity has generally been shown to reside in the CD8+ population of T lymphocytes, there are numerous examples of cytotoxic CD4+ T cells. In the present study, we found that after depletion of CD8+ T cells, CD4+ T cells cultured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e12baa73c7abab8210008e7b2dd11f4b
https://doi.org/10.4049/jimmunol.156.1.153

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Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules

Autor: D M Smith, J A Bluestone, D R Jeyarajah, M H Newberg, V H Engelhard, J R Thistlethwaite, E S Woodle

Publikováno v: The Journal of Immunology. 153:1054-1067

A long term goal of investigators working in our laboratory has been to develop new mAbs for use as immunosuppressive agents. As a means toward achieving this goal, several new mAbs (hybridomas) have been developed by screening fusions for supernatan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4754cd62c475f20b616cfb0462c16325
https://doi.org/10.4049/jimmunol.153.3.1054

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Species specificity in the interaction of CD8 with the alpha 3 domain of MHC class I molecules

Autor: M H Newberg, J P Ridge, D R Vining, R D Salter, V H Engelhard

Publikováno v: The Journal of Immunology. 149:136-142

The alpha 1 and alpha 2 domains of the class I MHC molecule constitute the putative binding site for processed peptides and the TCR, although the alpha 3 domain has been implicated as a binding site for the CD8 molecule. Species specificity in the bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23809bd82ccc51c81c549b773fb0d882
https://doi.org/10.4049/jimmunol.149.1.136

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Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2

Autor: D B Crumpacker, J Alexander, P Cresswell, V H Engelhard

Publikováno v: The Journal of Immunology. 148:3004-3011

One model to explain the high frequency of alloreactive T cells proposes that allogeneic MHC molecules are recognized together with host cell-derived peptides. A model system was developed to investigate the relevance of this mechanism by expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8975b37bcc18a606de689ff37ec10b10
https://doi.org/10.4049/jimmunol.148.10.3004

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Three intracellular signals for cytotoxic T lymphocyte-mediated killing. Independent roles for protein kinase C, Ca2+ influx, and Ca2+ release from internal stores

Autor: D M Haverstick, V H Engelhard, L S Gray

Publikováno v: The Journal of Immunology. 146:3306-3313

Ligation of the TCR after interaction of a CTL with a relevant target cell results in a change in CTL shape with reorientation and secretion of cytoplasmic granules. Secretion can be induced by treating CTL with the combination of a phorbol ester to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38550dfc35a3e965551d422b5a028cf8
https://doi.org/10.4049/jimmunol.146.10.3306

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