Zobrazeno 1 - 10
of 178
pro vyhledávání: '"V Griffith"'
Autor:
Min Zhao, Sarah M. Kurtis, Ellen A. Humbel, Emily V. Griffith, Tong Liu, Edward L. Braun, Richard Buchholz, Rebecca T. Kimball
Publikováno v:
Royal Society Open Science, Vol 11, Iss 1 (2024)
A morphological trait can have multiple functions shaped by varying selective forces. Bare parts in birds, such as wattles, casques and combs, are known to function in both signalling and thermoregulation. Studies have demonstrated such structures ar
Externí odkaz:
https://doaj.org/article/e1acf3c298154596a7e34a46d4878286
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
One aspect of ageing on immunity is attributed to accelerated thymic atrophy, but the underlying mechanism is still lacking. Here the authors show, using conditional reporter mouse models, that both atrophy and regeneration of the thymus are regulate
Externí odkaz:
https://doaj.org/article/df914271f29b44e993752f1172f879f4
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The thymus is the primary site of T lymphocyte development, where mutually inductive signaling between lymphoid progenitors and thymic stromal cells directs the progenitors along a well-characterized program of differentiation. Although thymic stroma
Externí odkaz:
https://doaj.org/article/6a29a05d8dcf474591b384cd41bb47b9
Autor:
Sergio Cepeda, Carolina Cantu, Stephanie Orozco, Yangming Xiao, Zoe Brown, Manpreet K. Semwal, Thomas Venables, Mark S. Anderson, Ann V. Griffith
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1276-1287 (2018)
Summary: Although autoimmune disorders are a significant source of morbidity and mortality in older individuals, the mechanisms governing age-associated increases in susceptibility remain incompletely understood. Central T cell tolerance is mediated
Externí odkaz:
https://doaj.org/article/2fc1001756ed417bbfa034df07a3b141
Publikováno v:
The Journal of Immunology. 209:950-959
The thymus is a primary lymphoid organ for T cell development. Increasing evidence found that the thymus is also an important site for development of innate lymphoid cells (ILCs). ILCs generated in thymi acquire unique homing properties that direct t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::445efaec613982e3408fcf0d2428a4d3
https://doi.org/10.4049/jimmunol.2100870
https://doi.org/10.4049/jimmunol.2100870
Akademický článek
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Akademický článek
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Autor:
Manpreet K. Semwal, Allison K. Hester, Yangming Xiao, Chioma Udeaja, Sergio Cepeda, John S. Verschelde, Nicholas Jones, Sarah A. Wedemeyer, Simon Emtage, Kymberly Wimberly, Ann V. Griffith
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
Thymic stromal cells (TSCs) are critical regulators of T cell tolerance, but their basic biology has remained under-characterized because they are relatively rare and difficult to isolate. Recent work has revealed that constitutive autophagy in TSCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff3bb34cdfd01f9c959592a68421b23
https://pubmed.ncbi.nlm.nih.gov/36161925
https://pubmed.ncbi.nlm.nih.gov/36161925
Autor:
Ann V. Griffith, Thomas Venables, Jianjun Shi, Andrew Farr, Holly van Remmen, Luke Szweda, Mohammad Fallahi, Peter Rabinovitch, Howard T. Petrie
Publikováno v:
Cell Reports, Vol 12, Iss 7, Pp 1071-1079 (2015)
T lymphocytes are essential mediators of immunity that are produced by the thymus in proportion to its size. The thymus atrophies rapidly with age, resulting in progressive diminution of new T cell production. This decreased output is compensated by
Externí odkaz:
https://doaj.org/article/dfea9ee59cf5442fba068048f8e21d91
Autor:
A Whelan, R Murphy, E Shiel, V Griffith, K Mannion, M Ní Neachtain, E Mannion, M Conry, J Geoghegan, R Waters, M O'Donnell, S Robinson, M Canavan
Publikováno v:
Age and Ageing. 51
Background Home support services aim to support older people to remain at home. Despite substantial investment in home support hours (€600 million), this has not translated into increased carers on the ground for older people. We aimed to report pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a5f7bee9f3ffece45f94659540754a8
https://doi.org/10.1093/ageing/afac218.312
https://doi.org/10.1093/ageing/afac218.312